| Yeray Alvarez | DEF | Suspended | Yeray Álvarez is serving a suspension for Doping. | Alvarez is suspended with doping | Sep 11 |
| Inigo Lekue | DEF | Out | Iñigo Lekue is expected to return Early November 2025 from Muscle injury. | Lekue is out with muscle | Oct 26 |
| Inaki Williams | F | Out | Iñaki Williams is expected to return Early November 2025 from Muscle injury. | Williams is out with muscle | Oct 23 |
| Alex Berenguer | F | Out | Suspended | Suspended | Feb 27 |
| Yuri Berchiche | DEF | Out | Suspended | Suspended | Feb 11 |
| Andoni Gorosabel | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Feb 20 |
| Benat Prados | MID | Out for season | Beñat Prados is Out for season with Cruciate ligament injury. | Prados is out for season with knee | Sep 16 |
| Unai Egiluz | DEF | Out indefinitely | None | Egiluz is injured | Aug 15 |
| Thomas Lemar | MID | Out indefinitely | Knee Injury | Knee Injury | Feb 27 |
| Rodrigo De Paul | MID | Out indefinitely | Hamstring | Hamstring | Mar 14 |
| Jose Maria Gimenez | DEF | Out indefinitely | Knock | Knock | Jan 30 |
| Jan Oblak | GK | Out indefinitely | None | Oblak is injured | May 24 |
| Koke | MID | Out indefinitely | Hamstring | Hamstring | Nov 9 |
| Alexander Sorloth | F | Out indefinitely | Hamstring | Hamstring | Oct 18 |
| Nahuel Molina | DEF | Out | Suspended | Suspended | Sep 3 |
| Alex Baena | MID | Out indefinitely | Baena, Alex: missing - injured | Baena is injured | Aug 22 |
| Pablo Barrios | MID | Out indefinitely | None | Barrios Rivas is injured | Dec 2 |
| Robin Le Normand | DEF | Doubtful | Robin Le Normand is Doubtful with Back injury. | Le Normand is doubtful with back | Sep 15 |
| Pablo Perez | DEF | Out | Pablo Pérez is expected to return Late September 2025 from Thigh injury. | Perez is out with thigh | Sep 9 |
| Ilias Kostis | DEF | Out for season | Ilias Kostis is Out for season with Cruciate ligament injury. | Kostis is out for season with knee | Oct 13 |
| Robert Lewandowski | F | Out indefinitely | Hamstring | Hamstring | Mar 14 |
| Marc-Andre Ter Stegen | GK | Out indefinitely | Illness | Illness | May 10 |
| Dani Olmo | MID | Out | Dani Olmo is expected to return Early November 2025 from Calf injury. | Olmo is out with calf | Oct 11 |
| Raphinha | F | Out | Suspended | Suspended | Apr 1 |
| Pedri | MID | Out indefinitely | Hamstring | Hamstring | Apr 11 |
| Joan Garcia | GK | Doubtful | Joan García is Doubtful with Meniscus injury. | Garcia is doubtful with knee | Oct 27 |
| Javier Ontiveros | F | Out | Shoulder Injury | Shoulder Injury | Apr 27 |
| Lucas Boye | F | Out | Suspended | Suspended | Apr 1 |
| Asier Villalibre | F | Out indefinitely | Hamstring | Hamstring | May 2 |
| Denis Suarez | MID | Doubtful | Suarez, Denis: doubtful - other | Suarez is doubtful | Aug 25 |
| Mariano Diaz | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 13 |
| Moussa Diarra | DEF | Suspended | None | Diarra is suspended | May 23 |
| Ander Guevara | MID | Out indefinitely | Hamstring | Hamstring | Feb 14 |
| Nikola Maras | DEF | Doubtful | Nikola Maras is Doubtful with Ligament injury. | Maras is doubtful with ligament | Oct 24 |
