The Kentucky Wildcats take on the South Carolina Gamecocks in Columbia, SC. Kickoff is set for 7:45 p.m. ET on SEC Network.
South Carolina is favored by -6.5 points on the spread with a moneyline of -250. The total is set at 46 points.
Here’s my Kentucky vs. South Carolina predictions and college football picks for Saturday, September 27, 2025.
Kentucky vs S. Carolina Prediction
- Kentucky vs. South Carolina Pick: Kentucky +6.5
My South Carolina vs. Kentucky best bet is on the Wildcats spread. Find the best line available on our live NCAAF odds page.
Kentucky vs South Carolina Odds
| Kentucky Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+6.5 -110 | 46 -110o / -110u | +205 |
| South Carolina Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-6.5 -110 | 46 -110o / -110u | -250 |
- Kentucky vs South Carolina point spread: South Carolina -6.5
- Kentucky vs South Carolina over/under: 46 points
- Kentucky vs South Carolina moneyline: Kentucky +205, South Carolina -250
Kentucky vs South Carolina Pick, Betting Analysis
Kentucky and South Carolina both search for their first win in SEC play as they face off at Williams-Brice Stadium on Saturday evening.
The Wildcats are coming off a tune-up game against Eastern Michigan while the Gamecocks have dropped two straight (Vanderbilt and Missouri).
South Carolina was ranked as high as No. 10 overall in the AP Poll, but the 31-7 beatdown suffered at home against Vanderbilt knocked it out of the rankings altogether.
According to the books, the Gamecocks are expected to bounce back this week against the Wildcats. But our very own Evan Abrams has a system that aligns with the Wildcats covering the 6.5-point spread. This system has a 9.4% return on investment (ROI) since its inception.
"Early Road Redemption" is a college football system that identifies value on visiting teams in the opening stretch of the season after they've underperformed against the spread in their previous outing.
The market often punishes these teams too heavily for a single early loss, creating inflated lines in the next matchup. By narrowing the spread range between modest underdogs and double digit spots, the system captures situations where the road team is competitive but overlooked.
These games are played in manageable weather conditions and typically fall within lower scoring totals, which reduce volatility and keep contests closer than expected.
When teams in their first eight games seek redemption on the road after a poor showing against the spread, they frequently outperform expectations, making this a profitable angle.
Pick: Kentucky +6.5
