Guardians vs. Astros Odds & Betting Predictions - June 21, 2026

Guardians at Astros

6:10 pm • CLEG

Cleveland Guardians

@

Houston Astros

pitcher		team	era	w-l
K.Teng			0.00	0-0
S.Cecconi			0.00	0-0

MatchupOpenSpreadTotalMoneyline
Guardians 39-35	N/A	N/A	N/A
Astros 35-41	N/A	N/A	N/A

location pin

Sunday 6:10 p.m.

June 21, 2026

Daikin ParkHouston

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90°Fahrenheit

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0%Rain

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12Wind

No props found

MLB Public Betting

Astros are 3-2 in their last 5 games.
Astros are 3-2 in their last 5 games against the spread
Astros are 18-20 in their road games against the spread
The totals have gone OVER in 2 of Astros' last 5 games
The totals have gone OVER in 22 of Astros' 38 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Astros	36-40	18-20	18-20	7-16	28-23
Guardians	39-35	19-17	20-18	18-23	21-12

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Astros	39-33-4	22-15-1	17-18-3	13-10	25-22-4
Guardians	36-38	18-18	18-20	21-20	15-18

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Astros	35-41	18-20	17-21	9-14	25-26
Guardians	39-35	19-17	20-18	22-19	17-16

date	opponent	score	spread	over/under	moneyline
Jun 17th	DET	W 4-2	+1.5 W	U 8.5	HOU -110
Jun 17th	DET	W 4-2	-1.5 W	U 8.5	HOU -175
Jun 16th	DET	L 3-9	-1.5 L	O 9	DET -125
Jun 14th	@KC	L 0-4	-1.5 L	U 8.5	KC -101
Jun 13th	@KC	W 8-7	+1.5 W	O 9.5	HOU +113

Lance McCullers
SP
Lance McCullers Jr. has been scratched Tuesday. Jason Alexander will start.
Out

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MatchupOverUnder
Guardians 39-35	N/A	N/A
Astros 35-41	N/A	N/A