| Jeffrey Gouweleeuw | DEF | Out | Jeffrey Gouweleeuw is expected to return Mid November 2025 from Medial collateral ligament injury. | Gouweleeuw is out with knee | Oct 28 |
| Steve Mounie | F | Out | Heel Injury | Heel Injury | Nov 6 |
| Niklas Lomb | GK | Out indefinitely | Virus | Virus | Jan 24 |
| Patrik Schick | F | Out indefinitely | Groin Strain | Groin Strain | Mar 27 |
| Mark Flekken | GK | Out indefinitely | Virus | Virus | Jan 24 |
| Janis Blaswich | GK | Out indefinitely | Knock | Knock | Jul 11 |
| Robert Andrich | MID | Suspended | Robert Andrich is serving a suspension for Red card. | Andrich is suspended with red card | Oct 29 |
| Exequiel Palacios | MID | Out | Exequiel Palacios is expected to return Mid January 2026 from Groin injury. | Palacios is out with groin | Sep 13 |
| Edmond Tapsoba | DEF | Out indefinitely | None | Tapsoba is injured | Mar 27 |
| Loic Bade | DEF | Out indefinitely | Hamstring | Hamstring | Feb 25 |
| Noah Mbamba | MID | Out | Noah Mbamba is expected to return Mid October 2025 from Unknown. | Mbamba is out with unknown | Sep 27 |
| Malik Tillman | MID | Out | Malik Tillman is expected to return in About a week from Thigh injury. | Tillman is out with thigh | Oct 29 |
| Harry Kane | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | May 3 |
| Manuel Neuer | GK | Out indefinitely | Broken Leg | Broken Leg | Apr 11 |
| Joshua Kimmich | DEF | Out | Suspended | Suspended | Feb 16 |
| Raphael Guerreiro | DEF | Out indefinitely | Knock | Knock | Nov 5 |
| Alphonso Davies | MID | Out | Alphonso Davies is expected to return Early December 2025 from Cruciate ligament injury. | Davies is out with knee | Aug 26 |
| Joao Palhinha | MID | Out | Suspended | Suspended | Mar 12 |
| Luis Diaz | F | Out | Knee Injury | Knee Injury | Apr 11 |
| Hiroki Ito | DEF | Out | Hiroki Ito is expected to return Mid December 2025 from Metatarsal fracture. | Ito is out with foot | Oct 23 |
| Jamal Musiala | MID | Out indefinitely | Hamstring | Hamstring | Apr 3 |
| Nicolas Jackson | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Mar 7 |
| Tarek Buchmann | DEF | Out | Tarek Buchmann is expected to return Early October 2025 from Foot injury. | Buchmann is out with foot | Sep 11 |
| Emre Can | MID | Out indefinitely | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Feb 14 |
| Niklas Sule | DEF | Out | Niklas Süle is expected to return Late November 2025 from Toe injury. | Sule is out with toe | Oct 30 |
| Karim Adeyemi | MID | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Apr 3 |
| Diant Ramaj | GK | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Feb 26 |
| Felix Nmecha | MID | Out indefinitely | None | Nmecha is injured | Feb 28 |
| Julian Ryerson | DEF | Doubtful | Ryerson, Julian: doubtful - injured | Ryerson is doubtful | Aug 23 |
| Julien Duranville | F | Out indefinitely | Duranville, Julien: missing - injured | Duranville is injured | Aug 23 |
| Fabio Silva | F | Out | Fábio Silva is expected to return Mid September 2025 from Knock injury. | Silva is out with maintenance | Aug 26 |
| Maximilian Beier | F | Out indefinitely | None | Beier is injured | May 16 |
| Daniel Svensson | DEF | Out indefinitely | None | Svensson is injured | Mar 7 |
| Marvin Friedrich | DEF | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Aug 15 |
