The Polymarket promo code (ACTION) is perfect to use on Ohio State's trip to defending national champion Indiana, and this Ohio State vs Indiana prediction rounds up our best CFB picks today.
- Ohio State arrives at 5-1 overall and 3-0 in Big Ten play, ranked No. 4 and looking for payback after Indiana beat the Buckeyes in last season's Big Ten Championship Game.
- Indiana sits at 6-0 and 3-0 in conference play, ranked No. 5 as the defending national champion, but without Heisman winner Fernando Mendoza, who left for the NFL draft.
Here is our full Summary Picks Table from the live Polymarket board before we break down every trade, part of our CFB best bets today for this Big Ten Championship rematch, drawing on the best CFB prediction markets available for this game.
| 🏈 CFB Prediction | 🏷️ Position | Price | 🤑 Return on $100 | 📈 Trade It |
|---|---|---|---|
| OHIOST ML | Yes | 62¢ | $159.45 | Trade it on Polymarket! |
| IND +3.5 (OHIOST -3.5 NO) | No | 53¢ | $186.02 | Trade it on Polymarket! |
| Under 50.5 (Over NO) | No | 52¢ | $189.54 | Trade it on Polymarket! |
| OHIOST -3.5 | Yes | 49¢ | $200.96 | Trade it on Polymarket! |
| Over 50.5 | Yes | 49¢ | $200.96 | Trade it on Polymarket! |
| IND ML | Yes | 39¢ | $251.72 | Trade it on Polymarket! |
Read our dedicated Polymarket review to learn more about this exchange, or check out more prediction market promo codes for other platforms.
Best NCAAF Picks Today for Ohio State vs Indiana Prediction Markets
Every pick below is a real trade available through best prediction market apps, part of our best college football market picks today for this entire NCAAF slate.
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Best Moneyline Pick Today – Ohio State
| 🏈 CFB Prediction | 🏷️ Position | Price | 🤑 Return on $100 | 📈 Trade It Now |
|---|---|---|---|
| OHIOST ML | Yes | 62¢ | $159.45 | Trade it now on Polymarket! |
Ohio State's only blemish this season is a one-point road loss at Texas, and the Buckeyes have rattled off wins over Illinois, Kent State and Iowa since, playing some of the best offensive football in the country.
Indiana is undefeated, but the Hoosiers have done most of their damage against a soft early schedule, and now lose Heisman winner Fernando Mendoza under center, leaving a less proven arm to handle Ohio State's defensive front on the road. At a $100 buy near 62 cents, this trade works out to roughly 161 shares, with Polymarket's stated payout at $159.45.
- If Ohio State wins outright: profit of $159.45.
- If Indiana wins instead: the $100 stake is a total loss.
It is the shortest price on the entire board, but it still pays back more than half your stake in pure profit on the favorite in this Big Ten Championship rematch.
Best Moneyline Pick Today – Indiana
| 🏈 CFB Prediction | 🏷️ Position | Price | 🤑 Return on $100 | 📈 Trade It Now |
|---|---|---|---|
| IND ML | Yes | 39¢ | $251.72 | Trade it now on Polymarket! |
Indiana is 6-0 for a reason, and a defending national champion playing its first true road test of the season at home in Bloomington still has a case even against a hotter Ohio State team.
The Hoosiers' defense has been stout all year, and a raucous Memorial Stadium crowd for this title-game rematch gives Indiana every incentive to play its best football of the season. At 39 cents, a $100 buy is roughly 256 shares, with the stated payout at $251.72.
- If Indiana wins outright: profit of $251.72.
- If Ohio State wins instead: the $100 stake is a total loss.
A true underdog price that still pays back well over 2.5 times your stake if the defending champs defend their home turf.
Best Spread Pick Today – Ohio State -3.5
| 🏈 CFB Prediction | 🏷️ Position | Price | 🤑 Return on $100 | 📈 Trade It Now |
|---|---|---|---|
| OHIOST -3.5 | Yes | 49¢ | $200.96 | Trade it now on Polymarket! |
Ohio State's offense has been one of the more efficient units in the country this season, and the Buckeyes have covered larger numbers than this in four of their six games.
Indiana's defense has faced mostly overmatched competition, and Ohio State's talent advantage up front should show up in a game that is tighter on the scoreboard than on the field. At a $100 buy near 49 cents, this works out to roughly 204 shares, with the stated payout at $200.96.
- If Ohio State wins by more than 3.5 points: profit of $200.96.
- If they don't cover: the $100 stake is a total loss.
Close to a coin flip on the number, but the payout still covers your full stake and then some.
Best Spread Pick Today – Indiana +3.5
| 🏈 CFB Prediction | 🏷️ Position | Price | 🤑 Return on $100 | 📈 Trade It Now |
|---|---|---|---|
| IND +3.5 (OHIOST -3.5 NO) | No | 53¢ | $186.02 | Trade it now on Polymarket! |
Indiana's home crowd and the extra motivation of hosting the team that nearly denied them a perfect season give the Hoosiers a real shot at keeping this one within a field goal.
A defense that has forced its share of mistakes against lesser competition still has a chance to slow down Ohio State's offense enough to cover a number this close. At 53 cents, a $100 buy is roughly 189 shares, with the stated payout at $186.02.
- If Indiana covers the 3.5 points: profit of $186.02.
- If Ohio State wins by more than a field goal: the $100 stake is a total loss.
Basically a coin flip in either direction, and the shorter price side of this same contract still returns just under double your money.