| Raul Fernandez | GK | Doubtful | None | Fernandez is doubtful | May 18 |
| Facundo Garces | DEF | Out indefinitely | Facundo Garces is serving a suspension for Police investigation. | Garces is injured with unknown | Oct 7 |
| Bambo Diaby Diaby | DEF | Out | Bambo Diaby is expected to return Mid November 2025 from Unknown. | Diaby is out with unknown | Oct 24 |
| Javi Puado | MID | Out | Javi Puado is expected to return Early November 2025 from Knee injury. | Puado is out with knee | Oct 8 |
| Luca Koleosho | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Sep 5 |
| Jose Gragera | MID | Out | José Gragera is expected to return Mid October 2025 from Thigh injury. | Gragera is out with thigh | Sep 29 |
| Abdel Abqar | DEF | Doubtful | Abdel Abqar is Doubtful with Physical discomfort. | Abqar is doubtful with soreness | Oct 18 |
| Jorge Benito | GK | Out | Jordi Martín is expected to return Mid January 2026 from Cruciate ligament injury. | Benito is out with knee | Aug 26 |
| Allan Nyom | DEF | Suspended | Allan Nyom is serving a suspension for Red card. | Nyom is suspended with red card | Oct 19 |
| Mubarak Wakaso | MID | Out | Suspended | Suspended | Jan 18 |
| Daley Blind | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jun 15 |
| David Lopez | DEF | Doubtful | David Lopez is Doubtful with Thigh injury. | Lopez is doubtful with thigh | Oct 19 |
| Axel Witsel | MID | Out indefinitely | Knock | Knock | May 2 |
| Alex Moreno | F | Out indefinitely | Knock | Knock | Apr 4 |
| Azzedine Ounahi | MID | Doubtful | None | Ounahi is doubtful | May 14 |
| Alejandro Frances | DEF | Suspended | Alejandro Frances is serving a suspension for Red card. | Frances is suspended with red card | Oct 4 |
| Mathew Ryan | GK | Out | Knee Injury | Knee Injury | Aug 28 |
| Diego Pampin | F | Out | Diego Pampin is expected to return Early November 2025 from Physical discomfort. | Pampin is out with soreness | Oct 25 |
| Omar Mascarell | MID | Out | Suspended | Suspended | Feb 15 |
| Sergi Darder | MID | Out | Virus | Virus | Jan 17 |
| Takuma Asano | F | Out indefinitely | Knee Injury | Knee Injury | Nov 11 |
| Pablo Maffeo | DEF | Out | Suspended | Suspended | Nov 9 |
| Martin Valjent | DEF | Out indefinitely | Back Injury | Back Injury | Apr 11 |
| Vedat Muriqi | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Nov 28 |
| Dani Rodriguez | MID | Out indefinitely | Dani Rodriguez is Unknown with Personal reasons. | Rodriguez is injured with personal | Oct 20 |
| M. Peybernes | DEF | Out | Suspended | Suspended | Feb 19 |
| Juanfran | DEF | Out indefinitely | Hamstring | Hamstring | Nov 26 |
| Weligton Róbson Pena de Oliveira | DEF | Out indefinitely | Knee Injury | Knee Injury | Jun 9 |
| Juan Carlos Pérez López | DEF | Out | Suspended | Suspended | Jan 5 |
| Miguel Torres Gómez | DEF | Out | Hamstring | Hamstring | May 24 |
| Sérgio Paulo Barbosa Valente | MID | Out indefinitely | Toe Injury | Toe Injury | May 22 |
| Keko | MID | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | May 5 |
| Zdravko Kuzmanović | MID | Out indefinitely | Pubalgia | Pubalgia | Jun 12 |
