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Buffalo Bills Odds

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Next Bills Game

Game Details
@ Tennessee Titans
Tennessee
location pin
Tue 10/1912:15 AM

Titans vs Bills Odds

More Odds
SpreadTotalMoneyline
BUF
Right Arrow-5.5-110
Right Arrowo53.5-110
Right Arrow-250ML
TEN
Right Arrow+5.5-110
Right Arrowu53.5-110
Right Arrow+200ML

Best Bills Betting Sites

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Bills Injuries

All NFL Injuries
  • Taiwan Jones

    RB

    Taiwan Jones (hamstring) is questionable this week.

    Questionable

  • Matt Milano

    LB

    Matt Milano (hamstring) is questionable this week.

    Questionable

  • A.J. Epenesa

    DE

    A.J. Epenesa (foot) is questionable this week.

    Questionable

  • Marquez Stevenson

    WR

    Marquez Stevenson (Head) is out this week.

    Out

Bills 2021 Schedule

dateopponentscorespreadover/undermoneyline
Nov 7th@JAC----
Oct 31stMIA----
Oct 19th@TEN--5.553.5-250
Oct 11th@KCW 38-20+3 WO 56.5BUF +122
Oct 3rdHOUW 40-0-19 WU 47.5BUF -1548
Sep 26thWASW 43-21-7.5 WO 45.5BUF -334
Sep 19th@MIAW 35-0-3.5 WU 48BUF -185
Sep 12thPITL 16-23-6.5 LU 48PIT -281
Aug 28thGBW 19-0-7.5 WU 37.5BUF -355
Aug 21st@CHIW 41-15+4 WO 37BUF +161

Depth Chart

Right Arrow
Starter2ND3RD4TH
QBJosh AllenMitchell Trubisky
RBDevin SingletaryMatt BreidaZack MossTaiwan Jones
WRStefon DiggsEmmanuel SandersCole BeasleyGabriel DavisIsaiah McKenzieJake KumerowMarquez Stevenson
TEDawson KnoxTommy Sweeney
LTDion DawkinsSpencer Brown
LGJon Feliciano
CMitch MorseRyan Bates
RGCody FordIsaac Boettger
RTDaryl Williams
LDEJerry HughesGregory RousseauEfe Obada
LDTStar LotuleleiVernon ButlerHarrison Phillips
RDTEd OliverJustin Zimmer
RDEMario AddisonA.J. EpenesaCarlos Basham
WLBMatt MilanoA.J. KleinAndre Smith
MLBFe'Zahn EdmundsTyrel DodsonTyler Matakevich
SSJordan PoyerDamar Hamlin
FSMicah HydeJaquan Johnson
PMatt Haack
HMatt Haack
PRIsaiah McKenzieMarquez Stevenson
KRIsaiah McKenzieMarquez Stevenson
LSReid Ferguson
CBTaron JohnsonTre'Davious WhiteLevi WallaceDane JacksonSiran Neal
FBReggie Gilliam
KTyler Bass

Buffalo Bills Player Stats

  • passing yards

    Josh Allen
    1370
    pyds
  • passing touchdowns

    Josh Allen
    12
    ptd
  • rushing yards

    Devin Singletary
    284
    ryds
  • rushing touchdowns

    Zack Moss
    3
    rtd

Buffalo Bills Odds, Bet Types, and Team History

The Buffalo Bills matched a franchise record with 13 wins in 2020. At 13-3, Buffalo won the AFC East for the first time since 1995 and secured the No. 2 seed in the conference. The Bills reached the AFC Championship game before falling to the Kansas City Chiefs. With three playoff appearances in the past four seasons, Buffalo is slowly becoming one of the conference’s more competitive teams.

It should stay that way too now that QB Josh Allen is under contract through 2028. Allen took a major step forward in his third NFL season, earning second-team All-Pro honors after throwing for 4,544 yards and 37 touchdowns with another eight scores on the ground.

Allen’s development played a huge role in Buffalo having the league’s second-best offense, though he also had two All-Pro wideouts to work with. Stefon Diggs cost the Bills four draft picks, including a first rounder, but more than lived up to the billing with a league-best 127 catches for 1,535 yards and eight touchdowns. Cole Beasley did most of his damage in the slot with a career-high 82 receptions for 967 yards and four scores.

Buffalo’s defense finished middle of the pack, allowing 23.4 points per game. All 11 starters from a year ago are back, most notably All-Pro cornerback Tre’Davious White and Pro Bowl linebacker Tremain Edmunds . White broke up 11 passes to go with 1.5 sacks, one interception and two fumble recoveries. Edmunds made 119 total tackles and had two sacks.

