Duke vs. Siena Odds
| Duke Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-29 -110 | 136 -110o / -110u | -10000 |
| Siena Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+29 -110 | 136 -110o / -110u | +3300 |
The 2026 NCAA Tournament field has been announced and Duke will take on Siena in Round 1 of the East region. Here's everything you need to know about Duke vs. Siena odds, spread and more.
Duke opened as a 29-point favorite over Siena in the first round of the NCAA Tournament. The total is set at over/under 136 points scored by both teams combined.
Find out how No. 1-seeded Duke and No. 16-seeded Siena match up ahead of their opening round matchup.
Duke vs. Siena Analysis
Duke is the top overall seed and the top-rated team in KenPom entering the tournament.
However, the Blue Devils could be short-handed, as point guard Caleb Foster is out, and big man Patrick Ngongba is questionable.
Still, the Blue Devils won the ACC Tournament without that pair.
Cam Boozer is the best player in the country, averaging 22 points, 10.5 rebounds, and 4.2 assists per game. His ability to handle the ball, dish to shooters, and score for himself will be something Siena hasn’t seen all year.
Duke will have a significant length advantage. It’s the second-tallest team nationally (per KenPom’s average height metric), while Siena ranks 278th in that metric.
Siena played just one high-major opponent all season, losing to Indiana — which didn’t make the tournament — by 21.
This spread is hefty, but Siena will have no chance to score on the long-armed Blue Devils. This feels like a 30-plus-point Duke win.
— Sean Paul
For more coverage of the 2026 NCAA Tournament and Selection Sunday, make sure to check out our experts' live reactions to the bracket reveal and the Selection Sunday live show, where you can get their instant analysis on every matchup as well as some early insights to help you make your bets.
