The Missouri Tigers take on the Notre Dame Fighting Irish in South Bend, IN. Tip-off is set for 9 p.m. ET on ESPNU.
Notre Dame is favored by -1.5 points on the spread with a moneyline of -110. The total is set at 151.5 points.
Here’s my Missouri vs. Notre Dame prediction and college basketball picks for December 2, 2025.
Missouri vs Notre Dame Prediction
My Pick: Under 151.5 (Play to 147)
My Missouri vs Notre Dame best bet is on the under. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
Missouri vs. Notre Dame Odds
| Missouri Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -120 | 151.5 -110o / -110u | -110 |
| Notre Dame Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +100 | 151.5 -110o / -110u | -110 |
- Missouri vs Notre Dame spread: Notre Dame -1.5
- Missouri vs Notre Dame over/under: 151.5 points
- Missouri vs Notre Dame moneyline: Missouri -110, Notre Dame -110
Missouri vs Notre Dame College Basketball Betting Preview
Missouri Basketball
Dennis Gates is on a mission to prove that Missouri is here to stay as a regular in the NCAA Tournament. This season, the Tigers are 30th in KenPom, are 8-0 and have seven wins by double-digits.
As was the case last season, Missouri is one of the 20-most efficient offenses in America. The Tigers have overwhelmed opponents with their driving ability and offensive rebounding. They rank fourth nationally with a 64.9% 2-point percentage. Plus, they grab 42.7% of their misses.
Missouri used its size and athleticism to overwhelm smaller mid-major opponents. It'll be tougher to overwhelm teams with similar size, though, so the Tigers will have to shoot it better from deep.
Their leading scorer — Mark Mitchell — is strong as an ox and tough to stop inside. He's a total non-threat from deep, though. The same applies to uber-athletic seven-footer Shawn Phillips Jr. and burly guard Sebastian Mack.
The Tigers hit 39% from deep, but I'm not fully buying it. One of their top shooters is Jayden Stone, who's out for the next month with a hand injury. Point guard Anthony Robinson II is drilling 44% from 3 this year, which is a major boost compared to where he was last year.
On the defensive end, I think Missouri is better than its 73rd-ranked defensive efficiency says. Opponents hit just 43.7% versus Missouri from 2-point range, along with posting a 19% turnover rate.
From a tempo standpoint, Missouri is about middle of the pack nationally at 162nd. It'll look to push the pace more than Notre Dame, but it won't be anything too fast.
Notre Dame Basketball
Notre Dame spent last week in Vegas playing in the Players Era Festival, where it went 1-2, with the lone win coming over Rutgers. The Fighting Irish are now 5-3 with all three of their losses coming to top-35 teams in KenPom (Ohio State, Kansas and Houston).
The Fighting Irish tend to have lower-scoring games, and that continued in Vegas. They scored fewer than 70 points in all three games, and each affair finished with 132 or fewer combined points.
I'd expect a lot of lower-scoring games from Notre Dame this season, as it sits 317th in adjusted tempo.
The Fighting Irish rank 66th in defensive efficiency, and that's a major improvement from 2024-25. The biggest difference is that Notre Dame couldn't stop anyone at the rim last season. So far in 2025-26, an improved interior has allowed the Fighting Irish to limit teams to 48% shooting from inside the arc.
Carson Towt has played an indispensable role for Notre Dame. The transfer from Northern Arizona is the perfect glue guy big man. He plays hard, grabs a ton of rebounds — 10.3 per game to be exact — which is almost double what Kebba Njie notched last season.
Notre Dame is much more shaky on the offensive end. Coming into this game, the Fighting Irish are 81st in offensive efficiency, and they rank outside the top 115 in 2-point and 3-point percentage.
Much of what happens on a night-to-night basis for Notre Dame depends on whether the hero-ball approach works for Markus Burton. And I don't say hero ball in a derogatory fashion here. Burton is very efficient for a high-volume scorer, and he's averaging 20 points per game.
Burton is one of two Notre Dame players averaging double-digits. The other is freshman Jalen Haralson. The 6-foot-7 freshman isn't a shooter, but he's a terrific driver and makes plays at the hoop.
Missouri vs. Notre Dame Betting Analysis
I'm eyeing the under in this ACC/SEC Challenge matchup.
Notre Dame has to play low-scoring games due to its lack of offensive firepower (outside of Burton) and pace.
Missouri has put up big scoring numbers, but most of them came against inferior opponents.
Facing a strong defense and a well-coached squad with size and athleticism to match, Missouri will make for a tougher test.
My Pick: Under 151.5 (Play to 147)
