Orioles vs. Red Sox Odds & Betting Predictions - July 22, 2026

Orioles at Red Sox

5:35 pm • NESN
1 - 4

Orioles at Red Sox Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Orioles
49-52
+1.5
+1.5-152
o9.5-105
+144
Red Sox
51-48
u9.5
-1.5+118
u9.5-115
-175
location pinWednesday 5:35 p.m.
July 22, 2026
Fenway ParkBoston
Orioles vs. Red Sox Expert Picks
Austin Pendergrass
Austin Pendergrass
Last 30d: 41-21-3 (+9.5u)
BOS -144
0.5u
Matthew Lopes
Matthew Lopes
Last 30d: 41-167-3 (-19.6u)
W.Contreras To Hit 1+ Home Runs Yes+300
1u
W.Abreu To Hit 1+ Home Runs Yes+335
1u
Frank Ammirante
Frank Ammirante
Last 30d: 331-373-6 (-39.0u)
J.Bennett u1.5 BB-125
1.25u
Under 9.5-110
1.1u
Zense
Zense
Last 30d: 25-23-4 (-1.0u)
BOS -140
1u
Sandy Plashkes
Sandy Plashkes
Last 30d: 75-86-0 (+11.6u)
BAL +142
1u
Wags Wins
Wags Wins
Last 30d: 200-179-4 (+7.8u)
BOS -1.5+145
1u
Adam Kaufman
Adam Kaufman
Last 30d: 122-107-3 (+9.6u)
BOS -140
1.4u
OldSchool0909
Last 30d: 31-33-0 (+5.1u)
BAL +120
1u

Orioles vs. Red Sox Previews & Analysis

  • Derek Carty's 4 MLB Player Props for Wednesday article feature image

    Derek Carty's 4 MLB Player Props for Wednesday

    Action Network Staff
    Jul 22, 2026 UTC
  • Carty's Prop Pick for Orioles vs Red Sox Game 1 article feature image

    Carty's Prop Pick for Orioles vs Red Sox Game 1

    Action Network Staff
    Jul 22, 2026 UTC
  • Opening Pitch: Zerillo's MLB Projections for Wednesday via BARTOLO article feature image

    Opening Pitch: Zerillo's MLB Projections for Wednesday via BARTOLO

    Sean Zerillo
    Jul 21, 2026 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Orioles vs. Red Sox Public Betting Percentages

Away Logo

Orioles

Public

16%

Bets%

84%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Red Sox
47-5221-2826-2428-3518-17
Orioles
50-5127-2623-2523-2826-23

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Red Sox
45-50-420-26-325-24-130-30-315-19-1
Orioles
53-45-327-24-226-21-124-25-229-19-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Red Sox
51-4822-2729-2132-3118-17
Orioles
49-5228-2521-2726-2522-27

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jul 20thBALW 6-5-1.5 LO 8.5BOS -166
Jul 19thTBW 6-1-1.5 WU 8.5BOS -125
Jul 18thTBW 7-6+1.5 WO 9.5BOS -119
Jul 17thTBW 5-3-1.5 WU 9BOS -131
Jul 17thTBW 10-0+1.5 WO 8.5BOS -118

Orioles vs. Red Sox Injury Updates

Orioles Injuries

  • Heston Kjerstad
    LF

    Kjerstad is out with hamstring

    Out

  • Jordan Westburg
    3B

    Westburg is out with elbow

    Out

Red Sox Injuries

  • Tanner Houck
    SP

    Houck is out with arm

    Out

  • Triston Casas
    1B

    Casas is out with knee

    Out

  • Kutter Crawford
    SP

    Crawford is out with wrist

    Out

Orioles vs. Red Sox Box Score
Orioles Player Stats
Projected
PITCHERPCIPKER
Dean Kremer logoRD.Kremer, P502.144
HITTERSH-ABRHRRBI
Taylor Ward logo1T.Ward, LF0-2000
Pete Alonso logo2P.Alonso, 1B1-2100
Gunnar Henderson logo3G.Henderson, SS1-2000
Tyler O'Neill logo4T.O'Neill, RF1-2001
Coby Mayo logo5C.Mayo, DH0-2000
Leody Taveras logo6L.Taveras, CF0-1000
Christian Encarnacion-Strand logo7C.Encarnacion-Strand, 3B1-1000
Jackson Holliday logo8J.Holliday, 2B1-1000
Sam Huff logo9S.Huff, C0-1000
Red Sox Player Stats
Projected
PITCHERPCIPKER
Jake Bennett logoLJ.Bennett, P46331
HITTERSH-ABRHRRBI
Masataka Yoshida logo1M.Yoshida, DH1-1100
Ceddanne Rafaela logo2C.Rafaela, CF1-2100
Wilyer Abreu logo3W.Abreu, RF0-2000
Willson Contreras logo4W.Contreras, 1B1-2100
Caleb Durbin logo5C.Durbin, 3B1-1102
Romy Gonzalez logo6R.Gonzalez, 2B0-1000
Jarren Duran logo7J.Duran, LF1-1002
Connor Wong logo8C.Wong, C0-1000
Tsung-Che Cheng logo9T.Cheng, SS0-1000

Orioles vs. Red Sox Odds Comparison

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Orioles at Red Sox Team Totals

MatchupOverUnder
Orioles
49-52
N/A
N/A
Red Sox
51-48
N/A
N/A