New bettors who use the bet365 bonus code during sign-up claim $200 in bonus bets after a $10 wager, win or lose. The offer runs all week and gets extra weight on Saturday, when No. 4 Ohio State travels to No. 5 Indiana for a Big Ten showdown at noon ET on FOX from Memorial Stadium in Bloomington. Bettors who register before kickoff lock in the bonus bets and enter the market with real buying power for Ohio State vs. Indiana.
Entering this matchup at 6-0, Indiana is also riding a 22-game winning streak as the reigning national champion under head coach Curt Cignetti, while Ohio State counters at 5-1, fresh off a stretch that restored its spot among the nation's top four teams. If you're looking for more action on campus throughout the day, Florida vs. Texas (12 p.m. ET, ABC) kicks off at the same time as Ohio State-Indiana, while Alabama vs. Tennessee (3:30 p.m. ET, ABC) and Missouri vs. Ole Miss (3:30 p.m. ET, SEC Network) battle in the mid-afternoon, while Notre Dame vs. BYU (7:30 p.m. ET, ABC) lock horns out West in primetime.
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bet365 CFB Odds: Preview & Prediction for Ohio State vs. Indiana
Ohio State opened as a 4-point road favorite, and the line settled at -3.5 after a week of two-way action, with the total sitting at 50.5.
| Market | Ohio State Buckeyes | Indiana Hoosiers |
|---|---|---|
| Spread | -3.5 (+102) | -3.5 (-122) |
| Moneyline | -157 | +132 |
| Total Points | Over 50.5 (-109) | Under 50.5 (-112) |
Kickoff for Ohio State vs. Indiana is at 12 p.m. ET on Saturday, October 17, 2026. Always check bet365 for the most up-to-date odds before the game begins.
Ohio State vs. Indiana Preview
The Buckeyes' attack leans heavily on its top perimeter target but still produces points at an elite clip behind Sayin. Both defenses have shown vulnerability to explosive passing attacks, and that trend points to a game that climbs well past the total. The matchup sets up as a genuine shootout between two top-five offenses that rarely punt.
Ohio State's case for covering -3.5 starts with its away performance this year, where the offense has controlled tempo against ranked opponents and avoided the turnovers that derailed previous road trips in conference play. Indiana's 22-game streak reflects real quality, but much of it came against competition that could not match Ohio State's defensive front seven, which ranks among the conference's best at limiting explosive runs. Sayin's efficiency numbers suggest he can sustain drives against Indiana's secondary, and that edge should hold up in a tight, emotional environment at Memorial Stadium. The Buckeyes also bring a deeper defensive line rotation that can wear down an Indiana offensive front over four quarters.
Indiana's path to covering relies on its home crowd and Cignetti's track record against ranked opponents, but Ohio State has answered bigger road tests this season without blinking. The pick leans toward the Buckeyes finding enough separation late to clear the number, with the final score settling in the 31-27 range. Bettors eyeing the total should also track early pace, since a fast start from either offense usually confirms the over.
Ohio State vs. Indiana Prediction: Ohio State -3.5 (-102)
If you like our content and picks, sign up with bet365 using the bet365 bonus code to claim the $200 bonus and start betting on Ohio State vs. Indiana.
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