Guardians vs. Tigers Odds & Betting Predictions - May 21, 2026
Guardians at Tigers
5:10 pm • CLEGStarting Pitchers
| pitcher | team | era | w-l | |
|---|---|---|---|---|
![]() | 2.43 | 2-2 | ||
![]() | 3.40 | 3-1 |
Guardians at Tigers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Guardians 27-22 | N/A | N/A | N/A | |
Tigers 20-28 | N/A | N/A | N/A | |

Comerica ParkDetroit
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Prop Odds Comparison
Line Movement Tracker
Guardians vs. Tigers Public Betting Percentages
Betting Trends
- Tigers are 1-4 in their last 5 games.
- Tigers are 2-3 in their last 5 games against the spread
- Tigers are 9-17 in their road games against the spread
- The totals have gone OVER in 2 of Tigers' last 5 games
- The totals have gone OVER in 9 of Tigers' 22 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Guardians vs. Tigers Injury Updates

Guardians Injuries

Tigers Injuries
- Reese OlsonSP
Olson is out with shoulder
Out
- Jackson JobeSP
Jobe is out with elbow
Out
- Trey SweeneySS
Sweeney is out with shoulder
Out
- Sawyer Gipson-LongSP
Gipson-Long is out with oblique
Out
- Beau BrieskeRP
Brieske is out with groin
Out
- Troy MeltonSP
Melton is out with elbow
Out
Guardians vs. Tigers Starting Lineups
Guardians Starting Lineup| PITCHER | W-L | ERA | WHIP | K/9 | |
|---|---|---|---|---|---|
![]() | 3-1 | 3.40 | 1.351 | 8.05 |
Tigers Starting Lineup| PITCHER | W-L | ERA | WHIP | K/9 | |
|---|---|---|---|---|---|
![]() | 2-2 | 2.43 | 1.054 | 9.49 |
Guardians vs. Tigers Odds Comparison
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Guardians at Tigers Team Totals
MatchupOverUnder | ||
|---|---|---|
Guardians 27-22 | N/A | N/A |
Tigers 20-28 | N/A | N/A |


