Padres vs. Giants Odds & Betting Predictions - May 6, 2026

Padres at Giants

1:45 am • NBCS-BA

San Diego Padres

40-37

10 - 5

San Francisco Giants

31-46

pitcher		team	era	w-l
L.Webb			3.35	4-5
W.Buehler			3.96	4-3

MatchupOpenSpreadTotalMoneyline
Padres 40-37	+1.5	+1.5-172	o7.5-108	+123
Giants 31-46	u7.5	-1.5+145	u7.5-113	-149

Wednesday 1:45 a.m.

May 06, 2026

Oracle ParkSan Francisco

SF +3.5 (Live)+150

0.75u

Under 14.5 (Live)-110

1.1u

Over 7.5 (Live)-109

Under 11.5 (Live)-114

1.14u

Under 11 (Live)-132

1.32u

SF -1.5+165

0.33u

#EV 2.18%

N.Castellanos o0.5 Hits-165

0.73u

#EV 5.82%

R.Devers o1.5 Hits + Runs + RBIs-115

SD +110

1.1u

Under 7.5-115

0.5u

@Zerillo ⭐️⭐️ https://myaction.app/JSRRLRwFT2b

W.Buehler o3.5 Ks-110

0.5u

Under 7.5-115

0.58u

Bet to -125 or 7 (-102)

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MLB Public Betting

Giants are 2-3 in their last 5 games.
Giants are 2-3 in their last 5 games against the spread
Giants are 19-24 in their road games against the spread
The totals have gone OVER in 2 of Giants' last 5 games
The totals have gone OVER in 16 of Giants' 34 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Giants	33-44	14-20	19-24	10-17	23-26
Padres	42-35	21-18	21-17	17-17	25-18

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Giants	36-36-5	16-16-2	20-20-3	16-9-2	19-27-3
Padres	33-43-1	16-22-1	17-21	13-20-1	20-23

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Giants	31-46	14-20	17-26	12-15	19-30
Padres	40-37	20-19	20-18	19-15	21-22

date	opponent	score	spread	over/under	moneyline
May 5th	SD	W 3-2	+1.5 W	U 8	SF +112
May 3rd	@TB	L 1-2	+1.5 W	U 8	TB +104
May 2nd	@TB	L 1-5	-1.5 L	U 7.5	TB -116
May 1st	@TB	L 0-3	+1.5 L	U 7.5	TB +117
Apr 30th	@PHI	L 5-6	+1.5 W	O 8.5	PHI +118

Hayden Birdsong
SP
Birdsong is out with arm
Out

Joe Musgrove
SP
Musgrove is out with elbow
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RW.Buehler, P	82	5.1	5	4
RJ.Estrada, P	21	1.2	2	1
RJ.Adam, P	9	1	0	0
RR.Marinaccio, P	9	1	1	0

HITTERS	H-AB	R	HR	RBI
1J.Merrill, CF	3-5	2	0	2
2M.Machado, 3B	0-5	0	0	0
3M.Andujar, DH	3-5	1	0	1
4G.Sheets, 1B	2-5	1	0	0
5F.Tatis, RF	1-5	1	0	0
6X.Bogaerts, SS	2-4	1	1	2
7N.Castellanos, LF	1-3	1	0	2
7B.Johnson, LF	0-1	0	0	0
8L.Campusano, C	0-2	1	0	0
9S.Song, 2B	2-4	2	0	2

PITCHER	PC	IP	K	ER
RL.Webb, P	62	4	4	6
RJ.Brubaker, P	38	1	1	1
LR.Borucki, P	20	1	0	1
RG.Santos, P	28	2	0	2
RJ.Peguero, P	8	1	0	0

HITTERS	H-AB	R	HR	RBI
1J.Lee, RF	1-4	1	0	1
2C.Schmitt, 2B	1-4	1	1	2
3R.Devers, 1B	1-4	0	0	0
4H.Ramos, LF	0-4	0	0	0
5B.Eldridge, DH	1-4	0	0	0
6M.Chapman, 3B	0-4	0	0	0
7W.Adames, SS	1-4	1	0	0
8D.Gilbert, CF	1-3	1	0	0
8C.Koss, PH	0-1	0	0	0
9J.Rodriguez, C	2-3	1	1	2