The Southern Miss Golden Eagles take on the Louisiana Tech Bulldogs in Ruston, LA. Kickoff is set for 7:30 p.m. ET on ESPN+.
Louisiana Tech is favored by -3 points on the spread with a moneyline of -154. The total is set at 51.5 points.
Here’s my Southern Miss vs. Louisiana Tech prediction and college football picks for Saturday, September 20, 2025.
Southern Miss vs LA Tech Prediction
- Southern Miss vs. Louisiana Tech Pick: Southern Miss ML (+135, bet365)
My Louisiana Tech vs. Southern Miss best bet is on the Golden Eagles ML. Find the best line available on our live NCAAF odds page.
Southern Miss vs Louisiana Tech Odds
| Southern Miss Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+3 -105 | 51 -110o / -110u | +135 |
| LA Tech Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-3 -115 | 51 -110o / -110u | -160 |
- Southern Miss vs Louisiana Tech point spread: Louisiana Tech -3
- Southern Miss vs Louisiana Tech over/under: 51 points
- Southern Miss vs Louisiana Tech moneyline: Southern Miss +135, Louisiana Tech -160
Southern Miss vs Louisiana Tech Preview
We here at the Group of 5 Deep Dive love Southern Miss.
We love the coaching upgrades, not just with Charles Huff as head coach, but also with offensive coordinator Blake Anderson working with quarterback Braylon Braxton.
The defense could be excellent in the secondary if everything gels.
Through three games, Southern Miss is 2-1, winning back-to-back games (Jackson State, App State) after losing to Mississippi State in the season opener by 17, a loss that looks much better after a few weeks.
The Golden Eagles’ defense looks significantly improved, especially following their three-interception performance last week.
Meanwhile, Louisiana Tech looks like a clear overachiever through three weeks.
Although they shut out Southeastern Louisiana, hung around with LSU for three quarters in a respectable 23-7 loss, and blew out New Mexico State, I still don’t see the Bulldogs playing well for the rest of the season.
The passing game is a mess. I don’t like either quarterback, as Trey Kukuk is averaging -0.33 EPA per Dropback while Blake Baker is completing less than half of his passes (although he’s more of a risk taker).
Southern Miss defensive coordinator Jason Semore is going to set a few traps for either of these quarterbacks. Plus, he knows how to handle dual-threat quarterbacks, which is important considering Louisiana Tech’s two quarterbacks can do damage with their legs.
I expect Semore’s defense to bottle up Louisiana Tech’s designed quarterback runs while bringing complex pressure packages, forcing either of these quarterbacks to process quickly and beat the Golden Eagles over the top.
I don’t believe either quarterback can do that, and I think the wrong team is favored in this matchup.
Pick: Southern Miss ML (+135, bet365)
