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Barcelona vs Slavia Praha Prediction, Pick, Champions League Odds for Wednesday, January 21

Barcelona vs Slavia Praha Prediction, Pick, Champions League Odds for Wednesday, January 21 article feature image
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Barcelona (3-2-1) and Slavia Praha (0-3-3) will face off today at 3:00 p.m. EST at Fortuna Arena in Prague.

Barcelona is favored at a -300 price, with the over/under set at 3.5 (-110o / -116u) goals.

Let's get into my Barcelona vs. Slavia Praha prediction.

Barcelona vs. Slavia Praha Prediction

Pick: Barcelona to Win to Nil
My Barcelona vs. Slavia Praha best bet is on Barcelona to win the match without conceding a goal.

Barcelona vs. Slavia Praha Odds

Barcelona Logo
Wednesday, January 21, 2026
3:00 p.m. EST
-
Slavia Praha Logo
Barcelona Odds
SpreadTotalMoneyline
-1.5
-130
3.5
-110o / -116u
-300
Slavia Praha Odds
SpreadTotalMoneyline
+1.5
-110
3.5
-110o / -116u
+650
Odds via DraftKings. Get up-to-the-minute SOCCER odds here.
DraftKings Logo

Barcelona vs. Slavia Praha Picks, Parlay

Pick:Barcelona to Win to Nil
This Slavia Praha vs. Barcelona pick centers on the home side’s complete inability to generate offense. Slavia Praha has scored just twice in the entire Champions League league phase, the lowest total of any team in the competition. Their attacking metrics are just as alarming, having underperformed their non-penalty expected goals (xG) by 4.59, the worst mark in the tournament. They also rank last for big chances created.

Even a porous Barcelona defense should be able to handle an attack this limited. While it’s true that Barcelona have conceded in each of their last nine Champions League matches, the level of opposition in those games was far higher than what Slavia Praha offers. The Czech side has also been out of competitive action for more than a month due to their domestic winter break, which is far from ideal preparation. In a home fixture earlier in the competition against Athletic Bilbao, Slavia produced just 0.5 xG and failed to score.

Barcelona, meanwhile, comes into this match needing a result. Currently sitting 15th in the standings, Hansi Flick’s side is two points outside the top eight positions that guarantee direct qualification to the Round of 16. Following a disappointing league defeat to Real Sociedad, expect a focused response. With an attack averaging 2.3 goals per game in European competition, Barcelona has more than enough quality to secure a comfortable win and a much-needed clean sheet.
Playbook

Barcelona vs. Slavia Praha Projections

Projected Chance of Winning

BarcelonaDrawSlavia Praha
72.8%14.9%12.2%

Projected Total Goals

BarcelonaTotal GoalsSlavia Praha
2.543.450.91

Barcelona vs. Slavia Praha Betting Analysis

This matchup is a classic case of a motivated giant facing a team that is already virtually eliminated. Barcelona enters the contest looking to bounce back from a domestic defeat and improve its position in the Champions League standings. Slavia Praha, meanwhile, sit 33rd in the table with little left to play for beyond pride.

The hosts have been thoroughly outmatched in this competition. When priced as heavy underdogs (at odds of +400 or greater), they have lost all three such matches by a 3-0 scoreline, highlighting how much they struggle against elite opposition. Their recent lack of competitive action only compounds the difficulty of this challenge.

History also leans heavily in Barcelona’s favor. The Catalans are unbeaten in their last eight meetings with Czech opposition, winning seven of them. The most recent encounters between these sides came in the 2019-20 season, when Barcelona won 2-1 in Praha before settling for a 0-0 draw at home. Even without the suspended Lamine Yamal, Barcelona’s attacking depth should be more than sufficient against a Slavia side that has failed to win any of its last 17 Champions League matches.

Check out the best soccer odds before making your Slavia Praha vs Barcelona picks.

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