College Football Today Best Bets: Trade OSU-Indiana, Alabama-Tennessee, Notre Dame-BYU

This edition of my college football today best bets rounds up three Top 10 matchups worth trading. The Polymarket promo code (ACTION) is perfect to sign up with ahead of this loaded Week 7 slate today.

• The three games I give my college football best bets for are Ohio State vs. Indiana, Alabama vs. Tennessee, and Notre Dame vs. BYU.
• All three games on this card carry real College Football Playoff stakes, with ranked teams on both sides of every matchup.
• Polymarket's board shows steady volume moving across every Moneyline, Spread, and Total market on the slate, a sign bettors are treating these as some of the week's sharpest lines.

Before I give you my full breakdown, here's a complete board across the best prediction markets for this week's college football today best bets.

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College Football Today Best Bets: My Top Polymarket Picks for the Week 7 CFB Slate

Every pick below is a real trade I backed straight on Polymarket's order book. Follow along on the best prediction market apps or browse the full NCAAF board for more.

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Three ranked matchups headline this week's college football today best bets, and Polymarket has real money attached to every line below.

Ohio State vs. Indiana Prediction

Ohio State enters as the four spot in the AP poll at 5-1, looking to avenge last season's Big Ten title game loss to Indiana. The Hoosiers come in unbeaten at 6-0, riding a top-five ranking of their own and a defense that's been stingier than its reputation suggests.

This is the marquee game of the week, and Polymarket's board reflects a market that leans Ohio State but isn't fully sold on a blowout.

Best Moneyline Pick Today – Ohio State Moneyline

Ohio State's offense has been one of the most efficient units in the country through six weeks, and Indiana's resume is built more on close finishes than dominant wins.

At 62 cents, the market is pricing Ohio State as a clear but not overwhelming favorite, which lines up with a game most expect to be competitive into the fourth quarter.

A $100 trade at 62 cents buys roughly 161 shares, and Polymarket's ticket shows the real payout at $157.14 once Ohio State wins.

• If Ohio State wins: the trade returns $157.14.
• If Indiana wins: the full $100 stake is lost.

That's a payout multiple of roughly 1.57x on the Buckeyes.

Best Spread Pick Today – Ohio State -3.5

Ohio State covering by a field goal or more is close to a coin flip on Polymarket, which tracks with a game many expect to be decided late.

Indiana has leaned on its defense to keep games tight all season, so a backdoor cover or outright upset is squarely in play here.

A $100 trade at 49.5 cents buys roughly 202 shares, and the ticket shows a real payout of $195.17 if Ohio State covers.

• If Ohio State covers -3.5: the trade returns $195.17.
• If Ohio State fails to cover or loses: the full $100 stake is lost.

That's just under a 2x payout multiple on the spread.

Best Total Pick Today – Under 49.5

Both of these defenses have been better than their names suggest, and a game this tense tends to play out with fewer possessions than a shootout.

This is the No side of the Over 49.5 contract, and the price suggests the market is split almost evenly on which way the total breaks.

A $100 trade at 49 cents buys roughly 204 shares, and the ticket shows a real payout of $197.10 if the final total stays under 49.5.

• If the total goes under 49.5: the trade returns $197.10.
• If the total goes over: the full $100 stake is lost.

That's just under a 2x payout multiple on the under.

Up next, we head to Tuscaloosa for another ranked showdown, but first, is worth a look if you haven't claimed it yet.

Alabama vs. Tennessee Prediction

Alabama sits at 5-1 and ranked in the top six nationally, hosting the Third Saturday in October rivalry game at home. Tennessee comes in at 5-1 as well, ranked in the mid-teens, looking to pull off a road upset in a series it's trailed in recent meetings.

This is one of the sport's oldest rivalries, and Polymarket's board shows Alabama as a clear favorite across every market.

Best Moneyline Pick Today – Alabama Moneyline

Alabama's offense has found another gear at home this season, and Tennessee's road record hasn't matched its performance in Knoxville.

At 75 cents, the market is treating this as a comfortable but not lopsided win for the Crimson Tide.

A $100 trade at 75 cents buys roughly 133 shares, and the ticket shows a real payout of $131.05 if Alabama wins.

• If Alabama wins: the trade returns $131.05.
• If Tennessee wins: the full $100 stake is lost.

That's a payout multiple of roughly 1.31x on the Crimson Tide.

Best Total Pick Today – Over 51.5

Both offenses have shown they can move the ball in chunks this season, and a rivalry game of this magnitude rarely stays conservative for four quarters.

At just under 53 cents, the market gives a slight edge to the over, consistent with two teams that trade points more often than they trade punts.

A $100 trade at 52.77 cents buys roughly 189 shares, and the ticket shows a real payout of $183.49 if the total goes over 51.5.

• If the total goes over 51.5: the trade returns $183.49.
• If the total goes under: the full $100 stake is lost.

That's a payout multiple of roughly 1.83x on the over.

Best Spread Pick Today – Alabama -7.5

Alabama's home-field advantage in this rivalry has been significant in recent years, and a two-score cushion feels earned given the talent gap on paper.

Tennessee has kept games close on the road this season, but hasn't faced a defensive front quite like Alabama's.

A $100 trade at 51.5 cents buys roughly 194 shares, and the ticket shows a real payout of $187.84 if Alabama covers -7.5.

• If Alabama covers -7.5: the trade returns $187.84.
• If Alabama fails to cover or loses: the full $100 stake is lost.

