Cardinals vs. Titans Week 1 Opening Odds, Line: Arizona Opens as Underdog vs. New-Look Titans

Cardinals vs. Titans Odds

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The Arizona Cardinals kick off the 2021 NFL regular season on the road against the new-look Tennessee Titans at Nissan Stadium on Sept. 12.  Arizona will be looking to make significant strides in Year three with dynamic quarterback Kyler Murray.

Arizona showed some improvements in the 2020 season, finishing with a .500 record behind the play of their Pro Bowl QB.

In Week 1 of the 2021 season, the Cardinals will be taking on a Titans team that just added two-time All-Pro wide receiver, Julio Jones.

In a matchup between two physical teams that can eat up yardage on the ground, the opening odds have Tennessee as a slight favorite over Arizona.

With the Titans making some of the splashier moves of the NFL offseason, it comes as no surprise that the public is hammering the Titans' side of the action. At the time of this writing, 66% of the spread tickets have landed on the Titans.

Arizona bettors who feel strongly about the Cardinals coming out on top in Week 1 will definitely want to take a look at the moneyline for Cardinals vs. Titans on DraftKings, which has Arizona as a +155 underdog at the time of this writing.

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Arizona Cardinals Betting Trends, Futures

The Arizona Cardinals finished the 2020 NFL season 8-8, ending the year with two tough NFC West losses.

Arizona was 7-9 Against The Spread (ATS) last season, and they possessed a slightly better ATS record on the road at 4-4.

The Cardinals made some exciting offseason additions themselves, adding defensive end J.J. Watt to a D-line that already features the dominant Chandler Jones.

And on the offensive side of the ball, wideout AJ Green and running back James Conner add serious big-time firepower to the Arizona offense, even with their extensive injuries histories.

The Action Network's Sean Koerner projects the spread for Cardinals vs. Titans at Arizona +3.5, making the Cardinals worth a look as the public continues to hammer the favorite.

The Action Network's Stuckey has released his power ratings that have the 49ers winning the division but have the Cardinals even with the Rams and Seahawks behind San Francisco.

Stuckey ultimately stayed away from the NFC West division odds and instead bet on the 49ers to make the postseason. If Arizona bettors believe in this year's squad having enough talent to win the NFC West, the Cardinals sit as a juicy +650 underdog to win the division at DraftKings.