Matthew Stafford's back injury has been one of the big stories of the NFL offseason.
Los Angeles' quarterback is dealing with an aggravated disc that kept him sidelined for most of the summer.
However, Stafford was able to return to practice and is expected to start Sunday's game against the Houston Texans.
With Stafford seemingly good to go, NFL odds for Texans vs. Rams (4:25 p.m. ET, CBS) have settled in at Los Angeles -3, with the over/under listed at 43.5.
Interestingly, even with potential injury uncertainty, this game is still offering Action PRO's single-largest spread or over/under edge for the entire NFL Week 1 slate.
Here's the spread prediction popping with value for Texans vs. Rams on Sunday afternoon.
NFL Odds, Texans vs. Rams Spread Prediction
*Odds as of Sunday morning
Los Angeles is a 3-point spread favorite against Houston as of the time of writing.