The Coastal Carolina Chanticleers take on the South Alabama Jaguars in Mobile, AL. Kickoff is set for 7 p.m. ET on ESPN+.
South Alabama is favored by -14.5 points on the spread with a moneyline of -600. The total is set at 50.5 points.
Here’s my Coastal Carolina vs South Alabama predictions and college football picks for Saturday, September 20, 2025.


Coastal Car vs S. Alabama Prediction
- Coastal Carolina vs South Alabama Pick: Under 50.5
My South Alabama vs. Coastal Carolina best bet is on the under. Find the best line available on our live NCAAF odds page.
Coastal Carolina vs South Alabama Odds
Coastal Carolina Odds | ||
---|---|---|
Spread | Total | Moneyline |
+14.5 -110 | 50.5 -110o / -110u | +450 |
South Alabama Odds | ||
---|---|---|
Spread | Total | Moneyline |
-14.5 -110 | 50.5 -110o / -110u | -600 |
- Coastal Carolina vs South Alabama point spread: South Alabama -14.5
- Coastal Carolina vs South Alabama over/under: 50.5 points
- Coastal Carolina vs South Alabama moneyline: Coastal Carolina +450, South Alabama -600

Coastal Carolina vs South Alabama Pick, Betting Analysis
Coastal Carolina's offense has looked so jerky this season.
The biggest indication of this was the Chants scoring just 13 points against Charleston Southern. Any other team in the Sun Belt would've scored 40 or 50 points against the Buccaneers in this game, but the Chants were struggling to convert on third down and they couldn't even complete a forward pass.
They've already pulled the plug on the MJ Morris experience at quarterback and have instead turned to Tad Hudson.
I just don't see Coastal being able to move the ball and convert on third downs. It's not going to be able to run the ball against South Alabama, which I've been very impressed with in its performances against Tulane and Auburn.
Because the Coastal offense shouldn't be able to do much, I like the under for this game. I also like Coastal's team total, but that bet is going to correlate with the game total result.
Pick: Under 50.5