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Diamondbacks vs Rockies Prediction, Pick, MLB Odds for Wednesday, September 23

Diamondbacks vs Rockies Prediction, Pick, MLB Odds for Wednesday, September 23 article feature image
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Christopher Hanewinckel-Imagn Images. Pictured: Rockies catcher Hunter Goodman

The Colorado Rockies host the Arizona Diamondbacks on September 23, 2026. First pitch from Coors Field is scheduled for 8:40 p.m. ET. The game will be broadcast on COLR.

The Diamondbacks are favored by -160 on the moneyline and by -1.5 on the run line. The Rockies are +135 on the moneyline and +1.5 on the run line. The total is set at 11 runs.

Find our MLB picks and Diamondbacks vs Rockies prediction below, as well as probable pitchers, weather report, and more.


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Diamondbacks vs Rockies Prediction

  • Diamondbacks vs Rockies Pick: Rockies F5 ML (+115)

Our Diamondbacks vs Rockies best bet is Colorado to lead after five innings. Make sure to find the best odds by checking our live MLB odds page, and download the Action Network app for more picks and analysis.


Diamondbacks vs Rockies Odds

Diamondbacks Logo
Wednesday, Sep 23
8:40 p.m. ET
COLR
Rockies Logo
Diamondbacks Odds
SpreadTotalMoneyline
-1.5
-105
11
-120o / 100u
-160
Rockies Odds
SpreadTotalMoneyline
+1.5
-115
11
-120o / 100u
+135
Odds via BetMGM. Get up-to-the-minute MLB odds here.
BetMGM Logo
  • Diamondbacks vs Rockies moneyline: Diamondbacks -160, Rockies +135
  • Diamondbacks vs Rockies over/under: 11 (-120o / +100u)
  • Diamondbacks vs Rockies spread: Diamondbacks -1.5 (-105), Rockies +1.5 (-115)

Diamondbacks vs Rockies Probable Pitchers

Merrill Kelly (RHP, ARI)StatMason Adams (RHP, COL)
9-14W-L0-1
-0.2fWAR (FanGraphs)-0.1
5.00 / 6.45ERA / xERA5.09 / 5.83
5.40 / 4.92FIP / xFIP6.19 / 4.50
6.1K-BB%10.9
40.1GB%36.9
.285BABIP.339
89Stuff+94
101Location+98

Diamondbacks vs Rockies MLB Betting Preview

Sean Zerillo's projections show solid value on the Rockies moneyline for the first five innings against the Diamondbacks, with a 4.6% edge.

If you want to dive deeper into this game, check out BARTOLO, Zerillo's new PRO baseball tool that gives you access to all the input data he uses to project games every day.


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Diamondbacks vs Rockies Pick, Betting Analysis

Even though Arizona is the clear favorite here, the key to backing Colorado early is the huge difference in the reliever corps between the two teams.

Zerillo has the Diamondbacks at the top of his MLB bullpen rankings, while the Rockies are dead last, as you can see here.

That contrast doesn't show up when you compare starters, as Merrill Kelly ranks 178th while Mason Adams takes the 155th spot.

With Colorado doing much better at home (32-47) than on the road (25-53), backing them to lead after five innings, before the bullpens come into action, is a smart play.

Pick: Rockies F5 ML (+115, BetMGM)

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