The Bills open the 2021 NFL season at home against the Pittsburgh Steelers. You can view the Action Network’s top odds for the game below in addition to an odds comparison for every Week 1 game right here.

Week 6 Odds: Buffalo Bills vs. Tennessee Titans (via BetMGM)

TeamSpreadMoneylineTotal O/U
Buffalo Bills(-5.5)-110-250Over 52.5(-110)
Tennessee Titans(+5.5)+110+200Under 52.5(-110)

More: Matchup Page

Bills Offseason Movement 2021

Trades: none

Draft picks: Gregory Rousseau (EDGE, Miami), Carlos Basham Jr. (EDGE, Wake Forest), Marquez Stevenson (WR, Houston)

Re-signings: Mitch Morse (C, four years), Micah Hyde (S, two years), Jon Feliciano (G, three years), Matt Milano (LB, four years), Daryl Williams (T, three years), Forrest Lamp (G, one year)

Free-agent signings: Emmanuel Sanders (WR, one year), Bobby Hart (T, one year), Matt Breida (RB, one year)

Free-agent losses: Quinton Jefferson (DT, to Raiders)

Bills Rivals

The Bills went 13-3 last year, capturing their first AFC East title since 1995 — a year before Josh Allen was born. Buffalo won all six of its games against division opponents by an average of 13.8 points. Buffalo beat Indianapolis and Baltimore in the postseason before losing to Kansas City in the AFC Championship Game.

The Miami Dolphins finished second in the division at 10-6, though they missed the playoffs in a very competitive AFC. The New England Patriots were third at 7-9 with their fewest wins since 2000. And the New York Jets placed fourth at 2-14, losing 13 straight to open the season before closing it out with wins in two of the last three games.

Find weekly Buffalo Bills odds above. Below you’ll find how to bet on the Bills as well as their complete 2021 schedule, betting trends, performance against-the-spread (ATS), injury history, a fulldepth chart and more.

MORE: Keep up with all Buffalo Bills news

Betting on the Buffalo Bills

Buffalo Bills Point Spreads

Betting point spreads are wagers based on the expectation that a team will win or lose by a certain number of points. The Bills went 13-3 overall but 11-5 against the spread. Buffalo’s 13 wins were by an average of 12.5 points and its three losses were by 12.3 points.

Here’s an example:

  • Jets +3.5 (+110)
  • Bills -3.5 (-110)

In this situation, the Jets are 3.5 point underdogs against the Bills. If Buffalo wins the game by four or more points, a $100 wager on the Bills would come with a payout of $90.91. If New York won the game outright or lost by three points or less, the same $100 wager would net $110 plus the original $100 for a total of $210.

FAQ: Everything you need to know about point spreads

Buffalo Bills Over/Unders aka Bills Totals

Over/under, also called point total, is a wager placed on the combined scoring of a single game. Bookmakers come up with a number and you can either bet the over or — you guessed it — the under. Here’s how it works:

Let's say the Dolphins play the Bills and the over/under is set at 49 points. A wager on the over would require Miami and Buffalo to score 50 total points or more to win. Betting the under is an expectation that the two teams would score 48 or fewer points. It's also possible for the bet to push, which would happen if the game finished with exactly 49 points scored.

In 2020, Buffalo averaged 31.3 points per game (2nd in NFL) and allowed 23.4 points (16th in NFL). The Bills had the league’s fourth-best record when it came to point totals, going 10-5-1 against the over.

FAQ: Betting the point total, explained | What is a push?

Buffalo Bills Moneylines

At 13-3, Buffalo was an excellent play when betting a moneyline as it was tied for the second-best record in the NFL. For odds as straightforward as these, the Bills were one of the more surefire picks last year. Check out this example:

  • Bills -130
  • Patriots +230

The minus (-) and plus (+) signs distinguish the favorite from the underdog, making Buffalo the favorite in this scenario. Odds can be understood more clearly if you think in terms of $10 or $100 increments. A wager on the Bills odds would mean every $130 bet nets $100. And it's the opposite for underdogs: Here the Patriots moneyline was set at +230, meaning a $100 wager would profit $230.

Moneylines are also commonly used when making parlays, which are multiple bets tied into one. Let’s say you bet the Bills moneyline and a -2.5 point spread, Buffalo would need to win by three points or more for that bet to be successful. The risk is greater, but so is the reward with increased odds. Use our Odds Calculator to calculate any bet amount or conversion with confidence, and claim offers like the BetMGM Bonus for immediate value.

