Thursday Night Football for NFL Week 12 features a matchup between the Buffalo Bills and Houston Texans at NRG Stadium in Houston, Texas. This Thursday Night Football game will broadcast live on Prime Video at 8:15 p.m. ET.
- For more Thursday Night Football coverage, check out our Texans vs Bills preview, which includes five picks for TNF.
Continue below for Thursday Night Football odds and my Texans vs Bills parlay, which includes picks for the Bills moneyline and a James Cook prop.
Texans vs Bills Parlay
- Bills Moneyline (-270)
- James Cook Under 2.5 Receptions (-153)
Parlay Odds: +116 (DraftKings)
Texans vs Bills Odds
| Bills Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-5.5 -120 | 43.5 -108o / -112u | -270 |
| Texans Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+5.5 +100 | 43.5 -108o / -112u | +225 |
- Texans vs Bills Moneyline: Texans +225, Bills -270
- Texans vs Bills Over/Under: 43.5 (-108o / -112u)
- Texans vs Bills Spread: Texans +5.5 (+100), Bills -5.5 (-120)
Texans vs Bills Preview, Parlay Picks
Bills Moneyline (-270)

The Texans will attempt to pull off the upset at home in the absence of their starting quarterback, C.J. Stroud. Houston is actually 2-0 with backup Davis Mills under center, but I expect the offense so sputter tonight.
Mills and the Texans were held to 16 points on Sunday against the lowly Titans, and while Houston has been outstanding on defense, I do not think the unit will get enough stops against Josh Allen and the Bills.
According to our Evan Abrams, Allen is 8-2 straight up in his career when facing a defense that allows under 20 points per game (such as the Texans). His only two losses came against Patrick Mahomes and Tom Brady.
James Cook Under 2.5 Receptions (-153)

We will team up with our Action PRO report for this prop.
The Bills have mixed in running back Ty Johnson in passing situations this season. Additionally, the game script will bode well for this James Cook receptions under, as I expect the Bills to run the ball heavily in the second half while playing with the lead (they are 5.5-to-6-point favorites on the spread).
Cook has cashed this prop in four of his last six games, and our Action PRO report projects 1.9 receptions tonight.
Texans vs Bills Parlay
- Bills Moneyline (-270)
- James Cook Under 2.5 Receptions (-153)
Parlay Odds: +116 (DraftKings)



















