Philip Rivers starting a primetime NFL game in the year 2025?
A sentence that seemed impossible to type a few short weeks ago has become a reality.
Rivers and the Indianapolis Colts have fallen to eighth in the AFC playoff picture, one spot out of the final postseason berth, and the task doesn't get any easier against the San Francisco 49ers on Monday Night Football (8:15 p.m. ET, ESPN).
Indianapolis is a 5.5-point underdog against San Francisco according to 49ers vs. Colts odds, with Monday's over/under listed at 46.5.
Sixty-five percent of spread bettors are backing San Francisco on Monday night, but is laying the points the smartest Monday Night Football prediction?
We provide the answer below.
Monday Night Football Prediction for 49ers vs. Colts
*Odds as of Monday morning
This is a textbook case of the impact of key numbers in NFL betting.
