The Stanford Cardinal take on the Virginia Cavaliers in Charlottesville, VA. Kickoff is set for 7:30 p.m. ET on ACC Network.
Virginia is favored by -15.5 points on the spread with a moneyline of -750. The total is set at 49.5 points.
Here’s my Stanford vs. Virginia predictions and college football picks for Saturday, September 20, 2025.
Stanford vs Virginia Prediction
- Stanford vs. Virginia Pick: Under 49.5
My Virginia vs. Stanford best bet is on the under. Find the best line available on our live NCAAF odds page.
Stanford vs Virginia Odds
| Stanford Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+15.5 -110 | 49.5 -105o / -115u | +525 |
| Virginia Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-15.5 -110 | 49.5 -105o / -115u | -750 |
- Stanford vs Virginia point spread: Virginia -15.5
- Stanford vs Virginia over/under: 49.5 points
- Stanford vs Virginia moneyline: Stanford +525, Virginia -750
Stanford vs Virginia Pick, Betting Analysis
After crushing William & Mary last weekend, Virginia plays host to Stanford — which defeated Boston College 30-20 in its last game — in an ACC affair.
According to Evan Abrams' "Night Conf Unders" system, the play for this matchup is on the total — in particular, the under.
Most importantly, this system is +$11,227 with an 11.8% return on investment (ROI) since its inception in 2005.
"Night Conf Unders" is a college football system that takes advantage of slower-paced conference games played in evening windows where scoring expectations are often too high.
These matchups occur in the Central or Eastern time zones with kickoffs between seven and nine at night, a setting that historically produces tighter play and more conservative game plans as teams adjust under the lights.
By focusing on conference contests, the system isolates games with built in familiarity where defenses are better prepared for opponent schemes.
The totals targeted are 66 1/2 or lower, which represent lines high enough to tempt public action on the over, yet still leave room for the under to hit when execution stalls.
With betting percentages spread across both sides and temperatures sitting in a playable range above 60, the environment remains steady without extremes.
The result is a reliable profile where unders cash more often than expected in night conference football.
Pick: Under 49.5
