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Reds vs Braves Prediction, Pick, MLB Odds for Wednesday, September 23

Reds vs Braves Prediction, Pick, MLB Odds for Wednesday, September 23 article feature image
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Sep 20, 2026; Houston, Texas, USA; Atlanta Braves designated hitter Ronald Acuna Jr. (13) celebrates after the final out against the Houston Astros during the ninth inning at Daikin Park. Mandatory Credit: Erik Williams-Imagn Images

The Atlanta Braves host the Cincinnati Reds on September 23, 2026. First pitch from Truist Park is scheduled for 7:15 p.m. EDT. The game will be broadcast on BravesVsn.

The Braves are favored by -255 on the moneyline and by -1.5 on the run line. The Reds are +210 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.

Find my MLB picks and Reds vs Braves prediction below, as well as probable pitchers, weather report, and more.


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Reds vs Braves Prediction

  • Reds vs Braves Picks: Braves -1.5, Braves F5 -0.5 & Ronald Acuna Over 2.5 HRR

My Reds vs Braves best bets are for the Braves to cover the run line and F5 line, as well as Ronald Acuna to exceed 2.5 HRR. Make sure to find the best odds by checking our live MLB odds page and download the Action Network app for more picks and analysis!


Reds vs Braves Odds

Reds Logo
Wednesday, Sep 23
7:15 p.m. ET
BravesVsn
Braves Logo
Reds Odds
SpreadTotalMoneyline
+1.5
-111
7.5
-100o / -122u
+210
Braves Odds
SpreadTotalMoneyline
-1.5
-108
7.5
-100o / -122u
-255
Odds via FanDuel. Get up-to-the-minute MLB odds here.
FanDuel Logo
  • Reds vs Braves moneyline: Reds +210, Braves -255
  • Reds vs Braves over/under: 7.5 (-100o / -122u)
  • Reds vs Braves spread: Braves -1.5 (-108), Reds +1.5 (-111)

Reds vs Braves Probable Pitchers

Andrew Abbott (LHP, CIN)StatChris Sale (LHP, ATL)
6-11W-L14-9
1.4fWAR (FanGraphs)5.7
4.70 / 5.01ERA / xERA2.18 / 3.05
4.90 / 4.96FIP / xFIP2.28 / 2.87
7.1%K-BB%25.4%
39.0%GB%45.1%
.283BABIP.303
94Stuff+118
99Location+109

Reds vs Braves MLB Betting Preview

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Reds vs Braves Pick, Betting Analysis

Lefty ace Chris Sale will take the mound for the Braves on Wednesday evening while the Reds will trot out Andrew Abbott in a southpaw duel.

Sale has been exceptional in his 16th season, ranking amongst baseball’s top starters in nearly every pitching metric.

Atlanta’s veteran southpaw has a 14-9 overall record this season, and is posting a 2.18 ERA (third), 0.99 WHIP (fifth), and 190 Ks (13th).

The same can't be said of Abbott, who enters Wednesday night’s contest posting a 4.70 ERA with a 1.47 WHIP in 159 innings.

With Atlanta being home and trotting out a superior pitcher, I like taking the Braves in the F5 and full-game runline.

I'm also targeting Braves’ superstar Ronald Acuña Jr. to have a massive night at the plate.

Acuña is in the midst of an incredible heater and is arguably the hottest hitter over the last three weeks, hitting .340 with five homers and 13 RBIs over his last 15 games.

Abbott has struggled mightily with his command this season, frequently falling behind in the count, thus forcing him to throw strikes over the plate, which has left him quite susceptible to heavy damage.

Acuña's elite exit velocities and raw power at the plate should result in him holding a definitive edge over Abbott, who has consistently struggled finding his spots against right-handed hitters in 2026.

Picks:

  • Braves -1.5 (-111)
  • Braves F5 -0.5
  • Ronald Acuna Over 2.5 HRR (-140)

Reds vs Braves Weather


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Author Profile
About the Author

Ryan graduated from Providence College in 2016 with Bachelor Degrees in Business Economics & Mathematics. It was at Providence where Ryan really first found his passion for sports betting. For a lifelong sports fan with a knack for statistical analysis, he was instantly drawn to the fundamentals of the industry, specifically how sports betting markets functioned and fluctuated. In what primarily started as a recreational hobby, Ryan began studying the ins-and-outs of sports betting markets on a daily basis. He took to Twitter (now X), where he amassed a following for writing a sports betting blog that provided statistical analysis behind his wagers. In spite of seeking employment opportunities elsewhere post graduation, Ryan continued to follow his passion for the statistical analysis of sports betting wagers, eventually deciding to pursue a career in the sports betting industry.

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