| Nico Elvedi | DEF | Out indefinitely | Illness | Illness | Nov 11 |
| Franck Honorat | MID | Doubtful | None | Honorat is doubtful | Jul 12 |
| Jonas Omlin | GK | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Mar 18 |
| Joe Scally | DEF | Out indefinitely | Virus | Virus | Jan 17 |
| Gio Reyna | MID | Out indefinitely | Illness | Illness | Apr 10 |
| Fabio Chiarodia | DEF | Out | Fabio Chiarodia is expected to return Late November 2025 from Hip injury. | Chiarodia is out with hip | Oct 29 |
| Robin Hack | MID | Out | Robin Hack is expected to return Mid December 2025 from Meniscus injury. | Hack is out with knee | Sep 19 |
| Tim Kleindienst | F | Out | Tim Kleindienst is expected to return Late November 2025 from Meniscus injury. | Kleindienst is out with knee | Oct 21 |
| Jens Castrop | MID | Suspended | Jens Castrop is serving a suspension for Red card. | Castrop is suspended with red card | Oct 25 |
| L. Klünter | DEF | Out indefinitely | Shoulder Injury | Shoulder Injury | May 2 |
| S. Kapino | GK | Out | Hip/Thigh Injury | Hip/Thigh Injury | Feb 8 |
| N. De Medina | DEF | Out indefinitely | Illness | Illness | Feb 7 |
| J. Laursen | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 19 |
| S. Vasiliadis | MID | Out indefinitely | Knee Injury | Knee Injury | Apr 18 |
| B. Lasme | A | Out indefinitely | Knee Injury | Knee Injury | Jul 11 |
| F. Krüger | A | Out indefinitely | Illness | Illness | Dec 6 |
| Michy Batshuayi | F | Out indefinitely | Hamstring | Hamstring | Nov 23 |
| Mario Gotze | MID | Out indefinitely | None | Gotze is injured | Apr 19 |
| Mahmoud Dahoud | MID | Out indefinitely | Shoulder Injury | Shoulder Injury | Jan 12 |
| Timothy Chandler | MID | Out indefinitely | None | Chandler is injured | Feb 28 |
| Michael Zetterer | GK | Out | Arm/Elbow injury | Arm/Elbow injury | Apr 4 |
| Ellyes Skhiri | MID | Out indefinitely | Knock | Knock | Jan 17 |
| Aurelio Buta | DEF | Out indefinitely | Knee Injury | Knee Injury | Jan 23 |
| Ritsu Doan | MID | Out indefinitely | Eye Injury | Eye Injury | Jan 17 |
| Hrvoje Smolcic | DEF | Out | Hrvoje Smolcic is expected to return Mid October 2025 from Muscle injury. | Smolcic is out with muscle | Oct 2 |
| Oscar Hojlund | MID | Out | Oscar Höjlund is expected to return Mid November 2025 from Thigh injury. | Hojlund is out with thigh | Oct 21 |
| Leart Paqarada | DEF | Out | Leart Paqarada is expected to return Late May 2026 from Cruciate ligament injury. | Paqarada is out with knee | Sep 15 |
| Mikkel Kaufmann | F | Out | Mikkel Kaufmann is expected to return Mid November 2025 from Groin injury. | Kaufmann is out with groin | Oct 18 |
| Frank Feller | GK | Out indefinitely | Feller, Frank: missing - injured | Feller is injured | Aug 23 |
| Sirlord Conteh | F | Out | Sirlord Conteh is expected to return Late December 2025 from Meniscus injury. | Conteh is out with knee | Oct 20 |
| Paulo Otávio | DEF | Out indefinitely | Knee Injury | Knee Injury | Aug 8 |
| Andreas Poulsen | DEF | Out | Shoulder Injury | Shoulder Injury | Oct 31 |
| Luca Kilian | DEF | Out | Luca Kilian is expected to return Late May 2026 from Cruciate ligament injury. | Kilian is out with knee | Sep 9 |
| Timo Hubers | DEF | Out for season | Timo Hübers is Out for season with Knee surgery. | Hubers is out for season with knee | Oct 26 |