That's a payout multiple of roughly 1.88x on the spread.

From Tuscaloosa, we head out west to Provo for the night game, and is still live if you want to get a trade in before kickoff.

Notre Dame vs. BYU Prediction

Notre Dame is unbeaten at 6-0 and ranked second nationally, looking like one of the best teams in the sport through six weeks. BYU sits at 5-0 and ranked eighth, hosting the Irish in Provo for the first time in over two decades.

This is the signature non-conference game of the week, and Polymarket's board has Notre Dame as a heavy favorite on the road.

Best Moneyline Pick Today – Notre Dame Moneyline

Notre Dame has looked like one of the most complete teams in the country this season, and BYU, while unbeaten, hasn't faced a roster with this much depth yet.

At 79 cents, the market treats this as close to a lock, which matches a talent gap that's shown up on film all year.

A $100 trade at 79 cents buys roughly 127 shares, and the ticket shows a real payout of $124.75 if Notre Dame wins.

• If Notre Dame wins: the trade returns $124.75.
• If BYU wins: the full $100 stake is lost.

That's a payout multiple of roughly 1.25x on the Irish.

Best Total Pick Today – Under 46.5

Both of these teams have leaned on defense and ball control more than explosive offense this season, and a true road environment in Provo tends to slow games down further.

This is the No side of the Over 46.5 contract, and the slight edge toward the under lines up with how both teams have played complementary football all year.

A $100 trade at 52 cents buys roughly 192 shares, and the ticket shows a real payout of $186.09 if the total stays under 46.5.

• If the total goes under 46.5: the trade returns $186.09.
• If the total goes over: the full $100 stake is lost.

That's a payout multiple of roughly 1.86x on the under.

Best Spread Pick Today – Notre Dame -10.5

A double-digit number on the road is never automatic, but Notre Dame's margins this season suggest the Irish are comfortable pulling away in the second half.

BYU's home environment is one of the toughest in the country, which keeps this line close to a true coin flip despite the talent gap.

A $100 trade at 50.5 cents buys roughly 198 shares, and the ticket shows a real payout of $191.42 if Notre Dame covers -10.5.

• If Notre Dame covers -10.5: the trade returns $191.42.
• If Notre Dame fails to cover or loses: the full $100 stake is lost.

That's a payout multiple of roughly 1.91x on the spread.

That wraps our picks for the slate, and is still the quickest way to get in on any of the nine trades above.

What's Moving the Market

Notre Dame's moneyline has held steady above three-quarters of a cent all week, a sign the market isn't worried about a letdown spot on the road against an unbeaten BYU team.

Ohio State vs Indiana has seen the most two-way action of the three games, with the spread tightening slightly as more volume has come in on Indiana's side of the ledger.

Alabama's number against Tennessee has held firm, reflecting a market that sees this as a comfortable, if not dominant, home win in a rivalry that's historically closer on paper than on the field.

For the full slate of lines across every game this week, check the NCAAF Odds page, and track broader line movement on the prediction markets hub.

How to Trade These Picks on Polymarket

Ready to get in on this board? Here's exactly how to claim the bonus and start trading college football today best bets:

• Read a comprehensive Polymarket review to understand how this exchange operates.
• Follow this guide to trading on Polymarket to learn how to buy your first "Yes" or "No" contract.
• Monitor the Week 7 CFB tab on Polymarket to stay ahead of live order book movements.
• When you're ready, sign up with Polymarket promo code ACTION to get started!

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Final Thoughts

This week's slate gives college football today best bets a real test case for three very different kinds of favorites: a pick'em-level rivalry game in Columbus, a comfortable road favorite in Tuscaloosa, and a near-lock in Provo.

Nine total trades are covered above across Moneyline, Spread, and Total markets, each sourced straight from Polymarket's own order book rather than an estimate.

For more ways to build out your board, check the NCAAF Futures page or browse more NCAAF Prediction Market Promo Codes before kickoff.

Polymarket Promo Code FAQs

What makes this week's college football today best bets worth following?

Every pick in this piece comes from a real Polymarket trade ticket rather than a sportsbook line, meaning prices reflect actual money changing hands on each outcome.

Which games are covered in this week's CFB best bets?

This slate covers Ohio State vs. Indiana, Alabama vs. Tennessee, and Notre Dame vs. BYU, three of the most notable matchups in Week 7 of the college football season.

How do Polymarket's prices work?

Each Polymarket contract is priced in cents, and that price roughly reflects the market's implied probability of that outcome happening, with "Yes" and "No" as the two possible positions.

Is Ohio State or Indiana favored on Polymarket?

Ohio State is the favorite on the moneyline, priced at 62 cents, while the spread between the two teams sits close to even money.

Is Alabama favored over Tennessee?

Yes, Alabama is priced as a clear favorite on the moneyline at 75 cents, with the spread and total both leaning toward the Crimson Tide covering comfortably at home.

Who's favored in Notre Dame vs BYU?

Notre Dame is priced as a heavy favorite at 79 cents on the moneyline, even on the road against an unbeaten BYU team.

How do I use the Polymarket promo code on The Action Network?

Create a Polymarket account through the link in this article, complete the signup process, and enter the promo code during registration to unlock the trading bonus.

Can I trade on Polymarket in my state?

Availability varies by state, so check Polymarket's own terms and your local regulations before signing up to confirm you're eligible to trade.