The South Florida Bulls take on the Miami Hurricanes in Miami Gardens, Florida. Kickoff is set for 4:30 p.m. EDT on The CW.
Miami is favored by 17.5 points on the spread with a moneyline of -850. The total is set at 57.5 points.
Here’s my USF vs. Miami prediction and college football picks for Saturday, September 13, 2025.
USF vs Miami Prediction
- USF vs. Miami Pick: Miami -17 Or Better
My Miami vs. USF best bet is on the Hurricanes to cover. Find the best line available on our live NCAAF odds page.
USF vs Miami Odds
| S. Florida Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+17.5 -110 | 57.5 -110o / -110u | +550 |
| Miami (FL) Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-17.5 -110 | 57.5 -110o / -110u | -800 |
- USF vs Miami point spread: Miami -17.5 (-110), USF +17.5 (-110)
- USF vs Miami over/under: 57.5 (-110o / -110u)
- USF vs Miami moneyline: S. Florida +550, Miami -800
USF vs Miami Pick, Betting Analysis
I hate to fade my beloved Bulls, who I backed preseason to win the American. They undoubtedly have the best resume in all of college football to date with a pair of ranked wins over Boise State and Florida.
However, I have to get in front of the train in just a brutal situational spot.
While USF comes off two massive games, Miami will come into this one riding high after a win over Notre Dame, followed by an early-season bye week.
I wouldn't be surprised if USF wears down hard in the second half, as it has done in past seasons against Power 4 competition.
I was super impressed by the Hurricanes on both sides of the ball in their opener against Notre Dame. The defense looks substantially improved under new defensive coordinator Corey Heatherman and an influx of transfer talent on the back end. Miami's dynamic duo at defensive end should also cause the South Florida offensive line all kinds of problems.
On the other side of the ball, quarterback Carson Beck looked spectacular (and healthy) in his season debut. He also gets to work behind a dominant offensive line that should control the line of scrimmage and has a bevy of explosive weapons on the outside that should win their one-on-one matchups.
I'm not here to shortchange what USF has accomplished. The Bulls are the rightful favorite, as of this moment, to secure the Group of 5 playoff spot, but they did get a bit fortunate against Boise State with turnovers. I also think the Bulls caught a Billy Napier team taking them lightly last week.
Lastly, I do have a ton of respect for Alex Golesh, who plays to win these types of games. He's not going to get conservative and try to keep it within a respectable margin, which increases the chances of a Miami beatdown in an ideal situational spot.
Pick: Miami -17 Or Better
