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College Football Picks for Saturday: 4 Smartest Week 8 Predictions, Including Minnesota vs. Penn State

College Football Picks for Saturday: 4 Smartest Week 8 Predictions, Including Minnesota vs. Penn State article feature image
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Photo by Mike Mulholland/Getty Images. Pictured: Head coach James Franklin of the Penn State Nittany Lions

  • College football picks for Week 8 on Saturday can come from any game, no matter how big or how small.
  • Interestingly, the smartest college football picks for Saturday's Week 8 slate are available from smaller games, like Toledo vs. Buffalo, as well as high-profile matchups like Minnesota vs. Penn State.
  • Continue reading to learn about the four sharpest college football picks for Saturday, Oct. 22.

Over the past few weeks, and frankly since the start of the college football season, Saturday’s smartest bets have included some of the biggest games on the slate.

However, when it comes to the latest college football odds for Week 8, the top values are coming from mid- to lower-profile games.

Sure, today’s Minnesota vs. Penn State matchup, which is lighting up all five of our College Football PRO Report’s value signals, isn’t a “small” matchup by any means, but the Nittany Lions are the only top-25 team featured in this piece.

But as the seasoned veterans that we are, we already know that the prestige of the program doesn’t matter when betting on college football.

With this in mind, here are Saturday’s four smartest college football picks, based on value alone, for Week 8.

College Football Picks for Week 8

*College football odds as of Saturday morning

Toledo vs. Buffalo Pick

1 p.m. ET | ESPN+

Toledo vs. Buffalo is a classic case of pro bettors dropping big bucks and moving odds.