The Tennessee Volunteers take on the Mississippi State Bulldogs in Starkville, MS. Kickoff is set for 4:15 p.m. ET on SEC Network.
Tennessee is favored by -7.5 points on the spread with a moneyline of -305. The total is set at 63 points.
Here’s my Tennessee vs. Mississippi State predictions and college football picks for Saturday, September 27, 2025.
Tennessee vs Mississippi State Prediction
- Tennessee vs. Mississippi State Pick: Over 63
My Mississippi State vs. Tennessee best bet is on the over. Find the best line available on our live NCAAF odds page.
Tennessee vs Mississippi State Odds
| Tennessee Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-7.5 -110 | 63 -110o / -110u | -305 |
| Mississippi State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+7.5 -110 | 63 -110o / -110u | +245 |
- Tennessee vs Mississippi State point spread: Tennessee -7.5
- Tennessee vs Mississippi State over/under: 63 points
- Tennessee vs Mississippi State moneyline: Tennessee -305, Mississippi State +245
Tennessee vs Mississippi State Picks
Mississippi State's defense has a pass rush outside the top-100 after playing the offenses of Northern Illinois, Alcorn State, Arizona State and Southern Miss.
Quarterback Joey Aguilar should have all day against this Bulldogs defense, but the biggest advantage for Tennessee is on the ground with Star Thomas and DeSean Bishop. Both Thomas and Bishop are averaging 3.9 and 4.8 yards after contact, and that includes a game against Georgia's defense.
Mississippi State ranks outside the top 100 in line yards, creating an easy advantage for this Bulldogs offense.
On the flip side, can Blake Shapen attack a Tennessee coverage unit that ranks 60th? Tennessee predominately runs Tim Banks' Cover 3 scheme.
Shapen has faced (and destroyed) Cover 3 on 71 of his 122 drop backs, posting a 73% success rate and an explosive 28% of the time.
Tennessee allows an explosive one out of every attempts in its Cover 3 scheme.
Brenen Thompson and Anthony Evans III are both set up to have big days, leading us to Mississippi State contributing to the over in this spot.
Pick: Over 63
Where To Watch Tennessee vs. Mississippi State Live
- Time: 4:15 p.m. ET
- TV: SEC Network
- Location: Davis Wade Stadium at Scott Field, Starkville, Mississippi
