The Los Angeles Chargers (2-1) and San Francisco 49ers (1-1) will face off in NFL Preseason Week 3. Kickoff is set for 8:30 p.m. EDT from Levi's Stadium in Santa Clara, Calif. The game will broadcast live on NFL+.
The Chargers are favored by -1.5 with the over/under set at 35.5 total points. Los Angeles is a -130 favorite to win outright, while San Francisco is +110 to pull off the upset.
Let's get into my 49ers vs Chargers predictions and NFL picks for Saturday, August 23.
Chargers vs 49ers Odds
| Chargers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -115 | 35.5 -115o / -105u | -130 |
| 49ers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -105 | 35.5 -115o / -105u | +110 |
My Chargers vs 49ers best bet is on the Chargers first-half moneyline, with the best price currently available at DraftKings. But as always, make sure to find the best odds by checking our live NFL odds page.
Chargers vs. 49ers NFL Preseason Week 3 Preview, Prediction
The 49ers will host the Chargers on Saturday Night as both teams wrap up the preseason.
Los Angeles will attempt to finish with a win and improve their record to 3-1.
I love this spot for the Chargers tonight in the first half.
Jim Harbaugh's team has the edge at the quarterback position tonight. Former 49er Trey Lance will be under center in the first half.
Lance has impressed in the preseason and will continue his success against his former team tonight.
Pick: Los Angeles Chargers 1H ML (-142, DraftKings)
Spread
I'm not interested in the spread for this game.
Moneyline
As mentioned, I prefer to go with the first-half moneyline, backing the Chargers early.
Over/Under
I have no play on the total.
49ers vs Chargers Betting Trends
NFL Weather