| Jan Thielmann | MID | Out | Jan Thielmann is expected to return Late November 2025 from Hamstring Injury. | Thielmann is out with hamstring | Oct 24 |
| Rav Van den Berg | DEF | Out | Rav van den Berg is expected to return Late November 2025 from Shoulder injury. | Van den Berg is out with shoulder | Oct 21 |
| Danny Blum | A | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 11 |
| J. Horn | DEF | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Sep 5 |
| C. Schindler | DEF | Out | Illness | Illness | Mar 30 |
| L. Tempelmann | MID | Out indefinitely | Ankle Ligaments | Ankle Ligaments | Apr 4 |
| F. Hübner | DEF | Out indefinitely | Knock | Knock | Nov 4 |
| T. Usami | MID | Out | Knee Injury | Knee Injury | Apr 25 |
| A. Morales | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | May 18 |
| Thomas Pledl | MID | Out indefinitely | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Dec 15 |
| Leonardo Pablo Koutris | DEF | Out | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Oct 27 |
| F. Klaus | MID | Out | Suspended | Suspended | May 30 |
| Daniel Ginczek | A | Out indefinitely | Virus | Virus | Jan 24 |
| Benito Raman | A | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | May 8 |
| Róbert Boženík | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 25 |
| M. Christiansen | MID | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | May 9 |
| J. Willems | DEF | Out | ACL Knee Ligament Injury | ACL Knee Ligament Injury | Dec 16 |
| J. Hoogma | DEF | Out indefinitely | Virus | Virus | Jan 24 |
| R. Ache | A | Out indefinitely | Thigh Muscle Rupture | Thigh Muscle Rupture | Feb 26 |
| Yussuf Poulsen | F | Out indefinitely | Illness | Illness | Oct 5 |
| Fabio Balde | F | Out | Fabio Balde is expected to return Mid November 2025 from Muscle injury. | Balde is out with muscle | Oct 29 |
| Hannes Hermann | GK | Out | Hannes Hermann is expected to return Early November 2025 from Ankle injury. | Hermann is out with ankle | Oct 20 |
| Håvard Kallevik Nielsen | A | Out indefinitely | Knock | Knock | Jul 4 |
| Nicolai Müller | MID | Out indefinitely | Knee Injury | Knee Injury | Oct 14 |
| Pirmin Schwegler | MID | Out | Hip/Thigh Injury | Hip/Thigh Injury | Mar 29 |
| D. Aogo | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Apr 13 |
| P. Twumasi | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Oct 7 |
| Josip Elez | DEF | Out | Knock | Knock | Mar 17 |
| Jonathas | A | Out | Suspended | Suspended | May 11 |
| Salif Sané | DEF | Out | Suspended | Suspended | May 8 |
| Florian Niederlechner | F | Out indefinitely | Knock | Knock | Jan 30 |
| Peter Pekarik | DEF | Out indefinitely | Virus | Virus | Jan 24 |
| Filip Uremovic | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Oct 29 |
| Wilfried Kanga | F | Out indefinitely | Toe Injury | Toe Injury | Mar 13 |
| Deyovaisio Zeefuik | DEF | Out indefinitely | Groin Strain | Groin Strain | Oct 25 |
| Agustin Rogel | DEF | Out indefinitely | Knee Injury | Knee Injury | Feb 20 |
| Andrej Kramaric | F | Out indefinitely | Virus | Virus | Feb 21 |
| Mergim Berisha | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Jan 20 |
| Vladimir Coufal | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| Adam Hlozek | F | Out indefinitely | Hlozek, Adam: missing - injured | Hlozek is injured | Aug 23 |
| Grischa Promel | MID | Out indefinitely | None | Promel is injured | Apr 25 |
