Michigan State vs USC Odds & Live Scores - September 20, 2025

Michigan St at USC

3:00 am • FOX

Michigan State Spartans

2-1

31 - 45

USC Trojans

4-0

MatchupOpenSpreadTotalMoneyline
Michigan St 2-1	+14.5	+18.5-114	o55.5-110	+625
USC 4-0	u56.5	-18.5-106	u55.5-110	-950

Sunday 3:00 a.m.

September 21, 2025

Los Angeles Memorial ColiseumLos Angeles

USC -19.5-105

USC -18.5-110

1.1u

Over 55-110

0.2u

Full Preview on Action Network.

USC -18-110

USC o37.5 Team Total-115

MSU +10.5 (1H)+100

USC o36.5 Team Total-120

0.83u

@_Collin1 https://myaction.app/V2FMmqguNWb

USC -10 (1H)-110

0.91u

@Stuckey2 https://myaction.app/V2FMmqguNWb

USC o37.5 Team Total-114

Massive EPA edge to USC offense, also top 10 Quality and Finishing Drives.

MSU +17.5-102

0.98u

Under 56.5-105

0.53u

Michigan State vs. USC: Target Saturday's Total
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No props found

NCAAF Public Betting

USC are 4-0 in their last 5 games.
USC are 1-3 in their last 5 games against the spread
USC are 0-1 in their road games against the spread
The totals have gone OVER in 3 of USC' last 4 games
The totals have gone OVER in 2 of USC' 3 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
USC	1-3	1-2	0-1	1-2	N/A
Michigan St	2-1	1-1	1-0	1-1	1-0

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
USC	3-1	2-1	1-0	2-1	N/A
Michigan St	1-2	1-1	0-1	1-1	0-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
USC	4-0	N/A	N/A	3-0	N/A
Michigan St	2-1	N/A	N/A	2-0	0-1

date	opponent	score	spread	over/under	moneyline
Sep 13th	@PUR	W 33-17	-20.5 L	U 59.5	USC -1600
Sep 6th	GASO	W 59-20	-29 W	O 62.5	USC -7000
Aug 30th	MOST	W 73-13	-36.5 W	O 60	USC -9000
Dec 28th	TA&M	W 35-31	-	-	-
Nov 30th	ND	L 35-49	+7 L	O 52.5	ND +207

Michigan St

Total

USC

337

Total Yards

523

Total Plays

6.127272727272727

Yards Per Play

7.924242424242424

Michigan St

Passing

USC

225

YDS

234

13/23

Comps/Atts

20/26

9.782608695652174

YPA

3/0

TDs/INTs

3/0

2/7

Sacks/Yards

0/0

Michigan St

Rushing

USC

112

Rush Yards

289

Attempts

3.5

YPC

7.225

TDs

Michigan St

Turnovers

USC

Fumbles Lost

Interceptions

Michigan St

Efficiency

USC

2/3 66.67%

Redzone

6/6 100%

5/11 0%

3rd Down

8/12 0%

0/1 0%

4th Down

1/2 0%

Michigan St

First Downs

USC

Total

Pass

Rush

Penalty

Michigan St

Misc

USC

6/54

Penalties/Yards

9/78

Could not load odds

See more NCAAF Odds

MatchupOverUnder
Michigan St 2-1	N/A	N/A
USC 4-0	N/A	N/A

Michigan St vs. USC Odds & Betting Predictions - September 21, 2025

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Line Movement Tracker

Michigan St vs. USC Public Betting Percentages

Michigan St

Public

USC

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Michigan St vs. USC Odds Comparison

Michigan St at USC Team Totals