The Houston Cougars take on the Arizona State Sun Devils in Tempe, Arizona. Kickoff is set for 8:00 p.m. EDT on ESPN2.
Arizona State is favored by 7 points on the spread with a moneyline of -280. The total is set at 45.5 points.
Here’s my Houston vs. Arizona State prediction and college football picks for Saturday, October 25, 2025.
Houston vs Arizona State Prediction, Picks
- Houston vs. Arizona State Pick: Houston +7.5
My Arizona State vs. Houston best bet is on the Cougars to cover. Find the best line available on our live NCAAF odds page.
Houston vs Arizona State Odds
| Houston Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+7 -110 | 45.5 -110o / -110u | +230 |
| Arizona St Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-7 -110 | 45.5 -110o / -110u | -280 |
- Houston vs Arizona State point spread: Arizona State -7 (-110), Houston +7 (-110)
- Houston vs Arizona State over/under: 45.5 (-110o / -110u)
- Houston vs Arizona State moneyline: Houston +230, Arizona State -280
Houston Cougars vs Arizona State Sun Devils College Football Week 9 Picks
I bet Houston +7.5 earlier in the week in anticipation of a poor injury report for Arizona State, which also finds itself in a tough spot after an emotional comeback win over Texas Tech. It turned out the Sun Devils will indeed be shorthanded.
Most noteworthy is the loss of Jordyn Tyson, who might be the best wide receiver in the country. That could completely neuter the offense and make Houston's game plan much more straightforward.
Additionally, the defense may have to make do without its top pass rusher, starting linebacker, and a couple of starting safeties.
The ASU special teams remain an absolute disaster. While head coach Willie Fritz is a covering machine, so is Sam Leavitt (15-2 ATS!).
I don't fully trust this Houston offense on the road, so I may come back for some if the line drops.
Pick: Houston +7.5
How To Watch Houston vs Arizona State Live
- Time: 8 p.m. ET
- TV Channel: ESPN2
- Location: Mountain America Stadium, Tempe, AZ
Moneyline
No play.
Against The Spread
I'm taking the points with Houston.
Over/Under
No play.
