The Kansas Jayhawks take on the Iowa State Cyclones in Ames, Iowa. Kickoff is set for 12:00 p.m. EST on Fox Sports 1.
Iowa State is favored by 4 points on the spread with a moneyline of -180. The total is set at 55.5 points.
Here’s my Kansas vs. Iowa State prediction and college football picks for Saturday, November 22, 2025.
Kansas vs Iowa State Prediction
- Kansas vs. Iowa State Pick: Iowa State 1H -3 or Better
My Iowa State vs. Kansas best bet is on Iowa State to cover the first-half spread. Find the best line available on our live NCAAF odds page.
Kansas vs Iowa State Odds
| Kansas Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+4 -110 | 55.5 -110o / -110u | +150 |
| Iowa State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-4 -110 | 55.5 -110o / -110u | -180 |
- Kansas vs Iowa State point spread: Iowa State -4 (-110), Kansas +4 (-110)
- Kansas vs Iowa State over/under: 55.5 (-110o / -110u)
- Kansas vs Iowa State moneyline: Kansas +150, Iowa State -180
Kansas vs Iowa State Preview
Kansas Jayhawks Betting Preview: Defensive Woes to Continue
The Jayhawks enter this matchup having lost three of their past four games while getting outscored 129-92.
While Jalon Daniels has been solid at quarterback, they have been unable to overcome their defensive struggles.
Kansas ranks 116th nationally in yards per rush allowed and 56th in yards per pass allowed. The Jayhawks have been ravaged on the ground, as their defensive line has been unable to generate a push.
Their inability to slow down the run has compounded drives and put the defense in a tough spot. Kansas ranks 100th in red zone scoring rate allowed and 90th in takeaways per game.
In this matchup, we should see Iowa State exploit the Jayhawks' defense as the Cyclones have a talented running back duo that has combined to average 5.2 yards per carry this season.
Iowa State Cyclones Betting Preview: Cyclones Hold Edge in Trenches
The Cyclones snapped a losing streak last week with a victory over TCU.
They now have an opportunity to build on that momentum at home, where their defense will need to step up again.
They were able to contain a high-volume passing offense last week, and this week, they'll need their defensive line to step up.
The issues for Kansas offensively are up front, as they rank 92nd in sack rate allowed and 72nd in yards per rush.
The Cylcones' defense ranks 126th in sack rate and 96th in yards per rush allowed. On paper, that does not bode well for them, but the Jayhawks are a good matchup for a Cylcones defense that is healthier and improving.
Look for Iowa State to load the box and force Daniels to beat them with his arm, while testing Kansas' offensive line to hold up.
Kansas vs Iowa State Pick, Betting Analysis
There has been little movement in the market for this matchup, but a strong lean is emerging.
The Cyclones have momentum and are poised to start hot at home.
Look for their defense to be aggressive early, filling gaps to slow down the Jayhawks' ground game while their offense marches down the field.
Pick: Iowa State 1H -3 or Better
