| Steve Mounie | F | Out | Heel Injury | Heel Injury | Nov 6 |
| Marius Wolf | MID | Out | Marius Wolf is expected to return Late September 2025 from Knee injury. | Wolf is out with knee | Sep 3 |
| Keven Schlotterbeck | DEF | Out | Keven Schlotterbeck is expected to return Late September 2025 from Muscle injury. | Schlotterbeck is out with muscle | Sep 10 |
| Maximilian Bauer | DEF | Out indefinitely | Bauer, Maximilian: missing - injured | Bauer is injured | Aug 23 |
| Mert Komur | MID | Out | Mert Komur is expected to return Late October 2025 from Broken toe. | Komur is out with toe | Sep 2 |
| Niklas Lomb | GK | Out indefinitely | Virus | Virus | Jan 24 |
| Jonas Hofmann | MID | Out | Jonas Hofmann is expected to return Late September 2025 from Muscle injury. | Hofmann is out with muscle | Sep 6 |
| Patrik Schick | F | Out indefinitely | Groin Strain | Groin Strain | Mar 27 |
| Mark Flekken | GK | Out indefinitely | Virus | Virus | Jan 24 |
| Janis Blaswich | GK | Out indefinitely | Knock | Knock | Jul 11 |
| Edmond Tapsoba | DEF | Out indefinitely | None | Tapsoba is injured | Mar 27 |
| Loic Bade | DEF | Out indefinitely | Hamstring | Hamstring | Feb 25 |
| Alejo Sarco | F | Out indefinitely | None | Sarco is injured | May 10 |
| Marvin Friedrich | DEF | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Aug 15 |
| Nico Elvedi | DEF | Out indefinitely | Illness | Illness | Nov 11 |
| Franck Honorat | MID | Doubtful | None | Honorat is doubtful | Jul 12 |
| Jonas Omlin | GK | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Mar 18 |
| Joe Scally | DEF | Out indefinitely | Virus | Virus | Jan 17 |
| Gio Reyna | MID | Out indefinitely | Illness | Illness | Apr 10 |
| Tim Kleindienst | F | Out | Tim Kleindienst is expected to return Mid September 2025 from Meniscus injury. | Kleindienst is out with knee | Sep 1 |
| Niklas Swider | MID | Out | Niklas Swider is expected to return Early October 2025 from Mononucleosis. | Swider is out with illness | Sep 10 |
| L. Klünter | DEF | Out indefinitely | Shoulder Injury | Shoulder Injury | May 2 |
| S. Kapino | GK | Out | Hip/Thigh Injury | Hip/Thigh Injury | Feb 8 |
| N. De Medina | DEF | Out indefinitely | Illness | Illness | Feb 7 |
| J. Laursen | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 19 |
| S. Vasiliadis | MID | Out indefinitely | Knee Injury | Knee Injury | Apr 18 |
| B. Lasme | A | Out indefinitely | Knee Injury | Knee Injury | Jul 11 |
| F. Krüger | A | Out indefinitely | Illness | Illness | Dec 6 |
| Michy Batshuayi | F | Out indefinitely | Hamstring | Hamstring | Nov 23 |
| Mario Gotze | MID | Out indefinitely | None | Gotze is injured | Apr 19 |
| Timothy Chandler | MID | Out indefinitely | None | Chandler is injured | Feb 28 |
| Michael Zetterer | GK | Out | Arm/Elbow injury | Arm/Elbow injury | Apr 4 |
| Ellyes Skhiri | MID | Out indefinitely | Knock | Knock | Jan 17 |
| Aurelio Buta | DEF | Out indefinitely | Knee Injury | Knee Injury | Jan 23 |
| Eric Ebimbe | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Mar 21 |
| Ritsu Doan | MID | Out indefinitely | Eye Injury | Eye Injury | Jan 17 |
| Jessic Ngankam | F | Out indefinitely | Ngankam, Jessic: missing - injured | Ngankam is injured | Aug 23 |
| Marvin Pieringer | F | Out | Marvin Pieringer is expected to return Mid September 2025 from Ankle injury. | Pieringer is out with ankle | Sep 1 |
| Frank Feller | GK | Out indefinitely | Feller, Frank: missing - injured | Feller is injured | Aug 23 |
| Nick Rothweiler | MID | Out | Nick Rothweiler is expected to return Late September 2025 from Muscle injury. | Rothweiler is out with muscle | Sep 3 |
| Paulo Otávio | DEF | Out indefinitely | Knee Injury | Knee Injury | Aug 8 |
| Andreas Poulsen | DEF | Out | Shoulder Injury | Shoulder Injury | Oct 31 |
| Dominique Heintz | DEF | Day to day | Dominique Heintz is expected to return in A few days from Illness. | Heintz is day-to-day with illness | Sep 3 |
