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Illinois vs. Penn Odds, Opening Spread, Predictions for 2026 NCAA Tournament

Illinois vs. Penn Odds, Opening Spread, Predictions for 2026 NCAA Tournament article feature image
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Tommy Gilligan-Imagn Images. Pictured: Keaton Wagler.

Illinois vs. Penn Odds

Penn Logo
Thursday, Mar 19
12 p.m. ET
Illinois Logo
Penn Odds
SpreadTotalMoneyline
+22.5
-115
149.5
-110o / -110u
+1600
Illinois Odds
SpreadTotalMoneyline
-22.5
-105
149.5
-110o / -110u
-4500
Odds via FanDuel. Get up-to-the-minute NCAAB odds here.
FanDuel Logo

The 2026 NCAA Tournament field has been announced and Illinois will take on Penn in Round 1 of the South region. Here's everything you need to know about Illinois vs. Penn odds, spread and more.

Illinois opened as a 22.5-point favorite over Penn in the first round of the NCAA Tournament. The total is set at over/under 149.5 points scored by both teams combined.

Find out how No. 3-seeded Illinois and No. 14-seeded Penn match up ahead of their opening round matchup.


Illinois vs. Penn Analysis

Penn upset Yale in eye-popping fashion in the Ivy League final. Former Duke and Virginia big man TJ Power dropped 44 points, including the game-tying 3 in the final seconds to send the game to overtime.

It was a fairly shocking upset, given that Penn was missing leading scorer Ethan Roberts due to a concussion and Yale was favored by 9.5 points.

This is a Penn team that started Ivy League play 2-4 but has now lost just once since Jan. 30.

The Quakers will face the gigantic Illinois frontline that hammers teams on the offensive glass. Penn’s bigs will face major challenges in the paint and trying to score over the Ivisic brothers inside.

Illinois has been sharp against lesser competition, winning all 18 of its games against teams outside KenPom’s top-30 teams. The Illini went 8-2 against the spread when favored by more than 15 points.


For more coverage of the 2026 NCAA Tournament and Selection Sunday, make sure to check out our experts' live reactions to the bracket reveal and the Selection Sunday live show, where you can get their instant analysis on every matchup as well as some early insights to help you make your bets.

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