| Jozabed | MID | Out | Suspended | Suspended | Jan 22 |
| Pablo Hervías | MID | Out indefinitely | Cartilage Knee Injury | Cartilage Knee Injury | Apr 6 |
| Adrián | A | Out indefinitely | Knock | Knock | Jun 15 |
| Brandon Thomas Llamas | A | Out | Suspended | Suspended | Jan 3 |
| C. Gönen | GK | Out indefinitely | Shoulder Injury | Shoulder Injury | Jun 12 |
| L. Agbenyenu | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Jul 17 |
| Joaquín Muñoz | A | Out | Suspended | Suspended | Mar 27 |
| P. Chavarría | A | Out indefinitely | Knock | Knock | Sep 29 |
| E. Burgos | DEF | Out | Suspended | Suspended | Feb 20 |
| M. Benkhemassa | MID | Out | Suspended | Suspended | Jan 26 |
| Caye Quintana | A | Out | Suspended | Suspended | Dec 5 |
| Jonás Ramalho | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Nov 22 |
| Genaro Rodríguez | MID | Out | Suspended | Suspended | Jan 15 |
| Ante Budimir | F | Out indefinitely | Pubalgia | Pubalgia | Oct 25 |
| Lucas Torro | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | May 23 |
| Sergio Herrera | GK | Out indefinitely | Knee Injury | Knee Injury | Nov 9 |
| Aimar Oroz | F | Out | Aimar Oroz is expected to return Early November 2025 from Foot injury. | Oroz is out with foot | Oct 19 |
| M. Koné | A | Out | Suspended | Suspended | Jan 12 |
| Raúl Carnero | DEF | Out | Suspended | Suspended | Mar 19 |
| Fernando Navarro i Corbacho | DEF | Out | Suspended | Suspended | Apr 1 |
| Rober | DEF | Out indefinitely | Knock | Knock | Nov 29 |
| Ivan Balliu | DEF | Out | Suspended | Suspended | Oct 17 |
| Oscar Trejo | F | Out | Calf Muscle Strain | Calf Muscle Strain | Jun 5 |
| Luiz Felipe | DEF | Out indefinitely | Hamstring | Hamstring | Apr 4 |
| Thibaut Courtois | GK | Out indefinitely | Hamstring | Hamstring | Feb 20 |
| David Alaba | DEF | Out indefinitely | Hamstring | Hamstring | Apr 11 |
| Antonio Rudiger | DEF | Out indefinitely | Hamstring | Hamstring | Dec 7 |
| Dani Ceballos | MID | Out indefinitely | Hamstring | Hamstring | Oct 31 |
| Dani Carvajal | DEF | Out indefinitely | Hamstring | Hamstring | Jan 30 |
| Ferland Mendy | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 11 |
| Rodrygo | F | Out indefinitely | None | Rodrygo is injured | May 23 |
| Aurelien Tchouameni | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Feb 2 |
| Jude Bellingham | MID | Out indefinitely | Knock | Knock | Dec 6 |
| Eduardo Camavinga | MID | Out | Eduardo Camavinga is expected to return Mid September 2025 from Shin injury. | Camavinga is out with shin | Aug 29 |
| Eric Bailly | DEF | Out | Suspended | Suspended | Feb 13 |
| Josip Brekalo | F | Out indefinitely | Illness | Illness | Jan 30 |
| Leander Dendoncker | MID | Out | Knock | Knock | Mar 12 |
| Ovie Ejaria | F | Doubtful | Ovie Ejaria is Doubtful with Hamstring Injury. | Ejaria is doubtful with hamstring | Oct 28 |
| Santi Cazorla | MID | Out | Santiago Cazorla is expected to return Early November 2025 from Muscle injury. | Cazorla is out with muscle | Oct 20 |
| Umar Sadiq | F | Out indefinitely | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Apr 11 |
| Carlos Fernandez | F | Out indefinitely | None | Fernandez is injured | Jan 19 |
