Roma vs Lazio Odds & Live Scores - September 21, 2025 | The Action Network

Roma at Lazio

10:30 am

Roma

5-0-2

1

1 - 0

Lazio

5-0-1

0

MatchupOpenSpreadTotalMoneyline
Roma 5-0-2	-1	-0.5+160	o2.5+125	+180
Lazio 5-0-1	u2.5	+0.5-235	u2.5-164	+180

location pin

Sunday 10:30 a.m.

September 21, 2025

Stadio OlimpicoRome

ROM PK-122

1u

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Serie A Public Betting

Lazio are 4-0 in their last 5 games.
Lazio are 5-0 in their last 5 games against the spread
Lazio are 3-0 in their road games against the spread
The totals have gone OVER in 3 of Lazio' last 5 games
The totals have gone OVER in 2 of Lazio' 3 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Lazio	6-0	3-0	3-0	4-0	2-0
Roma	0-2	0-1	0-1	0-1	0-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Lazio	3-3	2-1	1-2	2-2	1-1
Roma	1-1	1-0	0-1	0-1	1-0

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Lazio	5-0	2-0-1	3-0	4-0	1-0-1
Roma	0-1	0-1	0-0-1	0-0-1	0-1

date	opponent	score	spread	over/under	moneyline
Sep 14th	@SAS	L 0-1	-0.5 L	U 2.5	SAS -112
Aug 31st	VER	W 4-0	-1 W	O 2.5	-
Aug 24th	@COM	L 0-2	+0.5 L	U 2.5	COM +210
May 25th	LEC	L 0-1	-1.5 L	U 2.5	LEC -227
May 18th	@INT	L 2-2	+1 W	O 2.5	INT +392

Danilho Doekhi
DEF
Doekhi is injured
Out Indefinitely
Gustav Isaksen
F
Isaksen is injured with groin
Out Indefinitely

Lorenzo Pellegrini
MID
Pellegrini is out with thigh
Out
Leonardo Balerdi
DEF
Leonardo Balerdi is expected to return Early July 2026 from Calf injury.
Out

Rodrigo Mora
MID
Mora is doubtful with thigh
Doubtful
Wesley Franca
DEF
Franca is out with groin
Out

See more SERIEA Injuries

Roma

Lazio

22

Fouls

14

11

Shots

11

6

Corners

3

4

Offsides

0

0

Red Cards

2

1

Yellow Cards

1

6

Shots On Goal

3

51%

Possession Time

49%

Roma

Goalkeeping

Lazio

Could not load odds

See more Serie A Odds

MatchupOverUnder
Roma 5-0-2	N/A	N/A
Lazio 5-0-1	N/A	N/A