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Padres vs. Mariners Odds & Betting Predictions - May 16, 2026

Padres at Mariners

1:40 am • SEAM

San Diego Padres

25-18
@

Seattle Mariners

22-23
Starting Pitchers
pitcherteameraw-l
Emerson Hancock logoE.HancockSeattle Mariners logo3.213-1
Randy Vasquez logoR.VasquezSan Diego Padres logo3.054-1

Padres at Mariners Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Padres
25-18
+1.5
+1.5-187
o7-116
+115
Mariners
22-23
u7.5
-1.5+155
u7-107
-139
location pinSaturday 1:40 a.m.
May 16, 2026
T-Mobile ParkSeattle
thermometer image53°Fahrenheit
rain image50%Rain
wind image12Wind
Padres vs. Mariners Expert Picks
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 262-357-20 (-6.1u)
E.Hancock o5.5 Ks+144
0.81u
#EV
Frank Ammirante
Frank Ammirante
Last 30d: 289-286-6 (+12.8u)
E.Hancock o4.5 Ks-155
1.55u
Sean Zerillo
Sean Zerillo
Last 30d: 161-158-14 (-4.7u)
Under 7.5-112
0.56u
Bet to 7 (-105)

Prop Odds Comparison

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No props found

Line Movement Tracker

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Padres vs. Mariners Public Betting Percentages

Away Logo

Padres

Public

Home Logo

Mariners

35%

Bets%

65%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Mariners are 3-2 in their last 5 games.
  • Mariners are 3-2 in their last 5 games against the spread
  • Mariners are 8-14 in their road games against the spread
  • The totals have gone OVER in 2 of Mariners' last 5 games
  • The totals have gone OVER in 11 of Mariners' 23 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Mariners		17-289-148-1416-261-2
Padres		23-2013-1010-1013-1210-8

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Mariners		19-24-211-11-18-13-119-21-20-3
Padres		18-24-110-12-18-129-15-19-9

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Mariners		22-2312-1110-1221-211-2
Padres		25-1813-1012-815-1010-8

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
May 14th@HOUW 8-3-1.5 WO 9SEA -115
May 14th@HOUL 3-4-1.5 LU 9HOU -136
May 13th@HOUW 10-2-1.5 WO 9SEA -202
May 12th@HOUW 3-1-1.5 WU 8.5SEA -155
May 10th@CWSL 1-2-1.5 LU 8CWS -138

Mariners vs. Padres Injury Updates

Mariners Injuries

  • Miles Mastrobuoni
    3B

    Mastrobuoni is out with calf

    Out

  • Bryce Miller
    SP

    Miller is out with oblique

    Out

Padres Injuries

  • Joe Musgrove
    SP

    Musgrove is out with elbow

    Out

  • Will Wagner
    3B

    Wagner is out with oblique

    Out

See more MLB Injuries Right Arrow
Padres vs. Mariners Starting Lineups
Padres Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Randy Vasquez logoRR.Vasquez, P4-13.041.1738.53
HITTERSAVGOBPSLGHR
Jackson Merrill logo1J.Merrill, CF.215.287.3424
Fernando Tatis logo2F.Tatis, 2B.244.318.2880
Manny Machado logo3M.Machado, 3B.190.287.3406
Miguel Andujar logo4M.Andujar, DH.289.314.4823
Xander Bogaerts logo5X.Bogaerts, SS.257.331.4147
Gavin Sheets logo6G.Sheets, 1B.229.289.4586
Nick Castellanos logo7N.Castellanos, RF.200.233.3292
Ramon Laureano logo8R.Laureano, LF.214.296.3795
Freddy Fermin logo9F.Fermin, C.176.267.2300
Mariners Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Emerson Hancock logoRE.Hancock, P3-13.211.0079.44
HITTERSAVGOBPSLGHR
Brendan Donovan logo1B.Donovan, 3B.278.396.4683
Julio Rodriguez logo2J.Rodriguez, CF.261.325.4287
Josh Naylor logo3J.Naylor, 1B.247.311.3675
Randy Arozarena logo4R.Arozarena, LF.301.389.4544
Luke Raley logo5L.Raley, RF.268.333.58910
J.P. Crawford logo6J.Crawford, SS.215.363.3625
Dominic Canzone logo7D.Canzone, DH.253.320.4624
Mitch Garver logo8M.Garver, C.176.354.2551
Cole Young logo9C.Young, 2B.248.328.3633

Padres vs. Mariners Odds Comparison

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Padres at Mariners Team Totals

MatchupOverUnder
Padres
25-18
N/A
N/A
Mariners
22-23
N/A
N/A