| Carlos Soler | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Apr 9 |
| Goncalo Guedes | MID | Out | Knock | Knock | Apr 21 |
| Yangel Herrera | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 4 |
| Takefusa Kubo | MID | Out | Takefusa Kubo is expected to return Early November 2025 from Muscle injury. | Kubo is out with muscle | Oct 27 |
| Jon Karrikaburu | F | Out | Jon Karrikaburu is expected to return Mid November 2025 from Leg injury. | Karrikaburu is out with leg | Oct 28 |
| Orri Oskarsson | F | Out indefinitely | None | Oskarsson is injured | May 3 |
| Y. Muto | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 26 |
| Matheus Pereira | MID | Out | Suspended | Suspended | Oct 30 |
| Etxeita | DEF | Out | Suspended | Suspended | Apr 23 |
| Anaitz Arbilla Zabala | DEF | Out | Suspended | Suspended | Mar 13 |
| Iván Ramis Barrios | DEF | Out indefinitely | Knee Injury | Knee Injury | Jul 24 |
| Francisco Manuel Rico Castro | MID | Out indefinitely | Knee Injury | Knee Injury | Jun 30 |
| Imanol Sarriegui Isasa | MID | Out | Hand Injury | Hand Injury | Mar 7 |
| Roberto Antonio Correa Silva | DEF | Out | Suspended | Suspended | Jan 8 |
| Paulo Oliveira | DEF | Out indefinitely | Hamstring | Hamstring | Dec 29 |
| G. Blanco | A | Out | Suspended | Suspended | Jan 10 |
| Javi Muñoz | MID | Out | Suspended | Suspended | Apr 1 |
| Enrique González Casín | A | Out indefinitely | Knock | Knock | Dec 23 |
| Peru Nolaskoain | DEF | Out | Suspended | Suspended | Jan 15 |
| Juan Berrocal | DEF | Out | Suspended | Suspended | Mar 7 |
| S. Okazaki | A | Out indefinitely | Hamstring | Hamstring | Nov 9 |
| Mikel Rico | MID | Out indefinitely | Virus | Virus | Nov 9 |
| Pablo Ínsua Blanco | DEF | Out | Suspended | Suspended | Apr 2 |
| Timor | MID | Out indefinitely | Knock | Knock | Dec 20 |
| Luisinho | DEF | Out indefinitely | Knee Injury | Knee Injury | May 22 |
| Juan Pablo Añor Acosta | MID | Out indefinitely | Hamstring | Hamstring | May 1 |
| Juan Pérez | GK | Out indefinitely | Arm/Elbow injury | Arm/Elbow injury | Dec 20 |
| Cristian Salvador | MID | Out | Suspended | Suspended | Jan 9 |
| Óscar Sielva | MID | Out | Suspended | Suspended | Feb 26 |
| Gerard Valentín | DEF | Out indefinitely | Hamstring | Hamstring | Dec 26 |
| Eugeni Valderrama | MID | Out indefinitely | Hamstring | Hamstring | May 22 |
| K. Nwakali | MID | Out indefinitely | Knock | Knock | Oct 18 |
| Pedro López Muñoz | DEF | Out indefinitely | Hamstring | Hamstring | Nov 9 |
| Juan Carlos | | Out | Virus | Virus | Jan 31 |
| Pablo Martínez | MID | Out | Suspended | Suspended | Oct 31 |
| Alexis Sanchez | F | Out indefinitely | Knee Injury | Knee Injury | Apr 21 |
| Cesar Azpilicueta | DEF | Out | Head Injury | Head Injury | Apr 11 |
| Djibril Sow | MID | Out indefinitely | Knock | Knock | Jun 14 |
| Oerjan Haaskjold Nyland | GK | Out indefinitely | Back Injury | Back Injury | Feb 14 |
| Rafa Mir | F | Out indefinitely | Knock | Knock | Apr 4 |
| Joan Jordan | MID | Out indefinitely | None | Jordan is injured | Aug 15 |
| Lucien Agoume | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Jan 19 |
