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Week 4 College Football Picks: Our Top NCAAF Favorites for Saturday, September 26

Week 4 College Football Picks: Our Top NCAAF Favorites for Saturday, September 26 article feature image
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Reuters Connect. Pictured: Louisville RB Isaac Brown (left) and Auburn QB Byrum Brown (right).

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You may be familiar with our weekly moneyline underdog article. Well, we decided a couple of years ago that we needed to show love for the other side by also sharing our two favorite college football favorites that we share weekly on the "Big Bets on Campus" podcast.

We affectionately refer to them as "overdogs," thanks to one of our beloved callers. To kick off the chalk talk this week, we're rolling with the favorites in two Power 4 matchups.

Let's dive into our Week 4 college football picks and NCAAF predictions for Louisville vs. Wake Forest and Auburn vs. Vanderbilt on Saturday, Sept. 26. And be sure to download the Action Network app for additional picks and analysis.


Week 4 College Football Picks

  • Louisville -13.5 vs. Wake Forest
  • Auburn -9.5 vs. Vanderbilt


Wake Forest vs Louisville Pick

Wake Forest Logo
Saturday, Sept. 26
12 p.m. ET
ESPN
Louisville Logo
Wake Forest Odds
SpreadTotalMoneyline
+13.5
-105
57.5
-110o / -110u
+430
Louisville Odds
SpreadTotalMoneyline
-13.5
-115
57.5
-110o / -110u
-600
Odds via FanDuel. Get up-to-the-minute NCAAF odds here.
FanDuel Logo

By Collin Wilson

I did a complete 180 on this one. Early in the week I had Wake Forest, mostly because Louisville’s secondary looked beatable with all the injuries. Then a few things changed.

First, Wake quarterback Gio Lopez has an ugly hip issue that’s lingered since Purdue and Miami.

He was listed probable last week; this week he’s questionable, and it sounds like it’s gotten worse. That’s a red flag for an offense that relies on timing and explosive plays.

Secondly, Jeff Brohm publicly said his defense can handle Lopez because he’s similar to Kevin Jennings, who they just faced when they played SMU.

That kind of confidence matters. If the head coach believes his scheme can take away what Wake does best, I’m inclined to believe him.

The law firm of Kienholz, Brown and Brown with their zone-read stuff is also a bad look for Wake. Louisville owns a Success Rate of 40% on inside zone plays. Wake, meanwhile, ranks 128th in Havoc and bottom-15 in Quality Drives allowed.

That combination is a recipe for getting worn down.

Wake’s cover against Miami was propped up by explosive passes to Carlos Hernandez in the slot and Jack Foley outside. Louisville is going to show a ton of Cover 3 looks, though, and Wake’s numbers there are ugly with a 38% Success Rate. That’s well below the national average.

The Deacs don't throw well into Cover 3, but Miami didn’t test that shade of defense.

I think Louisville is going to run wild in this one. And if Lopez can’t go, this line won't be closing at 13.5.

Pick: Louisville -13.5


Vanderbilt vs Auburn Pick

Vanderbilt Logo
Saturday, Sept. 26
4:15 p.m. ET
SEC Network
Auburn Logo
Vanderbilt Odds
SpreadTotalMoneyline
+9.5
-110
54.5
-115o / -105u
+285
Auburn Odds
SpreadTotalMoneyline
-9.5
-110
54.5
-115o / -105u
-365
Odds via FanDuel. Get up-to-the-minute NCAAF odds here.
FanDuel Logo

By Stuckey

Auburn -9 to -9.5 for me — anything under 10 is a play. I peg this closer to a 10-point game, but I’ll happily take anything cheaper than that.

Vandy’s starting a true freshman on the road in a hostile environment, and I don’t think this Commodores team is very good this year.

Auburn’s biggest worry all season has been the offensive line, as a couple of USF transfers just haven’t translated up to this level. But that unit should be able to handle Vandy’s front.

Tigers head coach Alex Golesh is someone I trust when he’s a favorite of more than a touchdown; he’s going to want a comfortable win and won’t let up.

This feels like a classic bounce-back spot for the Tigers, while Vandy could be staring at an emotional hangover. Yes, Vandy has given Auburn trouble the last couple of years, but I like Auburn here. War Eagle.

Pick: Auburn -9.5

Author Profile
About the Author

Collin is a senior writer for the Action Network, but serves in various roles behind the scenes as well. As someone who specializes in data visualization of probabilities, power ratings, and head-to-head matchups, Collin’s work within the college football space powers the Action Network’s PRO projections throughout the college football season, and has done so since the birth of the app in 2017. Collin contributes similarly to the college basketball vertical, and his passion for predictive analytics have led him to become a key force in finding betting edges in more niche markets such as professional wrestling and entertainment awards.

Author Profile
About the Author

Stuckey is a senior betting analyst at Action Network, focusing on college football, college basketball, and the NFL. He hosts The Action Network Podcast and co-hosts the Big Bets on Campus podcast with Collin Wilson and Brett McMurphy. Stuckey was Action Network’s first content hire in 2017, helping launch their award-winning app, and continues to work closely with their development team. A CFA Charterholder, Stuckey has been betting since 2003 and has a background as a derivatives analyst in the financial industry. He holds an MBA from George Washington University.

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