The Furman Paladins take on the Clemson Tigers in Clemson, South Carolina. Kickoff is set for 4:30 p.m. EST on The CW.
Clemson is favored by 41.5 points on the spread, while the total sits at 54.5.
Here’s my Furman vs. Clemson prediction and college football picks for Saturday, November 22, 2025.
Furman vs Clemson Prediction
- Furman vs. Clemson Pick: Clemson -41.5 (-110, bet365)
My Clemson vs. Furman best bet is on the Tigers to cover. Find the best line available on our live NCAAF odds page.
Furman vs Clemson Odds
| Furman Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+41.5 -110 | 54.5 -110o / -110u | |
| Clemson Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-41.5 -110 | 54.5 -110o / -110u | |
Furman vs Clemson Preview
I’m going to lay the points with Clemson.
Dabo Swinney has never missed a Bowl Game as the Clemson head coach. He needs six wins, and he’s one game away.
Over the past few games, he’s been playing the classic “us against the world” trope in his post-game pressers.
However, the defense has been playing great lately. The Tigers have recently held Florida State to 10 and Louisville to 19.
If Furman can’t score, it’ll have a tough time covering here because its defense is garbage.
The Paladins’ top three opponents in the SoCon this season put up monster numbers — Western Carolina won 52-7, Mercer won 52-28, and Chattanooga won 45-28.
Furman ranks 96th among FCS teams in total defense and 93rd in pass defense.
Swinney typically dominates these low-level FCS teams in this spot. Here are his past six November buy games:
- 51-14 win over The Citadel
- 44-7 win over UConn
- 59-14 win over Wofford
- 61-3 win over The Citadel
- 28-0 win over Georgia State
- 52-6 win over The Citadel
Swinney wants to see his team play four full quarters of good football and springboard the Tigers into a good Bowl Game.
Pick: Clemson -41.5 (-110, bet365)
