Eagles vs Rams Predictions, Picks, Odds

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The Rams and Eagles both opened the 2026 season with real Super Bowl aspirations, and Week 4 gives each team a chance to show where it actually stands. The Rams dropped to 1-2 after blowing a 16-point halftime lead in Denver, while the Eagles sit at 2-1 after needing a last-second drive from Jalen Hurts just to beat Tennessee in Week 2. Throw in the fact that Los Angeles will be without its big offseason pass-rush addition, and this NFC matchup is loaded with storylines for Kalshi traders this week.. Before kickoff, be sure to check out this Kalshi promo code.

Let's get into my Rams vs. Eagles prediction and my NFL picks for Week 4. Be sure to download the Action Network app for more picks and analysis.

PREDICTION

Kalshi traders have Los Angeles as the pick to win outright, and that lean lines up with where most sportsbooks have set this game too. The Rams have more juice up front with Matthew Stafford slinging it to Davante Adams and Tyler Higbee, and that passing attack put up 390 yards in Denver even in a loss: all without top receiver Puka Nacua, who was inactive with an injury.

The catch is the Rams will play this one without edge rusher Myles Garrett, who is out roughly 6 weeks after knee surgery, which takes away their best piece on defense. Philadelphia gets a healthier week for Saquon Barkley and Jalen Hurts at home, so the gap between these teams is tighter than the records suggest. That's what makes the winner market worth a look this week: the price hasn't fully caught up to how even this matchup looks on paper.

TOTAL

The total sits at 43.5, and both offenses have shown they can move the ball in bursts. The Rams put up 26 points in Denver, with Stafford already pushing 700-plus yards through three weeks, while the Eagles have leaned on Hurts to grind out two tight, low-scoring wins. Philadelphia's defense is still finding its footing after adding pass rusher Jonathan Greenard this offseason, and the Rams will be without Myles Garrett on the other side. With neither defense fully whole, this total could swing either way, which is exactly why it's worth tracking as a market this week.

My Pick: Rams (Moneyline)

• Rams-Eagles Prediction: Rams (59%), Eagles (41%)
• Rams-Eagles Total: Over/Under 43.5

NFL Week 4 Picks

Week 4 brings a loaded Sunday slate, and Rams vs. Eagles stands out as the headliner with both teams still searching for consistency. Below is a closer look at the pick we like most for this game, along with how to watch and what the weather looks like in Philadelphia.

The clearest trade this week is the Rams covering the spread. Los Angeles still has the deeper group of skill-position talent, and even playing from behind for a half in Denver, and without Puka Nacua, Stafford and the passing game piled up almost 400 yards.

Philadelphia's defense has given up points in bunches already this season, and an offensive line working in a new pass rusher won't be settled by Sunday. Losing Myles Garrett hurts, but it's a bigger problem for L.A.'s defense than for its ability to move the ball and build a lead. That makes the margin market more interesting than the straight win-loss price this week.

Pick: Rams -3.5

Los Angeles Rams vs. Philadelphia Eagles is scheduled for 1:00 p.m. ET on Sunday, October 4, live from Lincoln Financial Field in Philadelphia, Pa. The game is live on FOX.