| Anthony Caci | DEF | Out | Gluteal Strain | Gluteal Strain | Feb 29 |
| Niklas Tauer | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Feb 6 |
| Maxim Dal | DEF | Out indefinitely | Dal, Maxim: missing - injured | Dal is injured | Aug 23 |
| Benjamin Henrichs | DEF | Out indefinitely | None | Henrichs is injured | Jan 11 |
| Timo Werner | F | Out indefinitely | None | Werner is injured | May 15 |
| Forzan Assan Ouedraogo | MID | Out indefinitely | None | Ouedraogo is injured | Nov 29 |
| M. Terrazzino | A | Out | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Oct 4 |
| C. Okoroji | DEF | Out indefinitely | Thigh Muscle Rupture | Thigh Muscle Rupture | Jun 17 |
| M. Ritter | A | Out | Back Injury | Back Injury | Nov 30 |
| S. Mamba | A | Out | Suspended | Suspended | Jun 13 |
| Paul Seguin | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | May 9 |
| Timo Baumgartl | DEF | Out indefinitely | Testicular Cancer | Testicular Cancer | Sep 8 |
| Thomas Ouwejan | DEF | Out indefinitely | Groin Strain | Groin Strain | Mar 13 |
| Ibrahima Cisse | DEF | Out indefinitely | Knock | Knock | Feb 6 |
| Leo Greiml | DEF | Out indefinitely | Knock | Knock | Jan 23 |
| Oussama Haddadi | DEF | Out | Suspended | Suspended | Dec 20 |
| Oliver Burke | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jun 7 |
| Robert Skov | F | Out | Robert Skov is expected to return Mid November 2025 from Calf injury. | Skov is out with calf | Oct 30 |
| Danilho Doekhi | DEF | Out indefinitely | None | Doekhi is injured | Oct 27 |
| Alex Kral | MID | Out indefinitely | Back Injury | Back Injury | Jan 30 |
| Andras Schafer | MID | Out indefinitely | Foot Injury | Foot Injury | Apr 11 |
| Livan Burcu | MID | Doubtful | Livan Burcu is Doubtful with Lack of fitness. | Burcu is doubtful with conditioning | Oct 22 |
| Andrik Markgraf | DEF | Out | Andrik Markgraf is expected to return Mid November 2025 from Broken leg. | Markgraf is out with leg | Oct 30 |
| Mitchell Weiser | DEF | Out indefinitely | Weiser, Mitchell: missing - injured | Weiser is injured | Aug 23 |
| Maximilian Wober | DEF | Out indefinitely | Thigh Muscle Rupture | Thigh Muscle Rupture | Apr 11 |
| Felix Agu | DEF | Out | Felix Agu is expected to return Mid January 2026 from Ankle injury. | Agu is out with ankle | Oct 23 |
| Olivier Deman | MID | Out | Olivier Deman is expected to return Mid December 2025 from Broken ankle. | Deman is out with ankle | Oct 24 |
| Salim Musah | F | Out | Salim Musah is expected to return Mid November 2025 from Thigh injury. | Musah is out with thigh | Oct 30 |
| Christian Eriksen | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Feb 25 |
| Lovro Majer | MID | Out | Nose Injury | Nose Injury | Aug 24 |
| Kevin Paredes | MID | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Jan 23 |
| Kilian Fischer | DEF | Out | Kilian Fischer is expected to return Mid November 2025 from Foot injury. | Fischer is out with foot | Oct 23 |
| Moritz Jenz | DEF | Out indefinitely | Knock | Knock | Apr 11 |
| Dzenan Pejcinovic | F | Out indefinitely | None | Pejcinovic is injured | May 17 |
| Denis Vavro | DEF | Out | Denis Vavro is expected to return Early December 2025 from Groin injury. | Vavro is out with groin | Sep 19 |
FC Ingolstadt 04
FC Nürnberg
Fortuna Düsseldorf
Greuther Furth
Hannover 96
Hertha BSC
SC Paderborn 07
Schalke 04
Tunisia
