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The Missouri Tigers take on the Saint Louis Billikens in St. Louis, MO. Tip-off is set for 7 p.m. ET on ESPNU.
Missouri is favored by -2.5 points on the spread, with a moneyline of -144. The total is set at 162.5 points.
Here’s my Missouri vs. Saint Louis prediction and college basketball picks for November 6, 2026.
Missouri vs Saint Louis Prediction
Pick: Missouri -2.5 | Missouri ML -144 | Crowe Over Points Prop
My Missouri vs Saint Louis best bet is on Mizzou to not only win outright but cover the spread at the same time, fueled in part by a big game from Jason Crowe Jr. Be sure to find the best lines by using our live NCAAB odds page and download the Action Network app for the latest picks and analysis.
Missouri vs Saint Louis Odds
| Missouri Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-2.5 -110 | 162.5 -115o / -105u | -144 |
| Saint Louis Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+2.5 -110 | 162.5 -115o / -105u | +118 |
- Missouri vs Saint Louis spread: Missouri -2.5 (-110), Saint Louis +2.5 (-110)
- Missouri vs Saint Louis over/under: 162.5 (-115o / -105u)
- Missouri vs Saint Louis moneyline: Missouri -144, Saint Louis +118
Missouri vs Saint Louis College Basketball Preview
Missouri Basketball
Missouri head coach Dennis Gates had a remarkable offseason heading into his fifth campaign at the helm, with the Tigers’ roster undergoing a complete overhaul.
Gates led the Tigers to the NCAA Tournament in three of his first four seasons as head coach in Columbia, with the sole absence coming in 2023.
In one of the more surprising recruiting commitments of the 2026 freshman class, Gates landed the eighth-ranked player in the country, 6-foot-3 guard Jason Crowe Jr.
Crowe is an exceptional athlete and elite natural-scoring lefty combo guard who boasts elite explosiveness and a beautiful 3-point stroke with deep range.
The Tigers’ 18-year-old superstar just put up an impressive 23 points in a 51-point beatdown over Cleveland State.
Crowe leads an elite backcourt that also features fellow true freshman Guard Toni Bryant.
Gates also retained all-SEC forward Mark Mitchell, who picked up right where he left off last season, posting an exceptional 11-point, five-rebound, 10-assist stat line on Tuesday night in just 24 minutes.
Missouri’s frontcourt boasts sizable experience with 6-foot-10 senior forward Trent Pierce returning for his final collegiate season. Pierce adds some much-needed veteran leadership to a rotation oozing with elite young talent.
The Tigers had one of the most successful transfer portal classes in all of college basketball, featuring Bryson Tiller, Jaylen Carey, Jamier Jones and Kennard Davis Jr., amongst others.
This is easily the deepest and most talented lineup Missouri has had in the Gates era, boasting elite length, size and physicality in its frontcourt alongside Crowe.
The Tigers are absolutely loaded from top to bottom and are a fringe top-25 team.
Saint Louis Basketball
The Billikens enter the season with high hopes after a school-record 29 victories.
In a transfer-portal era defined by complete team overhauls, Saint Louis boasts some unique roster continuity, retaining five players who averaged over nine points per game.
Head coach Josh Schertz has built an elite high-octane offensive system that will largely remain intact this season, and Saint Louis’ lineup chemistry will undoubtedly play a major role in the team’s success, particularly early on in the season.
While Robbie Avila’s eligibility remains in limbo, Saint Louis will have to do without him on Friday, which I am sure the Bills be able to manage given their significant roster retention.
Schertz returned the likes of Trey Green, Kellen Thames, Quentin Jones, Amari McCottry and Ishan Sharma.
Missouri vs. Saint Louis Pick, Betting Analysis
I am expecting fireworks on Friday night as these two prepare to square off in their first meeting since 2001.
In addition to the enticing "Missouri clash" narrative, we will see an old-school versus new-age duel that pits roster continuity against the modern portal era.
While Saint Louis thrived all of last season largely due to its exceptional 3-point shooting prowess — setting a program record with 379 triples — the Billikens, unfortunately, will run into a Missouri squad boasting freakish length and athleticism that could give Schertz’s bunch problems implementing its high-octane offensive system.
Though Saint Louis has some impressive length on its roster too, with Thames standing at 6-foot-6 with a spectacular 3-point stroke, this Tigers’ lineup has some incredible genetics on its side and could very well put an experienced Billiken squad out of its comfort zone.
The Billikens are undoubtedly gifted offensively, but I expect this to be a very difficult challenge for them on the defensive end of the floor versus a Tiger squad I feel has legitimate Final Four upside with Crowe leading the charge.
While I typically would favor backing the more experienced team this early-on in the season, I'm rolling with Missouri both on the -194 moneyline and to cover its -4.5 spread in what I expect to be a “put the country on notice” type of performance.
As a third betting angle, I feel confident backing Crowe to soar over his points total in what I expect to be another huge performance from the Tigers’ youngster.
Pick: Missouri -2.5 (Play to -4.5) | Missouri ML -144 (Play to -195) | Crowe Over Points Prop
