Cardinals vs. Astros Odds & Betting Predictions - March 22, 2026

Cardinals at Astros

4:05 pm • SCHN

St. Louis Cardinals

@

Houston Astros

pitcher		team	era	w-l
C.Javier			1.59	0-0
M.McGreevy			2.70	3-0

MatchupOpenSpreadTotalMoneyline
Cardinals 15-9	N/A	N/A	N/A
Astros 10-13	N/A	N/A	N/A

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Sunday 4:05 p.m.

March 22, 2026

The Ballpark of the Palm BeachesWest Palm Beach

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77°Fahrenheit

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MLB Public Betting

Astros are 3-2 in their last 5 games.
Astros are 3-2 in their last 5 games against the spread
Astros are 45-36 in their road games against the spread
The totals have gone OVER in 1 of Astros' last 5 games
The totals have gone OVER in 36 of Astros' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Astros	82-80	37-44	45-36	43-60	39-18
Cardinals	80-82	41-40	39-42	25-42	54-40

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Astros	72-83-7	36-43-2	36-40-5	45-56-2	25-27-5
Cardinals	81-74-7	39-39-3	42-35-4	33-29-5	47-45-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Astros	87-75	46-35	41-40	56-47	31-26
Cardinals	78-84	44-37	34-47	33-34	44-50

date	opponent	score	spread	over/under	moneyline
Mar 20th	MIA	L 4-7	-	-	-
Mar 19th	NYM	L 2-6	+1.5 L	O 7	NYM +105
Mar 18th	@STL	L 1-4	-1.5 L	U 7	STL -142
Mar 17th	@PIT	W 10-2	+1.5 W	O 7.5	HOU +124
Mar 15th	MIA	W 1-0	-1.5 L	U 8.5	HOU -140

Hayden Wesneski
RP
Wesneski is out with elbow
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Masyn Winn
SS
Masyn Winn (knee) has been scratched Friday.
Out

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MatchupOverUnder
Cardinals 15-9	N/A	N/A
Astros 10-13	N/A	N/A