| Chidera Ejuke | F | Out indefinitely | Knee Injury | Knee Injury | Apr 11 |
| Batista Mendy | MID | Out | Suspended | Suspended | Feb 19 |
| Alejandro Bergantiños García | MID | Out | Suspended | Suspended | Mar 11 |
| Javi Fuego | MID | Out | Suspended | Suspended | Mar 26 |
| Álvaro Vázquez | A | Out | Shoulder Injury | Shoulder Injury | Sep 12 |
| Jony | MID | Out | Suspended | Suspended | Feb 12 |
| Pichu Cuéllar | GK | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Mar 1 |
| J. Babin | DEF | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Feb 25 |
| Fernando Amorebieta Mardaras | DEF | Out indefinitely | Knock | Knock | Apr 3 |
| Pedro Díaz Fanjul | MID | Out | Suspended | Suspended | May 10 |
| Juan Rodríguez Martínez | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | May 1 |
| Sergio Álvarez Díaz | MID | Out | Suspended | Suspended | Feb 12 |
| José Ángel Valdés Díaz | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Aug 24 |
| Jordi Calavera Espinach | DEF | Out indefinitely | Knock | Knock | Apr 22 |
| Pablo Pérez | MID | Out | Suspended | Suspended | May 7 |
| Molinero | DEF | Out | Suspended | Suspended | Jul 6 |
| Marc Valiente | DEF | Out | Suspended | Suspended | Nov 30 |
| J. Otero | A | Out | Suspended | Suspended | Dec 14 |
| Víctor Campuzano | A | Out indefinitely | Back Injury | Back Injury | Mar 1 |
| Vasyl Kravets | DEF | Out | Suspended | Suspended | Jan 23 |
| Fran Villalba | MID | Out | Suspended | Suspended | Apr 2 |
| José Marsà | DEF | Out | Suspended | Suspended | Apr 8 |
| Luis Javier Suarez | F | Out | Suspended | Suspended | Apr 22 |
| Houboulang Mendes | DEF | Out | Knee Injury | Knee Injury | Jan 24 |
| Marko Marezi | F | Out indefinitely | Pubalgia | Pubalgia | Oct 29 |
| Mouctar Diakhaby | DEF | Out | Mouctar Diakhaby is expected to return Late November 2025 from Hamstring Injury. | Diakhaby is out with hamstring | Oct 18 |
| Dimitri Foulquier | DEF | Out indefinitely | Hamstring | Hamstring | Jan 20 |
| Jose Gaya | DEF | Doubtful | Jose Gaya is Doubtful with Ankle injury. | Gaya is doubtful with ankle | Oct 28 |
| Thierry Correia | DEF | Out indefinitely | Hamstring | Hamstring | Feb 27 |
| Alberto Mari | F | Out indefinitely | None | Mari is injured | Aug 14 |
| Largie Ramazani | F | Out | Largie Ramazani is expected to return Early November 2025 from Muscle injury. | Ramazani is out with muscle | Oct 19 |
| Pepelu | MID | Doubtful | Pepelu is Doubtful with Muscle injury. | Pepelu is doubtful with muscle | Oct 28 |
| Filip Ugrinic | MID | Doubtful | Filip Ugrinic is Doubtful with Knee injury. | Ugrinic is doubtful with knee | Oct 11 |
| Thomas Partey | MID | Out | Back Injury | Back Injury | Feb 25 |
| Ayoze Perez | F | Out indefinitely | Illness | Illness | Dec 27 |
| Juan Foyth | DEF | Out indefinitely | Knee Injury | Knee Injury | Nov 7 |
| Manor Solomon | MID | Out | Knee Injury | Knee Injury | Jan 5 |
| Pau Cabanes | F | Out | Pau Cabanes is expected to return Early April 2026 from Cruciate ligament injury. | Cabanes is out with knee | Aug 27 |
Ghana
Málaga CF
RC Deportivo La Coruna
SD Eibar
SD Huesca
Sporting Gijón
