Giants vs. Padres Odds & Betting Predictions - August 21, 2025

Giants at Padres

1:40 am • MLB Network

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San Francisco Giants

@

San Diego Padres

pitcher		team	era	w-l
L.Roupp			0.00	0-0

MatchupOpenSpreadTotalMoneyline
Giants 61-64	N/A	N/A	N/A
Padres 69-56	N/A	N/A	N/A

location pin

Thursday 1:40 a.m.

August 21, 2025

PETCO ParkSan Diego

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73°Fahrenheit

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0%Rain

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4Wind

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MLB Public Betting

Padres are 1-4 in their last 5 games.
Padres are 3-2 in their last 5 games against the spread
Padres are 36-30 in their road games against the spread
The totals have gone OVER in 2 of Padres' last 5 games
The totals have gone OVER in 25 of Padres' 59 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Padres	68-57	32-27	36-30	30-37	37-20
Giants	53-72	24-39	29-33	25-51	27-20

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Padres	51-70-4	25-33-1	26-37-3	34-31-2	17-38-2
Giants	56-65-4	24-38-1	32-27-3	26-49-1	28-16-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Padres	69-56	38-21	31-35	40-27	28-29
Giants	61-64	30-33	31-31	38-38	22-25

date	opponent	score	spread	over/under	moneyline
Aug 19th	SF	L 3-4	-1.5 L	U 7.5	SF -149
Aug 17th	@LAD	L 4-5	+1.5 W	O 8.5	LAD +120
Aug 17th	@LAD	L 0-6	+1.5 L	U 7.5	LAD +103
Aug 16th	@LAD	L 2-3	+1.5 W	U 9	LAD +120
Aug 13th	@SF	W 11-1	-1.5 W	O 8	SD -144

Tom Murphy
C
Murphy is out with back
Out

Joe Musgrove
SP
Musgrove is out for season with elbow
Out for Season
Michael King
SP
Michael King (shoulder) has been scratched Saturday. Sean Reynolds will start for the Padres.
Out

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MatchupOverUnder
Giants 61-64	N/A	N/A
Padres 69-56	N/A	N/A