The Colorado Buffaloes take on the West Virginia Mountaineers in Morgantown, West Virginia. Kickoff is set for 12:00 p.m. EST on TNT.
West Virginia is favored by -6.5 points on the spread with a moneyline of -225. The total is set at 55.5 points.
Here’s my Colorado vs. West Virginia prediction and college football picks for Saturday, November 8, 2025.
Colorado vs West Virginia Prediction
- Colorado vs. West Virginia Pick: West Virginia 1H -3.5 (-110, bet365)
My West Virginia vs. Colorado best bet is on the Mountaineers to cover in the first half. Find the best line available on our live NCAAF odds page.
Colorado vs West Virginia Odds
| Colorado Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+6.5 -110 | 55 -110o / -110u | +195 |
| West Virginia Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-6.5 -110 | 55 -110o / -110u | -240 |
- Colorado vs West Virginia point spread: West Virginia -6.5 (-110), Colorado +6.5 (-110)
- Colorado vs West Virginia over/under: 55.5 (-110o / -110u)
- Colorado vs West Virginia moneyline: Colorado +195, West Virginia -240
Colorado vs West Virginia Preview
Colorado Buffaloes Betting Preview: Critical Turning Point for Sanders's Men
The Deion Sanders run in Boulder appears to be fizzling out down the stretch of the 2025 season.
Colorado played two quality opponents well this year, losing 27-20 to 8-1 Georgia Tech and 24-21 to 8-0 BYU. It kept pace with TCU until the end and even beat Iowa State.
And then the bye week passed.
Did Sanders tell his team that he was leaving after the season? Did the whole team decide the season was over? Did a single player pick up a football?
Who knows, but coming out of the bye, Colorado has been beaten twice into oblivion by Utah and Arizona by a combined score of 105-24.
A previously serviceable defense went right out the window. All of a sudden, nobody in the back seven knows how to tackle, and scoring the ball on the Buffs hasn't been this easy since 2022. It was clear nobody on the Colorado sideline had any interest in playing the past two games.
On offense, it's another change. This is the second time this season that Sanders benched Kaidon Salter, this time in favor of youngster Juju Lewis. Lewis threw 17 passes in garbage time against the Wildcats, completing nine of them for 121 yards and a touchdown.
This Colorado roster lacks weapons. It also hasn't improved the run game a lick. Without the offense in gear (it ranks 89th in points per drive), this team is fighting an uphill battle to improve on its current three wins; it certainly won't be favored to do so against Arizona State (even without Sam Leavitt) or at Kansas State.
Opposing quarterbacks had a field day against Colorado due to a below-average pass rush that underperformed its season-long sack rate by half (4.2% on the season, down to 2.2% in the last three games). Combine that with the fifth-lowest graded coverage secondary in the country, and you can see why the Buffs allowed 105 points across the past two games.
This week marks a real turning point. Play well, and we can chalk these games up to a rough two-week stretch. Continue getting blown out, and significant underlying issues in Boulder likely come to light.
West Virginia Mountaineers Betting Preview: Fox Jr. Revitalizes WVU's Offense
It took seven games, but it appears the Rich Rodriguez offensive system is beginning to take hold in West Virginia. The run-centric approach was hindered by the loss of top running back Jaheim White early in the season, as well as a rotating quarterback situation based on who was and wasn't healthy.
Freshman Scotty Fox Jr. has taken the reins for the last two weeks and (quite literally) run with them.
Fox ran two scores in and threw for another in a 45-35 upset win over Houston last week as a 7.5-point home underdog. Those 35 points were the most a Willie Fritz-led Houston team has allowed in two years in Big 12 play.
The week before, West Virginia kept things close with TCU as 16.5-point home 'dogs, losing 23-17. The Mountaineers managed just 41 rushing yards in that TCU game, but Fox threw for 300 yards and two scores in the effort.
Perhaps it's too small a sample to declare West Virginia "turning a corner" at 3-6 with one win in league play. However, the last two weeks have shown marked improvement on either offense or defense, although not quite both together in one game yet.
Rodriguez's system is RPO-based and complex – it takes players time to learn. Time has passed, and it appears Fox is feeling comfortable in the system.
It all comes down to the offensive line.
Last week, West Virginia dominated the line of scrimmage on offense, leading to 250 rushing yards on 53 attempts. If RichRod could draw up a perfect game plan, it was that.
Week 11 really stands as the last obvious shot at putting a complete game together for the 'Neers. Beyond that is Arizona State (away) and top-10 Texas Tech (home) – two teams in potentially vulnerable spots but also two teams that will be favored.
Recency bias could also be at play here with the Mountaineers. After all, they're just three weeks removed from getting stomped by UCF, 45-13, and other games on the ledger like a 41-10 loss at Kansas and a subsequent 48-14 beatdown at the hands of Utah.
However, in three of the last four games, West Virginia appears to be improving. And this week against Colorado, that improvement could come to a head.
Colorado vs West Virginia Pick, Betting Analysis
The play in this game is a combination of fading a Colorado team that appears to be on the edge of total collapse (if not already there) and West Virginia playing quite a bit better than it did earlier in the year.
In the last two games, Colorado was out-scored in the first half a combined 81-7.
There's no attempt at playing any defense, some of the worst tackling in the FBS, and an offense stuck in neutral. Utah has cleaned up its last few opponents, but Arizona is a middle-of-the-pack Big 12 opponent that was 1-3 in league play entering the game.
This is a team that's fully mailed in their season.
West Virginia, on the other hand, played TCU to a 23-17 finish, then sprung a 45-35 upset over Houston on the road in its last two games. The RichdRod offense may have found its quarterback in Fox, and the offensive line has played significantly better than in games past.
Is that a short two-game sample? Yes. But is it also a possible turning point for the Mountaineers? According to multiple local beats, also yes.
There are two games left after this one, at Arizona State and a finale against top-10 Texas Tech. This is likely West Virginia's last chance at a win in 2025.
A revamped WVU run game and offensive front have a significant advantage against a sinking Colorado run defense. The Buffs rank 110th nationally in Rush Success Rate allowed, and the last two games show a disinterested defensive unit.
If West Virginia is a team on a track to be better both this year and next year, this is a game the Mountaineers clean up early in.
Pick: West Virginia 1H -3.5 (-110, bet365)