FAQ: How to bet on the moneyline | How to make a parlay

Buffalo Bills Props

Player props are wagers on a single player, and they're tied to a single stat found in the box score for a game or even the whole season. These are among the most fun to bet on, especially if you're already playing fantasy football and like the player-specific focus it offers. Check out a hypothetical example below:

  • Josh Allen 2021 passing yards: 4,350.5

FAQ: Here’s how prop betting works

Buffalo Bills Futures

Futures are somewhat similar to prop bets in the way that both are monitored over the course of a season. Except most future bets are focused on end of season success. Examples of futures are:

  • Buffalo Bills odds to win the AFC East
  • Buffalo Bills odds to win the AFC
  • Buffalo Bills odds to win the Super Bowl
  • Josh Allen’s odds to win MVP
  • Stefon Diggs’ odds to win Offensive Player of the Year

If you’re confident that the Bills can win the AFC East or even make a Super Bowl run , this is the place to be. For a full list of NFL futures, click or tap here.

Make sure to check out our sportsbook reviews for more information on what’s available in your state and exclusive sign-up bonuses and promo codes.

Frequently Asked Questions
How do I buy Buffalo Bills tickets?
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When is the Buffalo Bills first game?
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Are the Buffalo Bills on national television this season?
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Have the Buffalo Bills won a championship?
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How old is the Buffalo Bills franchise?
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Next Bills Game

Game Details
@ Tennessee Titans
Tennessee
location pin
Tue 10/1912:15 AM

Titans vs Bills Odds

More Odds
SpreadTotalMoneyline
BUF
Right Arrow-5.5-110
Right Arrowo53.5-110
Right Arrow-250ML
TEN
Right Arrow+5.5-110
Right Arrowu53.5-110
Right Arrow+200ML

Bills Injuries

All NFL Injuries
  • Taiwan Jones

    RB

    Taiwan Jones (hamstring) is questionable this week.

    Questionable

  • Matt Milano

    LB

    Matt Milano (hamstring) is questionable this week.

    Questionable

  • A.J. Epenesa

    DE

    A.J. Epenesa (foot) is questionable this week.

    Questionable

  • Marquez Stevenson

    WR

    Marquez Stevenson (Head) is out this week.

    Out

Buffalo Bills Odds, Bet Types, and Team History

The Buffalo Bills matched a franchise record with 13 wins in 2020. At 13-3, Buffalo won the AFC East for the first time since 1995 and secured the No. 2 seed in the conference. The Bills reached the AFC Championship game before falling to the Kansas City Chiefs. With three playoff appearances in the past four seasons, Buffalo is slowly becoming one of the conference’s more competitive teams.

It should stay that way too now that QB Josh Allen is under contract through 2028. Allen took a major step forward in his third NFL season, earning second-team All-Pro honors after throwing for 4,544 yards and 37 touchdowns with another eight scores on the ground.

Allen’s development played a huge role in Buffalo having the league’s second-best offense, though he also had two All-Pro wideouts to work with. Stefon Diggs cost the Bills four draft picks, including a first rounder, but more than lived up to the billing with a league-best 127 catches for 1,535 yards and eight touchdowns. Cole Beasley did most of his damage in the slot with a career-high 82 receptions for 967 yards and four scores.

Buffalo’s defense finished middle of the pack, allowing 23.4 points per game. All 11 starters from a year ago are back, most notably All-Pro cornerback Tre’Davious White and Pro Bowl linebacker Tremain Edmunds . White broke up 11 passes to go with 1.5 sacks, one interception and two fumble recoveries. Edmunds made 119 total tackles and had two sacks.

The Bills open the 2021 NFL season at home against the Pittsburgh Steelers. You can view the Action Network’s top odds for the game below in addition to an odds comparison for every Week 1 game right here.

Week 6 Odds: Buffalo Bills vs. Tennessee Titans (via BetMGM)

TeamSpreadMoneylineTotal O/U
Buffalo Bills(-5.5)-110-250Over 52.5(-110)
Tennessee Titans(+5.5)+110+200Under 52.5(-110)

More: Matchup Page

Bills Offseason Movement 2021

Trades: none

Draft picks: Gregory Rousseau (EDGE, Miami), Carlos Basham Jr. (EDGE, Wake Forest), Marquez Stevenson (WR, Houston)

Re-signings: Mitch Morse (C, four years), Micah Hyde (S, two years), Jon Feliciano (G, three years), Matt Milano (LB, four years), Daryl Williams (T, three years), Forrest Lamp (G, one year)

Free-agent signings: Emmanuel Sanders (WR, one year), Bobby Hart (T, one year), Matt Breida (RB, one year)

Free-agent losses: Quinton Jefferson (DT, to Raiders)

Bills Rivals

The Bills went 13-3 last year, capturing their first AFC East title since 1995 — a year before Josh Allen was born. Buffalo won all six of its games against division opponents by an average of 13.8 points. Buffalo beat Indianapolis and Baltimore in the postseason before losing to Kansas City in the AFC Championship Game.

