The Mississippi State Bulldogs take on the Iowa State Cyclones in Sioux Falls, S.D. Tip-off is set for 8:00 p.m. EST on ESPNU.
Iowa State is favored by 5 points on the spread with a moneyline of -230. The total is set at 151.5 points.
Here’s my Mississippi State vs. Iowa State prediction and college basketball picks for November 10, 2025.
Mississippi St vs Iowa State Prediction
My Pick: Mississippi State Team Total Under
My Mississippi State vs Iowa State best bet is on the Under for the Bulldogs. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
Mississippi State vs. Iowa State Odds
| Mississippi State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+5 -110 | 151.5 -110o / -110u | +190 |
| Iowa State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-5 -110 | 151.5 -110o / -110u | -230 |
- Mississippi State vs Iowa State spread: Mississippi State +5 (-110), Mississippi State -5 (-110)
- Mississippi State vs Iowa State over/under: 151.5 (-110o / -110u)
- Mississippi State vs Iowa State moneyline: Mississippi St +190, Iowa State -230
Mississippi State vs Iowa State College Basketball Betting Preview
Mississippi State Basketball
Chris Jans begins year four at the helm for the Bulldogs.
Jans has posted three consecutive 21-win seasons for Mississippi State, which included three straight NCAA Tournament appearances.
Before 2023, the Bulldogs had made the big dance just once (2019).
Mississippi State begins the season unranked but believes that they have enough talent to make another postseason push.
The Bulldogs opened their season with an 86-62 win over North Alabama. Senior Joshua Hubbard led the team with 27 points in the win. Hubbard is one of the best guards in the SEC.
UAB transfer Ja’Borri McGhee is expected to be a key piece of this team. McGhee dropped 14 points in the season opener.
Iowa State Basketball
The Cyclones enter the season with high expectations once again.
Iowa State has been one of the best teams in the Big 12 over the past few seasons.
TJ Otzelberger has led this program to four consecutive postseason appearances.
Otzelberger has his Cyclones off to a fast 2-0 start this season.
Iowa State defeated Fairleigh Dickinson and Grambling to open the season.
Junior Milan Momcilovic has led the Cyclones with 20.0 points per game early in the season.
Iowa State returns key players from last year, including Joshua Jefferson, Tamin Lipsey, and Nate Heise, while freshman Killyan Toure is expected to play a key role this year.
Mississippi State vs. Iowa State Betting Analysis
The pace of this contest will bode well for this play.
Iowa State can be a top-tier defensive team this season.
I love the way that the Cyclones match up with this Bulldogs team.
Otzelberger will have a strong game plan to limit Joshua Hubbard's production and force other players on the floor to beat them.
I do not think the Bulldogs have enough shooting to put up big offensive numbers against strong defensive teams.
The Bulldogs' shaky outside shooting, paired with the Cyclones' strong rim protection, makes this a strong play.
My Pick: Mississippi State Team Total Under
