The Florida Gators take on the Kentucky Wildcats in Lexington, Kentucky. Kickoff is set for 7:30 p.m. EST on SEC Network.
Florida is favored by 3 points on the spread with a moneyline of -160. The total is set at 44.5 points.
Here’s my Florida vs. Kentucky prediction and college football picks for Saturday, November 8, 2025.
Florida vs Kentucky Prediction
- Florida vs. Kentucky Pick: Kentucky +3.5 or Better
My Kentucky vs. Florida best bet is on the Wildcats. Find the best line available on our live NCAAF odds page.
Florida vs Kentucky Odds
| Florida Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-3 -115 | 44.5 -110o / -110u | -160 |
| Kentucky Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+3 -105 | 44.5 -110o / -110u | +135 |
- Florida vs Kentucky point spread: Florida -3 (-115), Kentucky +3 (-105)
- Florida vs Kentucky over/under: 44.5 (-110o / -110u)
- Florida vs Kentucky moneyline: Florida -160, Kentucky +135
Florida vs Kentucky Pick
Will Florida show up here after an all-out effort against Georgia that saw the Gators come up just short?
I'm not sure we'll get a fully focused effort from the Gators, who unloaded the clip in a rivalry game last week with games against Ole Miss, Florida State, and Tennessee on deck. Talk about a potentially sleepy spot.
Additionally, Florida will lose the temporary bump from a new coach, which typically lasts only one week. All the latest wrinkles it showed are now on tape as well.
Plus, it's not like DJ Lagway looked great coming out of the bye with some of the offensive changes. I was expecting a much sharper effort. It may just be a lost season for the talented Lagway.
It's also worth noting that Florida will arrive in Lexington with a shorthanded roster.
I thought wide receiver Eugene Wilson III (who was all the rage during the bye) benefited the most from the new-look offense. He finished with over 100 receiving yards, but he will miss this game due to injury.
The same is true for stud five-star freshman wideout Dallas Wilson.
With the statuses of Aidan Mizell and Vernell Brown III also in doubt, the Gators could be decimated entirely on the outside, which will make life much easier for a Kentucky defense that's much stronger against the run (top-20 adjusted run defense among all P4 teams).
Kentucky's offense also has more juice since making a quarterback change to Cutter Boley, who has looked better following the bye week.
Boley won't have to worry about much pressure against Florida (118th in pressure rate), and the entire offense is predicated on generating yards after the catch, which is the exact way teams want to attack this very stingy Florida defense.
The 'Cats have been playing with a lot of confidence over the past month. They should have beaten Texas at home and just pulled off an upset on the road against Auburn.
I'm not worried about their care level at home against a rival. Ultimately, adjusting for the spot and injuries, I don't think this line should be over a field goal.
Trending: Before last year's loss in Gainesville, Kentucky had covered seven straight in this rivalry. In other words, I don't really have a nice trend worth highlighting here.
Pick: Kentucky +3.5 or Better