| Marvin Schwabe | GK | Out indefinitely | Virus | Virus | Feb 28 |
| Luca Kilian | DEF | Out | Luca Kilian is expected to return Late May 2026 from Cruciate ligament injury. | Kilian is out with knee | Sep 9 |
| Fayssal Harchaoui | MID | Out | Harchaoui, Fayssal: missing - other | Harchaoui is out | Aug 23 |
| Malek El Mala | DEF | Out | El Mala, Malek: missing - other | El Mala is out | Aug 23 |
| Danny Blum | A | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 11 |
| J. Horn | DEF | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Sep 5 |
| C. Schindler | DEF | Out | Illness | Illness | Mar 30 |
| L. Tempelmann | MID | Out indefinitely | Ankle Ligaments | Ankle Ligaments | Apr 4 |
| F. Hübner | DEF | Out indefinitely | Knock | Knock | Nov 4 |
| T. Usami | MID | Out | Knee Injury | Knee Injury | Apr 25 |
| A. Morales | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | May 18 |
| Thomas Pledl | MID | Out indefinitely | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Dec 15 |
| Leonardo Pablo Koutris | DEF | Out | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Oct 27 |
| F. Klaus | MID | Out | Suspended | Suspended | May 30 |
| Daniel Ginczek | A | Out indefinitely | Virus | Virus | Jan 24 |
| Benito Raman | A | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | May 8 |
| Róbert Boženík | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 25 |
| M. Christiansen | MID | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | May 9 |
| J. Willems | DEF | Out | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Dec 16 |
| J. Hoogma | DEF | Out indefinitely | Virus | Virus | Jan 24 |
| R. Ache | A | Out indefinitely | Thigh Muscle Rupture | Thigh Muscle Rupture | Feb 26 |
| Yussuf Poulsen | F | Out indefinitely | Illness | Illness | Oct 5 |
| Hannes Hermann | GK | Out | Hannes Hermann is expected to return Late September 2025 from Ankle injury. | Hermann is out with ankle | Aug 26 |
| Håvard Kallevik Nielsen | A | Out indefinitely | Knock | Knock | Jul 4 |
| Nicolai Müller | MID | Out indefinitely | Knee Injury | Knee Injury | Oct 14 |
| Pirmin Schwegler | MID | Out | Hip/Thigh Injury | Hip/Thigh Injury | Mar 29 |
| D. Aogo | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Apr 13 |
| P. Twumasi | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Oct 7 |
| Josip Elez | DEF | Out | Knock | Knock | Mar 17 |
| Jonathas | A | Out | Suspended | Suspended | May 11 |
| Salif Sané | DEF | Out | Suspended | Suspended | May 8 |
| Florian Niederlechner | F | Out indefinitely | Knock | Knock | Jan 30 |
| Peter Pekarik | DEF | Out indefinitely | Virus | Virus | Jan 24 |
| Filip Uremovic | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Oct 29 |
| Wilfried Kanga | F | Out indefinitely | Toe Injury | Toe Injury | Mar 13 |
| Deyovaisio Zeefuik | DEF | Out indefinitely | Groin Strain | Groin Strain | Oct 25 |
| Agustin Rogel | DEF | Out indefinitely | Knee Injury | Knee Injury | Feb 20 |
| Andrej Kramaric | F | Out indefinitely | Virus | Virus | Feb 21 |
| Mergim Berisha | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Jan 20 |
| Vladimir Coufal | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| Adam Hlozek | F | Out indefinitely | Hlozek, Adam: missing - injured | Hlozek is injured | Aug 23 |
| Grischa Promel | MID | Out indefinitely | None | Promel is injured | Apr 25 |
| Stanley Nsoki | DEF | Doubtful | Nsoki, Stanley: doubtful - injured | Nsoki is doubtful | Aug 23 |
| Wouter Burger | MID | Out | Wouter Burger is expected to return Late September 2025 from Ankle injury. | Burger is out with ankle | Aug 26 |
| Anthony Caci | DEF | Out | Gluteal Strain | Gluteal Strain | Feb 29 |
| Robin Zentner | GK | Out | Robin Zentner is expected to return Early October 2025 from Back injury. | Zentner is out with back | Sep 9 |
| Lee Jae-sung | MID | Out | Jae-Sung Lee is expected to return Early October 2025 from Hamstring Injury. | Jae-sung is out with hamstring | Sep 8 |
