Roma vs. Lazio Odds & Betting Predictions - September 21, 2025

Roma at Lazio

10:30 am

Roma

3-1

1

1 - 0

Lazio

1-3

0

MatchupOpenSpreadTotalMoneyline
Roma 3-1	-1	-0.5+160	o2.5+125	N/A
Lazio 1-3	u2.5	+0.5-235	u2.5-164	N/A

location pin

Sunday 10:30 a.m.

September 21, 2025

Stadio OlimpicoRoma

Serie A Public Betting

Lazio are 1-3 in their last 5 games.
Lazio are 1-3 in their last 5 games against the spread
Lazio are 0-2 in their road games against the spread
The totals have gone OVER in 1 of Lazio' last 4 games
The totals have gone OVER in 1 of Lazio' 2 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Lazio	1-3	1-1	0-2	1-1	0-2
Roma	3-1	1-1	2-0	3-1	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Lazio	1-3	1-1	0-2	1-1	0-2
Roma	0-4	0-2	0-2	0-4	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Lazio	1-3	1-1	0-2	1-1	0-2
Roma	3-1	1-1	2-0	3-1	N/A

date	opponent	score	spread	over/under	moneyline
Sep 14th	@SAS	L 0-1	-0.5 L	U 2.5	SAS -112
Aug 31st	VER	W 4-0	-1 W	O 2.5	-
Aug 24th	@COM	L 0-2	+0.5 L	U 2.5	COM +210
May 25th	LEC	L 0-1	-1.5 L	U 2.5	LEC -227
May 18th	@INT	L 2-2	+1 W	O 2.5	INT +392

Pedro
F
Shoulder Injury
Out Indefinitely
Matteo Guendouzi
MID
Ankle/Foot Injury
Out Indefinitely

Matias Vecino
MID
Vecino is doubtful with muscle
Doubtful
Samuel Gigot
DEF
Ankle/Foot Injury
Out
Toma Basic
MID
Thigh Muscle Strain
Out
Taty Castellanos
F
Suspended
Out
Manuel Lazzari
MID
Lazzari is out with muscle
Out

See more SERIEA Injuries

Roma

Lazio

22

Fouls

14

11

Shots

11

6

Corners

3

4

Offsides

0

0

Red Cards

2

1

Yellow Cards

1

6

Shots On Goal

3

51%

Possession Time

49%

Roma

Goalkeeping

Lazio

Could not load odds

See more Serie A Odds

MatchupOverUnder
Roma 3-1	o1.5+175	u1.5-250
Lazio 1-3	o1.5+175	u1.5-250