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NFL Predictions Week 4: Expert Data-Driven Picks for Sunday, Oct. 4

NFL Predictions Week 4: Expert Data-Driven Picks for Sunday, Oct. 4 article feature image
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Sep 27, 2026; Orchard Park, New York, USA; Buffalo Bills running back James Cook III (4) looks on during warm ups prior the game against the Los Angeles Chargers at New Highmark Stadium. Mandatory Credit: Gregory Fisher-Imagn Images

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Action Network's Predictive Analytics team crunched the numbers and came up with four NFL predictions for Week 4 of the 2026 season.

The data-driven NFL picks for Week 4 include games featuring Colts vs Commanders, Patriots vs Bills, Dolphins vs Vikings, Lions vs Panthers and more.


NFL Week 4