The Pittsburgh Panthers take on the Syracuse Orange in Syracuse, NY. Kickoff is set for 7:30 p.m. ET on ACC Network.
Pitt is favored by -10.5 points on the spread with a moneyline of -425. The total is set at 55 points.
Here’s my Pitt vs. Syracuse prediction and college football picks for Saturday, October 18, 2025.
Pitt Panthers vs Syracuse Orange Prediction, Picks
- Pitt vs. Syracuse Pick: Pitt -10.5
My Syracuse vs. Pitt best bet is on the Panthers to cover the spread. Find the best line available on our live NCAAF odds page.
Pitt vs Syracuse Odds, Line, Spread
| Pitt Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-9.5 -110 | 54.5 -115o / -105u | -350 |
| Syracuse Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+9.5 -110 | 54.5 -115o / -105u | +280 |
- Pitt vs Syracuse Spread: Pitt -9.5, Syracuse +9.5
- Pitt vs Syracuse Over/Under: 54.5
- Pitt vs Syracuse Moneyline: Pitt ML -350, Syracuse ML +280
Pitt vs Syracuse NCAAF Week 8 Pick
After losing to Louisville at the end of September, quarterback Eli Holstein was benched in favor of Mason Heintschel.
Since then, the Panthers have won two straight ACC games, including one over No. 25 Florida State on the road.
The Orange have lost two straight, and our very own Evan Abrams has a system that believes Syracuse is not only going to lose a third straight affair, but that Pitt is going to blow its opponent out. That would mean two straight wins on the road for the Panthers.
The system — "Road Trip Luck, Low O/U Level II" — has a strong overall return on investment of 16%, creating some value on this selection.
"Road Trip Luck Low O/U Level II" is a college football system that focuses on conference games where recent turnover fortune skews perception.
When an opponent has benefited from positive turnover margins in its last two games, the market often inflates its chances of continuing that success, even though turnovers tend to regress.
The system looks at situations where the other team is on a losing streak away from home, which further tilts public opinion toward the opponent despite underlying weaknesses.
By narrowing in on games with closing totals of 55.5 or lower, scoring expectations are already modest, which makes it harder for supposed favorites to pull away and cover inflated numbers.
These conditions create opportunities to fade turnover driven perception and back teams that are undervalued in lower-scoring conference matchups.
Pick: Pitt -10.5