The Miami Dolphins finished second in the division at 10-6, though they missed the playoffs in a very competitive AFC. The New England Patriots were third at 7-9 with their fewest wins since 2000. And the New York Jets placed fourth at 2-14, losing 13 straight to open the season before closing it out with wins in two of the last three games.

Find weekly Buffalo Bills odds above. Below you’ll find how to bet on the Bills as well as their complete 2021 schedule, betting trends, performance against-the-spread (ATS), injury history, a fulldepth chart and more.

MORE: Keep up with all Buffalo Bills news

Betting on the Buffalo Bills

Buffalo Bills Point Spreads

Betting point spreads are wagers based on the expectation that a team will win or lose by a certain number of points. The Bills went 13-3 overall but 11-5 against the spread. Buffalo’s 13 wins were by an average of 12.5 points and its three losses were by 12.3 points.

Here’s an example:

  • Jets +3.5 (+110)
  • Bills -3.5 (-110)

In this situation, the Jets are 3.5 point underdogs against the Bills. If Buffalo wins the game by four or more points, a $100 wager on the Bills would come with a payout of $90.91. If New York won the game outright or lost by three points or less, the same $100 wager would net $110 plus the original $100 for a total of $210.

FAQ: Everything you need to know about point spreads

Buffalo Bills Over/Unders aka Bills Totals

Over/under, also called point total, is a wager placed on the combined scoring of a single game. Bookmakers come up with a number and you can either bet the over or — you guessed it — the under. Here’s how it works:

Let's say the Dolphins play the Bills and the over/under is set at 49 points. A wager on the over would require Miami and Buffalo to score 50 total points or more to win. Betting the under is an expectation that the two teams would score 48 or fewer points. It's also possible for the bet to push, which would happen if the game finished with exactly 49 points scored.

In 2020, Buffalo averaged 31.3 points per game (2nd in NFL) and allowed 23.4 points (16th in NFL). The Bills had the league’s fourth-best record when it came to point totals, going 10-5-1 against the over.

FAQ: Betting the point total, explained | What is a push?

Buffalo Bills Moneylines

At 13-3, Buffalo was an excellent play when betting a moneyline as it was tied for the second-best record in the NFL. For odds as straightforward as these, the Bills were one of the more surefire picks last year. Check out this example:

  • Bills -130
  • Patriots +230

The minus (-) and plus (+) signs distinguish the favorite from the underdog, making Buffalo the favorite in this scenario. Odds can be understood more clearly if you think in terms of $10 or $100 increments. A wager on the Bills odds would mean every $130 bet nets $100. And it's the opposite for underdogs: Here the Patriots moneyline was set at +230, meaning a $100 wager would profit $230.

Moneylines are also commonly used when making parlays, which are multiple bets tied into one. Let’s say you bet the Bills moneyline and a -2.5 point spread, Buffalo would need to win by three points or more for that bet to be successful. The risk is greater, but so is the reward with increased odds. Use our Odds Calculator to calculate any bet amount or conversion with confidence, and claim offers like the BetMGM Bonus for immediate value.

FAQ: How to bet on the moneyline | How to make a parlay

Buffalo Bills Props

Player props are wagers on a single player, and they're tied to a single stat found in the box score for a game or even the whole season. These are among the most fun to bet on, especially if you're already playing fantasy football and like the player-specific focus it offers. Check out a hypothetical example below:

  • Josh Allen 2021 passing yards: 4,350.5

FAQ: Here’s how prop betting works

Buffalo Bills Futures

Futures are somewhat similar to prop bets in the way that both are monitored over the course of a season. Except most future bets are focused on end of season success. Examples of futures are:

  • Buffalo Bills odds to win the AFC East
  • Buffalo Bills odds to win the AFC
  • Buffalo Bills odds to win the Super Bowl
  • Josh Allen’s odds to win MVP
  • Stefon Diggs’ odds to win Offensive Player of the Year

If you’re confident that the Bills can win the AFC East or even make a Super Bowl run , this is the place to be. For a full list of NFL futures, click or tap here.

Make sure to check out our sportsbook reviews for more information on what’s available in your state and exclusive sign-up bonuses and promo codes.

Frequently Asked Questions
How do I buy Buffalo Bills tickets?
Right Arrow
When is the Buffalo Bills first game?
Right Arrow
Are the Buffalo Bills on national television this season?
Right Arrow
Have the Buffalo Bills won a championship?
Right Arrow
How old is the Buffalo Bills franchise?
Right Arrow