Padres vs. Mariners Odds & Betting Predictions - May 16, 2026

Padres at Mariners

1:40 am • SEAM

San Diego Padres

34-31

2 - 0

Seattle Mariners

35-32

pitcher		team	era	w-l
E.Hancock			2.74	5-2
R.Vasquez			3.64	5-4

MatchupOpenSpreadTotalMoneyline
Padres 34-31	+1.5	+1.5-196	o7-120	+114
Mariners 35-32	u7.5	-1.5+164	u7+100	-135

Saturday 1:40 a.m.

May 16, 2026

T-Mobile ParkSeattle

Over 2.5 (Live)+160

SD +110

1.1u

SD +123 (F5)

0.65u

#EV 1.29%

Under 7.5-122

SD +115

1.15u

Join Discord for earlier access: https://discord.gg/HjKxYKdSUy San Diego is 25-18 against a 22-23 Seattle team, and the plus price is too generous for that gap. Randy Vasquez has a 3.05 ERA and has allowed only 4 home runs in 8 starts. Seattle is missing Cal Raleigh on the 10-Day-IL, which trims a key bat from the catcher spot.

R.Vasquez o1.5 BB-130

1.3u

E.Hancock o5.5 Ks+144

1.17u

#EV

E.Hancock o4.5 Ks-155

Under 7.5-112

0.5u

Bet to 7 (-105)

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MLB Public Betting

Mariners are 2-3 in their last 5 games.
Mariners are 2-3 in their last 5 games against the spread
Mariners are 14-18 in their road games against the spread
The totals have gone OVER in 3 of Mariners' last 5 games
The totals have gone OVER in 17 of Mariners' 35 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Mariners	26-41	12-23	14-18	24-38	2-3
Padres	36-29	20-16	16-13	16-16	20-13

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Mariners	30-35-2	17-17-1	13-18-1	29-31-2	1-4
Padres	27-37-1	14-21-1	13-16	12-19-1	15-18

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Mariners	35-32	19-16	16-16	33-29	2-3
Padres	34-31	18-18	16-13	17-15	17-16

date	opponent	score	spread	over/under	moneyline
May 14th	@HOU	W 8-3	-1.5 W	O 9	SEA -115
May 14th	@HOU	L 3-4	-1.5 L	U 9	HOU -138
May 13th	@HOU	W 10-2	-1.5 W	O 9	SEA -202
May 12th	@HOU	W 3-1	-1.5 W	U 8.5	SEA -155
May 10th	@CWS	L 1-2	-1.5 L	U 8	CWS -138

Miles Mastrobuoni
IF
Mastrobuoni is out with calf
Out

Joe Musgrove
P
Musgrove is out with elbow
Out
Will Wagner
IF
Wagner is out with oblique
Out

See more MLB Injuries

PITCHER	PC	IP	K
RR.Vasquez, P	79	6	3
LA.Morejon, P	16	1	1
RJ.Adam, P	14	0.2	1
RM.Miller, P	34	1.1	4

HITTERS	H-AB	R	RBI
1J.Merrill, CF	0-4	0	0
2F.Tatis, RF	0-4	0	0
3M.Machado, 3B	0-4	0	0
4G.Sheets, 1B	2-3	1	0
4B.Johnson, PR	0-0	0	0
4T.France, 1B	0-0	0	0
5X.Bogaerts, SS	2-4	0	0
6M.Andujar, DH	2-4	1	1
7R.Laureano, LF	2-4	0	0
8S.Song, 2B	1-4	0	1
9F.Fermin, C	0-3	0	0

PITCHER	PC	IP	K	ER
RE.Hancock, P	91	6	6	1
RC.Criswell, P	13	1	0	1
LJ.Ferrer, P	11	1	1	0
RA.Hoppe, P	13	1	0	0

HITTERS	H-AB	R	HR	RBI
1B.Donovan, 3B	1-5	0	0	0
2J.Rodriguez, CF	0-3	0	0	0
3J.Naylor, 1B	1-4	0	0	0
4R.Arozarena, LF	2-4	0	0	0
5L.Raley, RF	0-1	0	0	0
5C.Joe, PH	0-1	0	0	0
5C.Joe, RF	0-1	0	0	0
6J.Crawford, SS	0-3	0	0	0
7D.Canzone, DH	1-2	0	0	0
7R.Refsnyder, PH	0-2	0	0	0
7R.Refsnyder, DH	0-2	0	0	0
8C.Young, 2B	2-4	0	0	0
9J.Pereda, C	0-3	0	0	0
9M.Garver, PH	0-1	0	0	0