Sunday’s Top NFL Betting Predictions: Cowboys vs. Patriots, Raiders vs. Broncos Lead Smartest Week 6 Picks

NFL

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Photo by Carmen Mandato/Getty Images. Pictured: Mac Jones #10 of the New England Patriots

PJ Walsh

Updated:

Oct 17, 2021, 02:35 PM EDT

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NFL betting value can come from anywhere, no matter the popularity of the teams.

There really aren't any "small" games when it comes to the pros, but I'm not breaking news by saying that Sunday's Cowboys vs. Patriots matchup will be much more interesting to casual bettors than Dolphins vs. Jaguars in London.

Now, that doesn't necessarily mean that Cowboys vs. Patriots is better or worse than Dolphins vs. Jaguars, just different in terms of how they're viewed by fans and bettors.

From strictly a value standpoint the popularity of a game doesn't affect how smart of a bet it is either, with some of the lower-profile matchups also doubling as the best betting opportunities.

However, when it comes to Sunday's NFL Week 6 slate, the games with the most interesting storylines are showing as the smartest bets as well, including Packers vs. Bears, Vikings vs. Panthers, Raiders vs. Broncos and the aforementioned Cowboys vs. Patriots.

Without further ado, let's dive right into the best ways to bet these four NFL Week 6 matchups.