Bills vs. Rams Anytime Touchdown Scorer, Betting Promos, Picks and Predictions

Kickoff for Bills vs. Rams is at 8:15 p.m. ET on Monday, October 12, 2026. Always check your preferred online sportsbook for the most up-to-date odds before the game begins.

Bills vs. Rams Anytime Touchdown Scorer Picks & Predictions

Monday Night Football brings together two offenses loaded with touchdown equity, and the Bills-Rams matchup (3.5-point Rams favorites, 54.5 total) should produce plenty of trips to the end zone. Here are four anytime touchdown scorers to watch tonight. The sportsbook/price listed next to the player offers the best bang for your buck.

Josh Allen, QB – Bills (-115, DraftKings)

Allen leads the NFL with seven rushing touchdowns in just four games, a pace that puts him on track to shatter his own single-season quarterback record. He’s scored a rushing touchdown in every game this season, including a two-yard plunge last week against New England, even in a loss. His passing has hit a rough patch, with three interceptions in his last two outings, but his ground game has consistently papered over those mistakes for bettors and fantasy managers alike. The matchup isn’t a layup on paper: the Rams have allowed just one rushing touchdown all season, the second-stingiest mark in the league, but LA lacks the personnel to slow Allen, given his ability to create yardage near the goal line with his legs.

Kyren Williams, RB – Rams (-155, DraftKings)

Williams has scored a touchdown in back-to-back games, punctuating last week’s comeback win over Philadelphia with two fourth-quarter touchdown runs that sealed the victory. He’s handled a team-high workload in the Rams’ backfield, and despite carrying fewer carries overall than last year, his touchdown rate remains elite — he’s found paydirt in 50% of his games this season. Sean McVay has made clear that Williams is the first option near the goal line, with backup Blake Corum limited to mop-up duty in blowout game scripts. Buffalo’s defense has shown cracks against the run, and with the Rams expected to control tempo in a shootout-potential game, Williams projects for his usual share of high-value touches inside the 10. His early-down work and red-zone trust make him one of the safer anytime touchdown bets on the board tonight.

Puka Nacua, WR – Rams (-118, betPARX)

Nacua looked fully healthy on his return from a groin/hip injury last week, catching nine passes for 125 yards and a two-yard rushing touchdown against the Eagles. He’s now completely off the injury report heading into tonight, and McVay has already shown a willingness to get him the ball on designed goal-line runs in addition to his usual route-running duties. Buffalo’s defense has been generous through the air, already surrendering 10 passing touchdowns in just four games, a volume that should funnel more red-zone opportunities to Los Angeles’ clear top target. Nacua enters as the betting market’s WR2 for the week and has drawn 21 targets on just 69 routes run this season, a target rate that places him firmly in the game’s highest-value touchdown tier. With Stafford leaning on him as a security blanket in a high-scoring environment, Nacua has two ways to cash tonight: receiving and rushing.

Keon Coleman, WR – Bills (+260, BetMGM)

Coleman is coming off the best game of his young career, hauling in six catches for 116 yards and a touchdown against New England after DJ Moore exited with a shoulder injury. Moore is questionable tonight and was limited in practice all week, which could push Coleman into a featured role for a second straight game. In the two games this season when Moore was hampered, Coleman's target share jumped into the low-20-percent range, with multiple red-zone looks each time. The matchup carries some risk, as the Rams will likely shadow Buffalo’s top available receiver with their top cornerback, but Coleman has shown he can win contested catches regardless of coverage. With his role trending upward and a touchdown already punched in each of his last two outings, Coleman offers solid value as a change-of-pace scorer alongside Buffalo’s bigger names.