| Niklas Tauer | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Feb 6 |
| Benedict Hollerbach | F | Out | Benedict Hollerbach is expected to return Late September 2025 from Hamstring Injury. | Hollerbach is out with hamstring | Aug 26 |
| Maxim Dal | DEF | Out indefinitely | Dal, Maxim: missing - injured | Dal is injured | Aug 23 |
| Daniel Gleiber | MID | Out | Daniel Gleiber is expected to return Late September 2025 from Hip injury. | Gleiber is out with hip | Aug 30 |
| Benjamin Henrichs | DEF | Out indefinitely | None | Henrichs is injured | Jan 11 |
| Timo Werner | F | Out indefinitely | None | Werner is injured | May 15 |
| Eljif Elmas | MID | Out indefinitely | None | Elmas is injured | Jan 1 |
| Assan Ouedraogo | MID | Out indefinitely | None | Ouedraogo is injured | Nov 29 |
| Tidiam Gomis | F | Out indefinitely | Gomis, Tidiam: missing - injured | Gomis is injured | Aug 22 |
| Ezechiel Banzuzi | MID | Out | Ezechiel Banzuzi is expected to return Early October 2025 from Broken wrist. | Banzuzi is out with wrist | Sep 9 |
| M. Terrazzino | A | Out | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Oct 4 |
| C. Okoroji | DEF | Out indefinitely | Thigh Muscle Rupture | Thigh Muscle Rupture | Jun 17 |
| M. Ritter | A | Out | Back Injury | Back Injury | Nov 30 |
| S. Mamba | A | Out | Suspended | Suspended | Jun 13 |
| Paul Seguin | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | May 9 |
| Timo Baumgartl | DEF | Out indefinitely | Testicular Cancer | Testicular Cancer | Sep 8 |
| Thomas Ouwejan | DEF | Out indefinitely | Groin Strain | Groin Strain | Mar 13 |
| Ibrahima Cisse | DEF | Out indefinitely | Knock | Knock | Feb 6 |
| Leo Greiml | DEF | Out indefinitely | Knock | Knock | Jan 23 |
| Abdoulie Ceesay | F | Out | Abdoulie Ceesay is expected to return Late September 2025 from Ankle injury. | Ceesay is out with ankle | Aug 26 |
| Ricky Jade-Jones | MID | Out indefinitely | Jade-Jones, Ricky: missing - injured | Jade-Jones is injured | Aug 23 |
| Oussama Haddadi | DEF | Out | Suspended | Suspended | Dec 20 |
| Oliver Burke | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jun 7 |
| Danilho Doekhi | DEF | Out indefinitely | None | Doekhi is injured | Oct 27 |
| Alex Kral | MID | Out indefinitely | Back Injury | Back Injury | Jan 30 |
| Andras Schafer | MID | Out indefinitely | Foot Injury | Foot Injury | Apr 11 |
| Andrik Markgraf | DEF | Out | Andrik Markgraf is expected to return Mid September 2025 from Unknown. | Markgraf is out with unknown | Aug 26 |
| Niklas Stark | DEF | Out | Niklas Stark is expected to return in About a week from Physical discomfort. | Stark is out with soreness | Sep 4 |
| Mitchell Weiser | DEF | Out indefinitely | Weiser, Mitchell: missing - injured | Weiser is injured | Aug 23 |
| Marco Friedl | DEF | Out | Marco Friedl is expected to return Late September 2025 from Medial collateral ligament injury. | Friedl is out with knee | Sep 9 |
| Amos Pieper | DEF | Out indefinitely | Pieper, Amos: missing - injured | Pieper is injured | Aug 23 |
| Olivier Deman | MID | Out | Olivier Deman is expected to return Late December 2025 from Broken ankle. | Deman is out with ankle | Aug 26 |
| Julian Malatini | DEF | Out | Julian Malatini is expected to return Late September 2025 from Ankle injury. | Malatini is out with ankle | Aug 26 |
| Lovro Majer | MID | Out | Nose Injury | Nose Injury | Aug 24 |
| Kevin Paredes | MID | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Jan 23 |
| Moritz Jenz | DEF | Out indefinitely | Knock | Knock | Apr 11 |
| Dzenan Pejcinovic | F | Out indefinitely | None | Pejcinovic is injured | May 17 |
| Nicolas Cozza | DEF | Out indefinitely | None | Cozza is injured | Sep 14 |
| Denis Vavro | DEF | Out | Denis Vavro is expected to return Mid December 2025 from Groin injury. | Vavro is out with groin | Aug 26 |
FC Ingolstadt 04
FC Nürnberg
Fortuna Düsseldorf
Greuther Furth
Hannover 96
Hertha BSC
SC Paderborn 07
Schalke 04
Tunisia
