Guardians vs. Tigers Odds & Betting Predictions - May 21, 2026

Guardians at Tigers

5:10 pm • CLEG

Cleveland Guardians

@

Detroit Tigers

pitcher		team	era	w-l
C.Mize			2.43	2-2
J.Cantillo			3.40	3-1

MatchupOpenSpreadTotalMoneyline
Guardians 27-22	N/A	N/A	N/A
Tigers 20-28	N/A	N/A	N/A

location pin

Thursday 5:10 p.m.

May 21, 2026

Comerica ParkDetroit

thermometer image

59°Fahrenheit

rain image

0%Rain

wind image

10Wind

No props found

MLB Public Betting

Tigers are 1-4 in their last 5 games.
Tigers are 2-3 in their last 5 games against the spread
Tigers are 9-17 in their road games against the spread
The totals have gone OVER in 2 of Tigers' last 5 games
The totals have gone OVER in 9 of Tigers' 22 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Tigers	23-25	14-8	9-17	14-14	9-9
Guardians	28-21	16-9	12-12	16-12	12-9

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Tigers	22-24-2	9-11-2	13-13	12-14-2	9-9
Guardians	26-23	12-13	14-10	15-13	11-10

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Tigers	20-28	13-9	7-19	14-14	6-12
Guardians	27-22	15-10	12-12	16-12	11-10

date	opponent	score	spread	over/under	moneyline
May 19th	CLE	L 3-4	+1.5 W	U 8	CLE +135
May 18th	CLE	L 2-8	-1.5 L	O 8	CLE -156
May 17th	TOR	L 1-4	+1.5 L	U 7.5	TOR -102
May 16th	TOR	L 1-2	+1.5 W	U 8	TOR -115
May 15th	TOR	W 3-2	+1.5 W	U 8	DET +105

Reese Olson
SP
Olson is out with shoulder
Out
Jackson Jobe
SP
Jobe is out with elbow
Out
Trey Sweeney
SS
Sweeney is out with shoulder
Out
Sawyer Gipson-Long
SP
Gipson-Long is out with oblique
Out
Beau Brieske
RP
Brieske is out with groin
Out
Troy Melton
SP
Melton is out with elbow
Out

See more MLB Injuries

PITCHER		W-L	ERA	WHIP	K/9
LJ.Cantillo, P		3-1	3.40	1.351	8.05

PITCHER		W-L	ERA	WHIP	K/9
RC.Mize, P		2-2	2.43	1.054	9.49

Could not load odds

See more MLB Odds

MatchupOverUnder
Guardians 27-22	N/A	N/A
Tigers 20-28	N/A	N/A