Best Total Pick Today – Over 50.5
| 🏈 CFB Prediction | 🏷️ Position | Price | 🤑 Return on $100 | 📈 Trade It Now |
|---|---|---|---|
| Over 50.5 | Yes | 49¢ | $200.96 | Trade it now on Polymarket! |
Ohio State's offense has pushed past 40 points three times already this season, and Indiana has had little trouble finding points of its own against a lighter schedule.
Two offenses playing at a fast pace, in front of a loud crowd desperate for points on both sides, points toward a game that can clear this number without much trouble. At a $100 buy near 49 cents, this works out to roughly 204 shares, with the stated payout at $200.96.
- If the final score tops 50.5 combined points: profit of $200.96.
- If it doesn't: the $100 stake is a total loss.
Another near coin-flip price that still pays out just over double your stake.
Best Total Pick Today – Under 50.5
| 🏈 CFB Prediction | 🏷️ Position | Price | 🤑 Return on $100 | 📈 Trade It Now |
|---|---|---|---|
| Under 50.5 (Over NO) | No | 52¢ | $189.54 | Trade it now on Polymarket! |
Both defenses have had moments of real stinginess this season, and a title-rematch atmosphere can sometimes tighten things up early as both sides play it close to the vest.
If either staff leans conservative to protect a lead in front of its home or road crowd, this number has a path to staying under. At 52 cents, a $100 buy is roughly 192 shares, with the stated payout at $189.54.
- If the final score stays under 50.5 combined points: profit of $189.54.
- If it goes over: the $100 stake is a total loss.
The flip side of a tight number, still paying back just under double your money.
CFB Best Bets Today: Team Total Points for Ohio State vs Indiana
Beyond the game lines, Polymarket also has team total points markets open for this one, and these team total points predictions line up with each offense's actual scoring pace this season.
- Indiana (Total Points Over 22.5: Yes 57¢): the Hoosiers have cleared this mark in every game so far this season behind a balanced offensive attack.
- Ohio State (Total Points Over 26.5: Yes 57¢): the Buckeyes have topped this number in four of six games, with their lone sub-par output coming in the loss at Texas.
Only the Over side was priced with a live ticket on either team's board, so these are the two team total trades we are making for this game.
What's Moving the NCAAF Odds Market
NCAAF Odds for this game have stayed tight because of how evenly matched these two Big Ten contenders look on paper, even with Ohio State as the short favorite.
Ohio State's talent and depth, especially after adding the Texas loss as its only real blemish, is why the Buckeyes sit as the shorter price despite Indiana's unbeaten record.
Indiana's spot as defending national champion and its home crowd for this title-game rematch is exactly why the Hoosiers are still live on the spread and the moneyline both, even without Fernando Mendoza under center.
The total sitting right around 50.5 reflects two offenses that have scored early and often this season, tempered slightly by two defenses capable of forcing a stop when it matters.
How to Trade These CFB Predictions on Polymarket
Ready to get in on this Ohio State vs Indiana prediction yourself? Here's exactly how to claim the bonus and start trading:
- Read a comprehensive Polymarket review to understand how this exchange operates.
- Follow this guide to trading on Polymarket to learn how to buy your first "Yes" or "No" contract.
- Monitor the relevant tab on Polymarket to stay ahead of the live order book movements.
- When you're ready, sign up with Polymarket promo code ACTION
to get started!
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Final Thoughts: Best College Football Picks Today
This Big Ten Championship rematch carries real weight, with Indiana defending both a national title and a home field it has not yet had to protect against a team this talented.
Ohio State's moneyline and spread both offer solid value given how the Buckeyes have played since their lone loss at Texas, while the total sits right in the middle of what two fast-moving offenses can produce.
For more on how these markets work, check out NCAAF Futures before kickoff.
Ohio State vs Indiana Predictions – FAQs
What are the best NCAAF picks today for Ohio State vs Indiana? Our top plays lean on Ohio State's moneyline and spread given the Buckeyes' form since their only loss, while Indiana's spread and moneyline both offer value as the defending champion defends home field.
What is the Ohio State vs Indiana spread and total? Ohio State is priced at -3.5 on the spread, with Indiana getting the same number on the other side of that contract, and the total sits at 50.5 combined points.
How do I use the Polymarket promo code on this game? Create a Polymarket account, make a qualifying deposit, and enter the current promo code to unlock a trading bonus before kickoff.
What are the best college football picks today on this board? Beyond the game lines, Indiana and Ohio State team total points props are both live, with the market favoring the Over on each team's individual scoring number.
What do the CFB odds say about Ohio State vs Indiana? The market leans Ohio State on the moneyline and spread, a reflection of the Buckeyes' overall talent edge even against an undefeated Indiana team.
Where can I find more NCAAF odds and CFB predictions today? Beyond this game, Action Network's NCAAF odds and futures pages cover every other matchup and market live across the full college football slate.
Are these NCAA predictions based on real money trades? Yes. Every pick in this piece reflects an actual trade ticket pulled from the live Polymarket board for this specific game, not a theoretical line.
What are the top college football predictions for this rematch? Ohio State covering the spread and both teams clearing their individual scoring totals are the picks that line up best with how each offense has performed this season.
When does Ohio State play Indiana this week? This Big Ten Championship rematch is set for Saturday at Memorial Stadium in Bloomington, Indiana, as part of Week 7 of the college football season.
Why is this considered one of the top CFB best bets today? Two top-five teams, a defending national champion defending its home field, and a Big Ten Championship rematch storyline all make this one of the most bet-on games of the week.
