Broncos vs. Seahawks Picks, Predictions & Parlay Options

Short rest tends to even things out, and Thursday’s trip to Denver does exactly that for Seattle. The Seahawks arrive at 3-2 after a shootout loss to the 49ers on Sunday, while the Broncos sit at the same mark following a road win over the Chargers. Both teams have shown real flaws through 5 weeks, which makes this NFC vs AFC crossover harder to call than the records alone suggest. Here’s how I’m leaning on the spread, moneyline and total before Thursday’s 8:15 PM ET kickoff. But before we dive in, be sure to check out our Polymarket review, grab the Polymarket promo code, and download the Action Network app for more NFL picks and predictions.

Let's get into my Seahawks vs. Broncos prediction and my NFL predictions for Thursday Night Football.

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SPREAD

Seattle opened as the favorite on the road, and the number has settled at a field goal or less. Covering it is close to even odds on Polymarket, which fits two teams separated by very little through 5 games, Denver has been competitive in every outing this year, including Sunday’s narrow win over the Chargers.

MONEYLINE

Straight up, Seattle holds a real but not overwhelming edge. The Seahawks have the better overall résumé between the two 3-2 teams, but a short week after an emotional loss to San Francisco is its own variable, and Denver gets an extra boost from a home crowd at altitude on a Thursday night.

TOTAL

At 40.5 points, this is one of the lower totals on the board this week, a fair read on two defenses that have each had uneven moments but are facing short-week opponents still shaking off Sunday. Activity is almost split down the middle, with a slight lean toward the Over.

My Pick: Seahwaks -2.5

• Seahawks-Broncos Point Spread: Seahawks 54¢ · Broncos 53¢
• Seahawks-Broncos Total: Over/Under 40.5
• Seahawks-Broncos Moneyline: Seahawks 59¢ · Broncos 58¢

NFL Thursday Night Football Picks

The two franchises haven’t met in the regular season since 2023, when the Broncos pulled off a road win, and this time both sides will wear throwback uniforms for the occasion. There’s also a layer of tension between the coaching staffs: Seahawks coach Mike Macdonald recently accused Broncos counterpart Sean Payton of making threats before their last meeting, giving this one a bit more bite than a typical October matchup between two 3-2 teams.

Seattle’s defense gave up 32 points on Sunday, a number that would normally raise concern, but it came against the NFL’s hottest offense, and the Seahawks still found a way to keep pace behind Sam Darnold and Jaxon Smith-Njigba.

Denver counters with a run game built around J.K. Dobbins and an offense that leans on efficiency over explosiveness, which could struggle to keep pace if Seattle’s passing attack travels well on a short week. On Polymarket, nearly $65,000 has already traded on the moneyline, and Seattle’s side has held a consistent, if modest, lead throughout. I’d rather take the Seahawks to win outright than chase the shorter spread number, since a short-week road team at altitude is exactly the kind of spot where the final margin gets unpredictable.

Pick: Seahawks 

• Seattle is pulling the larger share of activity on the moneyline, with the market giving the Seahawks a real, if not overwhelming, edge to win outright.
• The spread is drawing a tighter, more even split, reflecting how close this matchup is seen on a neutral read of both records.
• Total trading is nearly split down the middle, with a slight lean toward the Over on a number that sits lower than most of this week’s other games.

Seattle Seahawks vs. Denver Broncos is scheduled for 8:15 p.m. ET, live from Empower Field at Mile High in Denver, Colorado. The game is live on Prime Video.