Spartans vs. Trojans Odds & Betting Predictions - September 21, 2025

Spartans at Trojans

3:00 am • FOX

Michigan State Spartans

4-8

31 - 45

USC Trojans

9-4

MatchupOpenSpreadTotalMoneyline
Spartans 4-8	+14.5	+18.5-114	o55.5-110	+625
Trojans 9-4	u56.5	-18.5-106	u55.5-110	-950

Sunday 3:00 a.m.

September 21, 2025

Los Angeles Memorial ColiseumLos Angeles

USC -18.5-110

$1.10

USC -19.5-105

USC -18.5-110

1.1u

Over 55-110

0.2u

Full Preview on Action Network.

USC -18-110

USC o37.5 Team Total-115

MSU +10.5 (1H)+100

USC -10 (1H)-110

$1.00

USC o36.5 Team Total-120

0.83u

@_Collin1 https://myaction.app/V2FMmqguNWb

USC -10 (1H)-110

0.91u

@Stuckey2 https://myaction.app/V2FMmqguNWb

USC o37.5 Team Total-114

Massive EPA edge to USC offense, also top 10 Quality and Finishing Drives.

MSU +17.5-102

0.98u

Under 56.5-105

0.53u

Michigan State vs. USC: Target Saturday's Total
Mike McNamara•
Sep 20, 2025 UTC
Your Week 4 NCAAF Betting Cheat Sheet
Pete Ruden•
Sep 20, 2025 UTC
College Football Week 4 Best Bets & Player Props! | Big Bets On Campus LIVE!
•
Sep 19, 2025 UTC
Auburn vs Oklahoma BEST BETS! | College Football Best Bets & Preview | BBOC
Stuckey•
Sep 19, 2025 UTC

See more NCAAF Coverage

No props found

NCAAF Public Betting

Trojans are 4-1 in their last 5 games.
Trojans are 3-2 in their last 5 games against the spread
Trojans are 1-4 in their road games against the spread
The totals have gone OVER in 3 of Trojans' last 5 games
The totals have gone OVER in 4 of Trojans' 7 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Trojans	5-7	4-3	1-4	4-6	1-1
Spartans	7-5	1-5	5-0	1-4	6-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Trojans	6-6	4-3	2-3	5-5	1-1
Spartans	7-5	3-3	3-2	3-2	4-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Trojans	9-3	N/A	N/A	9-1	0-2
Spartans	4-8	N/A	N/A	4-1	0-7

date	opponent	score	spread	over/under	moneyline
Sep 13th	@PUR	W 33-17	-20.5 L	U 59.5	USC -1600
Sep 6th	GASO	W 59-20	-29 W	O 62.5	USC -7000
Aug 30th	MOST	W 73-13	-36.5 W	O 60	USC -9000
Dec 28th	TA&M	W 35-31	-	-	-
Nov 30th	ND	L 35-49	+7 L	O 52.5	ND +207

Spartans

Total

Trojans

337

Total Yards

523

Total Plays

6.127272727272727

Yards Per Play

7.924242424242424

Spartans

Passing

Trojans

225

YDS

234

13/23

Comps/Atts

20/26

9.782608695652174

YPA

3/0

TDs/INTs

3/0

2/7

Sacks/Yards

0/0

Spartans

Rushing

Trojans

112

Rush Yards

289

Attempts

3.5

YPC

7.225

TDs

Spartans

Turnovers

Trojans

Fumbles Lost

Interceptions

Spartans

Efficiency

Trojans

2/3 66.67%

Redzone

6/6 100%

5/11 0%

3rd Down

8/12 0%

0/1 0%

4th Down

1/2 0%

Spartans

First Downs

Trojans

Total

Pass

Rush

Penalty

Spartans

Misc

Trojans

6/54

Penalties/Yards

9/78

Could not load odds

See more NCAAF Odds

MatchupOverUnder
Spartans 4-8	N/A	N/A
Trojans 9-4	N/A	N/A

Spartans vs. Trojans Odds & Betting Predictions - September 21, 2025

Spartans at Trojans

Michigan State Spartans

USC Trojans

Spartans at Trojans Odds

Spread, Total, Moneyline

Spartans vs. Trojans Previews & Analysis

Michigan State vs. USC: Target Saturday's Total

Your Week 4 NCAAF Betting Cheat Sheet

College Football Week 4 Best Bets & Player Props! | Big Bets On Campus LIVE!

Auburn vs Oklahoma BEST BETS! | College Football Best Bets & Preview | BBOC

Prop Odds Comparison

Line Movement Tracker

Spartans vs. Trojans Public Betting Percentages

Spartans

Public

Trojans

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Spartans vs. Trojans Odds Comparison

Spartans at Trojans Team Totals