Sunday of NFL Week 5 will come to a close with a battle between the New England Patriots and Buffalo Bills on Sunday Night Football. The game will be broadcast live on NBC at 8:20 p.m. ET; the game will take place at Highmark Stadium.
Below, you can find Sunday Night Football odds and my Bills vs Patriots parlay, which includes the spread and a Drake Maye player prop.
Bills vs Patriots Parlay
- Bills -8.5 (+106)
- Drake Maye 200+ Passing Yards (-230)
Parlay Odds: +210 (bet365)
Bills vs Patriots Odds
Patriots Odds | ||
---|---|---|
Spread | Total | Moneyline |
+7.5 -115 | 49 -110o / -110u | +325 |
Bills Odds | ||
---|---|---|
Spread | Total | Moneyline |
-7.5 -105 | 49 -110o / -110u | -450 |
- Bills vs Patriots Moneyline: Bills -450, Patriots +325
- Bills vs Patriots Over/Under: 49 total points
- Bills vs Patriots Spread: Bills -7.5, Patriots +7.5
Bills vs Patriots Preview, Parlay Picks

Bills -8.5
The Bills have been the gold standard early in the season as they enter Sunday Night Football undefeated.
Josh Allen enters the week as the MVP favorite (+100). He has thrown for 964 yards with a 7:1 TD:INT ratio, plus 159 rushing yards and three touchdowns.
The Bills were heavy favorites against the Saints last week and are over a touchdown favorite in this spot — that isn't a bad thing.
According to our Evan Abrams, teams after closing as a 14-plus-point favorite are 41-28-1 against the spread (ATS) (59%) since 2018, including a 21-13 ATS mark at home.

Drake Maye 200+ Passing Yards
While I have been impressed with Drake Maye early in the season, he draws a challenging road matchup in one of the most difficult atmospheres in football.
Maye has cleared 200 yards in every game this season, even in last week's blowout win over the Panthers.
The game script favors this prop, as New England is likely to play from behind most of the way.
Maye should attempt 30–40 passes and has a strong chance to surpass 200 yards in the second half once the Patriots become one-dimensional. He attempted 36 passes and totaled 261 yards in the full game he played against the Bills last season.
Bills vs Patriots Same-Game Parlay
- Bills -8.5 (+106)
- Drake Maye 200+ Passing Yards (-230)
Parlay Odds: +210 (bet365)