Cardinals vs. Giants Odds & Betting Predictions - September 25, 2025

Cardinals at Giants

1:45 am • FDSMW

St. Louis Cardinals

78-81

3 - 4

San Francisco Giants

78-81

pitcher		team	era	w-l
J.Brubaker			3.38	0-0
S.Gray			4.28	14-8

MatchupOpenSpreadTotalMoneyline
Cardinals 78-81	+1.5	-1.5+146	o7.5+155	-115
Giants 78-81	u7.5	+1.5-180	u7.5-206	-105

Thursday 1:45 a.m.

September 25, 2025

Oracle ParkSan Francisco

STL -1.5+146

📚Player Profit 🔑 Cardinals -1.5 +146 (Player Profit) 3u Sonny Gray making his last start of the season after back to back good starts. Both teams are out of it and the Giants going with a bullpen game, and free falling. Cardinals trying to end the season strong, love this spot. Code: sirlocks for 10% off every deposit at https://www.playerprofit.com/

STL -108

0.54u

A.Burleson o1.5 Hits + Runs + RBIs-120

STL -110

Over 7.5-117

3 MLB Player Props for Wednesday, 9/24
Alex Hinton•
Sep 24, 2025 UTC

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No props found

MLB Public Betting

Giants are 2-3 in their last 5 games.
Giants are 2-3 in their last 5 games against the spread
Giants are 41-40 in their road games against the spread
The totals have gone OVER in 3 of Giants' last 5 games
The totals have gone OVER in 34 of Giants' 78 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Giants	74-85	33-45	41-40	33-56	40-28
Cardinals	80-79	41-40	39-39	25-42	54-37

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Giants	74-78-7	34-43-1	40-35-6	35-53-1	37-25-6
Cardinals	79-73-7	39-39-3	40-34-4	33-29-5	45-44-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Giants	78-81	39-39	39-42	46-43	31-37
Cardinals	78-81	44-37	34-44	33-34	44-47

date	opponent	score	spread	over/under	moneyline
Sep 24th	STL	L 8-9	-1.5 L	O 7.5	STL -200
Sep 23rd	STL	L 5-6	-1.5 L	O 8	STL -148
Sep 21st	@LAD	W 3-1	+1.5 W	U 9	SF +178
Sep 21st	@LAD	L 5-7	+1.5 L	O 9	LAD +200
Sep 20th	@LAD	L 3-6	+1.5 L	U 9	LAD +160

Jose Fermin
2B
Jose Fermin scratched Tuesday.
Out
Masyn Winn
SS
Masyn Winn (knee) has been scratched Friday.
Out

Thomas Murphy
C
Murphy is out with back
Out
Jonathan Brubaker
RP
Brubaker is out with ribs
Out

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PITCHER	PC	IP	K	ER
RS.Gray, P	99	6	7	2
RK.Leahy, P	13	1	2	0
RR.O'Brien, P	16	1	0	1

HITTERS	H-AB	R	RBI
1B.Donovan, 2B	1-4	1	1
2I.Herrera, DH	2-3	1	1
3A.Burleson, 1B	1-4	0	0
4N.Arenado, 3B	0-3	0	1
5L.Nootbaar, LF	0-2	0	0
6T.Saggese, SS	1-4	0	0
7P.Pages, C	1-4	0	0
7N.Church, PR	0-0	0	0
8J.Walker, RF	0-4	0	0
9V.Scott, CF	1-3	1	0
9J.Fermin, PH	0-1	0	0

PITCHER	PC	IP	K	ER
RJ.Brubaker, P	68	4	4	2
RC.Seymour, P	42	3	4	0
LM.Gage, P	12	0.1	1	1
RJ.Butto, P	13	0.2	1	0
RT.Beck, P	11	1	0	0

HITTERS	H-AB	R	HR	RBI
1H.Ramos, LF	1-5	0	0	0
1P.Bailey, C	0-0	0	0	0
2R.Devers, DH	1-4	1	1	1
3W.Adames, SS	1-5	0	0	0
4B.Eldridge, 1B	2-4	0	0	0
5C.Schmitt, 3B	3-4	1	0	0
6J.Lee, CF	1-4	0	0	0
7C.Koss, 2B	1-3	2	0	0
8D.Gilbert, RF	0-4	0	0	0
9A.Knizner, C	1-2	0	0	2
9G.McCray, PR	0-0	0	0	0
9G.McCray, LF	0-0	0	0	0